PIPA5105065
Phospho-MST2 (Ser316) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105065-Each-of-1 | In Stock | ₹ 43,592.82 |
PIPA5105065 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,592.82
GST (18%): ₹ 7,846.708
Total Price: ₹ 51,439.528
Antigen
Phospho-MST2 (Ser316)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
STK3
Gene Alias
0610042I06Rik; KB-1458E12.1; KRS1; Mammalian STE20-like protein kinase 2; mess1; MST; Mst2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase Krs-1; Ste20; STE20-like kinase MST2; STK3; wu:fc19e11; zgc:55383
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
56274, 65189, 6788
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O54748, Q13188, Q9JI10
Gene Symbols
STK3
Immunogen
A synthesized peptide derived from human STK3(Accession Q13188), corresponding to amino acid residues around phosphorylated Ser316.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of STK3 only when phosphorylated at Ser316
- STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways, and is known to be activated by the proapoptotic stimuli staurosporine and FAS ligand
- STK3 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation
- It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
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Antigen: Phospho-MST2 (Ser316)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: STK3
Gene Alias: 0610042I06Rik; KB-1458E12.1; KRS1; Mammalian STE20-like protein kinase 2; mess1; MST; Mst2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase Krs-1; Ste20; STE20-like kinase MST2; STK3; wu:fc19e11; zgc:55383
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 56274, 65189, 6788
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: O54748, Q13188, Q9JI10
Gene Symbols: STK3
Immunogen: A synthesized peptide derived from human STK3(Accession Q13188), corresponding to amino acid residues around phosphorylated Ser316.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-MST2 (Ser316)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
STK3
Gene Alias:
0610042I06Rik; KB-1458E12.1; KRS1; Mammalian STE20-like protein kinase 2; mess1; MST; Mst2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase Krs-1; Ste20; STE20-like kinase MST2; STK3; wu:fc19e11; zgc:55383
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
56274, 65189, 6788
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
O54748, Q13188, Q9JI10
Gene Symbols:
STK3
Immunogen:
A synthesized peptide derived from human STK3(Accession Q13188), corresponding to amino acid residues around phosphorylated Ser316.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-WWTR1 (Ser89)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: WWTR1
Gene Alias: 2310058J06Rik; 2610021I22Rik; C78399; DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; TAZ; transcriptional coactivator with PDZ binding motif; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; Wwtr1
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 25937, 295062, 97064
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q9EPK5, Q9GZV5
Gene Symbols: WWTR1
Immunogen: A synthesized peptide derived from human WWTR1(Accession Q9GZV5), corresponding to amino acid residues around phosphorylated Ser89.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-WWTR1 (Ser89)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
WWTR1
Gene Alias:
2310058J06Rik; 2610021I22Rik; C78399; DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; TAZ; transcriptional coactivator with PDZ binding motif; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; Wwtr1
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
25937, 295062, 97064
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q9EPK5, Q9GZV5
Gene Symbols:
WWTR1
Immunogen:
A synthesized peptide derived from human WWTR1(Accession Q9GZV5), corresponding to amino acid residues around phosphorylated Ser89.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-WWTR1 (Ser66)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: WWTR1
Gene Alias: 2310058J06Rik; 2610021I22Rik; C78399; DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; TAZ; transcriptional coactivator with PDZ binding motif; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; Wwtr1
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 25937, 295062, 97064
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q9EPK5, Q9GZV5
Gene Symbols: WWTR1
Immunogen: A synthesized peptide derived from human WWTR1(Accession Q9GZV5), corresponding to amino acid residues around phosphorylated Ser66.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-WWTR1 (Ser66)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
WWTR1
Gene Alias:
2310058J06Rik; 2610021I22Rik; C78399; DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; TAZ; transcriptional coactivator with PDZ binding motif; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; Wwtr1
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
25937, 295062, 97064
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q9EPK5, Q9GZV5
Gene Symbols:
WWTR1
Immunogen:
A synthesized peptide derived from human WWTR1(Accession Q9GZV5), corresponding to amino acid residues around phosphorylated Ser66.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-53BP2 (Ser698)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TP53BP2
Gene Alias: 53BP2; Apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; ASPP2; BBP; Bcl2-binding protein; P PPP1R13A; P53BP2; PPP1R13A; Renal carcinoma antigen NY-REN-51; TP53BP2; transformation related protein 53 binding protein 2; Trp53bp2; tumor protein p53 binding protein 2; tumor protein p53 binding protein, 2; tumor suppressor p53-binding protein 2
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 305025, 7159
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q13625
Gene Symbols: TP53BP2
Immunogen: A synthesized peptide derived from human TP53BP2(Accession Q13625), corresponding to amino acid residues around phosphorylated Ser698.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-53BP2 (Ser698)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TP53BP2
Gene Alias:
53BP2; Apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; ASPP2; BBP; Bcl2-binding protein; P PPP1R13A; P53BP2; PPP1R13A; Renal carcinoma antigen NY-REN-51; TP53BP2; transformation related protein 53 binding protein 2; Trp53bp2; tumor protein p53 binding protein 2; tumor protein p53 binding protein, 2; tumor suppressor p53-binding protein 2
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
305025, 7159
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q13625
Gene Symbols:
TP53BP2
Immunogen:
A synthesized peptide derived from human TP53BP2(Accession Q13625), corresponding to amino acid residues around phosphorylated Ser698.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG