PIPA5102837
LATS2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102837-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA5102837 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
LATS2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
LATS2
Gene Alias
4932411G09Rik, AV277261, AW228608, h-warts, Kinase phosphorylated during mitosis protein, KPM, large tumor suppressor 2, large tumor suppressor homolog 2, large tumor suppressor kinase 2, large tumor suppressor, homolog 2, LATS (large tumor suppressor, Drosophila) homolog 2, LATS, large tumor suppressor, homolog 2, LATS2, serine/threonine kinase KPM, serine/threonine-protein kinase kpm, Serine/threonine-protein kinase LATS2, si:ch211-173o4.2, Warts-like kinase
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
26524, 305922, 50523
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q7TSJ6, Q9NRM7
Gene Symbols
LATS2
Immunogen
A synthesized peptide derived from human LATS2(Accession Q9NRM7), corresponding to amino acid residues S354-S404.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total LATS2
- LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family
- LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction
- LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity
- LATS2 plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
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Antigen: LATS2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: LATS2
Gene Alias: 4932411G09Rik, AV277261, AW228608, h-warts, Kinase phosphorylated during mitosis protein, KPM, large tumor suppressor 2, large tumor suppressor homolog 2, large tumor suppressor kinase 2, large tumor suppressor, homolog 2, LATS (large tumor suppressor, Drosophila) homolog 2, LATS, large tumor suppressor, homolog 2, LATS2, serine/threonine kinase KPM, serine/threonine-protein kinase kpm, Serine/threonine-protein kinase LATS2, si:ch211-173o4.2, Warts-like kinase
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 26524, 305922, 50523
Content And Storage: -20°C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q7TSJ6, Q9NRM7
Gene Symbols: LATS2
Immunogen: A synthesized peptide derived from human LATS2(Accession Q9NRM7), corresponding to amino acid residues S354-S404.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
LATS2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
LATS2
Gene Alias:
4932411G09Rik, AV277261, AW228608, h-warts, Kinase phosphorylated during mitosis protein, KPM, large tumor suppressor 2, large tumor suppressor homolog 2, large tumor suppressor kinase 2, large tumor suppressor, homolog 2, LATS (large tumor suppressor, Drosophila) homolog 2, LATS, large tumor suppressor, homolog 2, LATS2, serine/threonine kinase KPM, serine/threonine-protein kinase kpm, Serine/threonine-protein kinase LATS2, si:ch211-173o4.2, Warts-like kinase
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
26524, 305922, 50523
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q7TSJ6, Q9NRM7
Gene Symbols:
LATS2
Immunogen:
A synthesized peptide derived from human LATS2(Accession Q9NRM7), corresponding to amino acid residues S354-S404.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-nrf2 (Ser40)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: NFE2L2
Gene Alias: AI194320; E4TF1-60; E4TF1A; HEBP1; Nfe2l2; NF-E2-related factor 2; NFE2-related factor 2; NF-E2-related factor-2; NFT2; NRF2; NRF2A; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid 2-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid 2 like 2; nuclear factor, erythroid 2-like 2; nuclear factor, erythroid derived 2, like 2; Unknown (protein for IMAGE:7945830)
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 18024, 4780, 83619
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: O54968, Q16236, Q60795
Gene Symbols: NFE2L2
Immunogen: A synthesized peptide derived from human NFE2L2(Accession Q16236), corresponding to amino acid residues around phosphorylated Ser40.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-nrf2 (Ser40)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
NFE2L2
Gene Alias:
AI194320; E4TF1-60; E4TF1A; HEBP1; Nfe2l2; NF-E2-related factor 2; NFE2-related factor 2; NF-E2-related factor-2; NFT2; NRF2; NRF2A; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid 2-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid 2 like 2; nuclear factor, erythroid 2-like 2; nuclear factor, erythroid derived 2, like 2; Unknown (protein for IMAGE:7945830)
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
18024, 4780, 83619
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
O54968, Q16236, Q60795
Gene Symbols:
NFE2L2
Immunogen:
A synthesized peptide derived from human NFE2L2(Accession Q16236), corresponding to amino acid residues around phosphorylated Ser40.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: RAD21
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Rad21
Gene Alias: 64-kDa carboxy-terminal product; 64-kDa C-terminal product; 65-kDa carboxy-terminal product; CDLS4; double-strand-break repair protein rad21 homolog; double-strand-break repair protein rad21-like protein; FLJ25655; FLJ40596; h NXP-1; hHR21; HR21; HRAD21; KIAA0078; KIAA0078RAD21; kleisin; MCD1; mHR21; mKIAA0078; nuclear matrix protein 1; NXP1; NXP-1; Pokeweed agglutinin-binding protein 29; protein involved in DNA double-strand break repair; PW29; Rad21; RAD21 cohesin complex component; RAD21 homolog; RAD21 homolog (S. pombe); SCC1; SCC1 homolog; sister chromatid cohesion 1
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 19357, 5885
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: O60216, Q61550
Gene Symbols: Rad21
Immunogen: A synthesized peptide derived from human RAD21(Accession O60216), corresponding to amino acid residues K527-E577.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
RAD21
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Rad21
Gene Alias:
64-kDa carboxy-terminal product; 64-kDa C-terminal product; 65-kDa carboxy-terminal product; CDLS4; double-strand-break repair protein rad21 homolog; double-strand-break repair protein rad21-like protein; FLJ25655; FLJ40596; h NXP-1; hHR21; HR21; HRAD21; KIAA0078; KIAA0078RAD21; kleisin; MCD1; mHR21; mKIAA0078; nuclear matrix protein 1; NXP1; NXP-1; Pokeweed agglutinin-binding protein 29; protein involved in DNA double-strand break repair; PW29; Rad21; RAD21 cohesin complex component; RAD21 homolog; RAD21 homolog (S. pombe); SCC1; SCC1 homolog; sister chromatid cohesion 1
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
19357, 5885
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
O60216, Q61550
Gene Symbols:
Rad21
Immunogen:
A synthesized peptide derived from human RAD21(Accession O60216), corresponding to amino acid residues K527-E577.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: Claspin
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CLSPN
Gene Alias: B130025E01; C85083; claspin; claspin homolog; CLSPN; E130314M08Rik; hClaspin; MGC131612; MGC131613; MGC131615
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 269582, 298534, 63967
Content And Storage: -20°C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q80YR7, Q9HAW4
Gene Symbols: CLSPN
Immunogen: A synthesized peptide derived from human CLSPN(Accession Q9HAW4), corresponding to amino acid residues H10-K60.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Claspin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CLSPN
Gene Alias:
B130025E01; C85083; claspin; claspin homolog; CLSPN; E130314M08Rik; hClaspin; MGC131612; MGC131613; MGC131615
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
269582, 298534, 63967
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q80YR7, Q9HAW4
Gene Symbols:
CLSPN
Immunogen:
A synthesized peptide derived from human CLSPN(Accession Q9HAW4), corresponding to amino acid residues H10-K60.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG