PIPA511352
MDM2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA511352-Each-of-1 | In Stock | ₹ 46,844.10 |
PIPA511352 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,844.10
GST (18%): ₹ 8,431.938
Total Price: ₹ 55,276.038
Antigen
MDM2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
4193
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.25 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q00987
Gene Symbols
MDM2
Immunogen
KLH conjugated synthetic peptide between 141-176 amino acids from human MDM2
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
Ig
Description
- MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human malignancies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
Compare Similar Items
Show Difference
Antigen: MDM2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography, Protein A
Regulatory Status: RUO
Gene ID (Entrez): 4193
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.25 mg/mL
Formulation: PBS with 0.09% sodium azide
Gene Accession No.: Q00987
Gene Symbols: MDM2
Immunogen: KLH conjugated synthetic peptide between 141-176 amino acids from human MDM2
Quantity: 400 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: Ig
Antigen:
MDM2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography, Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
4193
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.25 mg/mL
Formulation:
PBS with 0.09% sodium azide
Gene Accession No.:
Q00987
Gene Symbols:
MDM2
Immunogen:
KLH conjugated synthetic peptide between 141-176 amino acids from human MDM2
Quantity:
400 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
Ig
Antigen: SCN8A
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Scn8a
Gene Alias: AI853486; ataxia 3; C630029C19Rik; CERIII; CIAT; dmu; EIEE13; hNa6/Scn8a voltage-gated sodium channel; MED; mnd2; mnd-2; Na+ channel; naCh6; Nav1.6; Nbna1; nmf2; nmf335; nmf58; nur14; peripheral nerve protein type 4; PN4; SCN8A; Scn8a (PN4); seal; Sodium channel 6; sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel, voltage gated, type VIII alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type VIII, alpha; sodium channel, voltage-gated, type VIII, alpha polypeptide; sodium voltage-gated channel alpha subunit 8; voltage-gated sodium channel subunit alpha Nav1.6; voltage-gated sodium channel type VIII alpha protein
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 29710, 6334
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.53 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: O88420, Q9UQD0
Gene Symbols: Scn8a
Immunogen: Recombinant Human Sodium channel protein type 8 subunit alpha protein (1350-1440AA)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SCN8A
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Scn8a
Gene Alias:
AI853486; ataxia 3; C630029C19Rik; CERIII; CIAT; dmu; EIEE13; hNa6/Scn8a voltage-gated sodium channel; MED; mnd2; mnd-2; Na+ channel; naCh6; Nav1.6; Nbna1; nmf2; nmf335; nmf58; nur14; peripheral nerve protein type 4; PN4; SCN8A; Scn8a (PN4); seal; Sodium channel 6; sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel, voltage gated, type VIII alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type VIII, alpha; sodium channel, voltage-gated, type VIII, alpha polypeptide; sodium voltage-gated channel alpha subunit 8; voltage-gated sodium channel subunit alpha Nav1.6; voltage-gated sodium channel type VIII alpha protein
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
29710, 6334
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid
Applications:
ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.53 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
O88420, Q9UQD0
Gene Symbols:
Scn8a
Immunogen:
Recombinant Human Sodium channel protein type 8 subunit alpha protein (1350-1440AA)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: FBXO3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: FBXO3
Gene Alias: 1200002G09Rik; 1700026K02Rik; AI046358; DKFZp564B092; FBA; F-box only protein 3; F-box protein 3; F-box protein FBA; F-box protein FBX3; FBX3; FBXO3
Host Species: Rabbit
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 26273, 57443
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Applications: ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 4 mg/mL
Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.: Q9DC63, Q9UK99
Gene Symbols: FBXO3
Immunogen: Recombinant Human F-box only protein 3 protein (276-376AA)
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
FBXO3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
FBXO3
Gene Alias:
1200002G09Rik; 1700026K02Rik; AI046358; DKFZp564B092; FBA; F-box only protein 3; F-box protein 3; F-box protein FBA; F-box protein FBX3; FBX3; FBXO3
Host Species:
Rabbit
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
26273, 57443
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid
Applications:
ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
4 mg/mL
Formulation:
PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.:
Q9DC63, Q9UK99
Gene Symbols:
FBXO3
Immunogen:
Recombinant Human F-box only protein 3 protein (276-376AA)
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: DIMT1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DIMT1
Gene Alias: 1500031M22Rik; 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; 18S rRNA dimethylase; AV111347; DIM1; DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); DIM1 dimethyladenosine transferase 1-like; DIM1 dimethyladenosine transferase 1-like (S. cerevisiae); dimethyladenosine transferase; Dimt1; Dimt1l; HSA9761; HUSSY-05; HUSSY5; probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; Probable 18S rRNA dimethylase; probable dimethyladenosine transferase; Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase; RGD1311752; S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
Host Species: Rabbit
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 27292, 66254
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration: 3 mg/mL
Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.: Q9D0D4, Q9UNQ2
Gene Symbols: DIMT1
Immunogen: Recombinant Human Probable dimethyladenosine transferase protein (1-313AA)
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
DIMT1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DIMT1
Gene Alias:
1500031M22Rik; 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; 18S rRNA dimethylase; AV111347; DIM1; DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); DIM1 dimethyladenosine transferase 1-like; DIM1 dimethyladenosine transferase 1-like (S. cerevisiae); dimethyladenosine transferase; Dimt1; Dimt1l; HSA9761; HUSSY-05; HUSSY5; probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; Probable 18S rRNA dimethylase; probable dimethyladenosine transferase; Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase; RGD1311752; S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
Host Species:
Rabbit
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
27292, 66254
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid
Applications:
ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration:
3 mg/mL
Formulation:
PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.:
Q9D0D4, Q9UNQ2
Gene Symbols:
DIMT1
Immunogen:
Recombinant Human Probable dimethyladenosine transferase protein (1-313AA)
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG