PIPA5114665
Phospho-TLR3 (Tyr858) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5114665-Each-of-1 | In Stock | ₹ 44,191.74 |
PIPA5114665 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,191.74
GST (18%): ₹ 7,954.513
Total Price: ₹ 52,146.253
Antigen
Phospho-TLR3 (Tyr858)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TLR3
Gene Alias
AI957183; CD283; IIAE2; TLR 3; TLR3; TLR-3; toll like receptor 3; toll-like receptor 3; toll-like receptor 3 variant 1
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
142980, 7098
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.
O15455, Q99MB1
Gene Symbols
TLR3
Immunogen
A synthesized peptide derived from human TLR3 around the phosphorylation site of Tyr858.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of TLR3 only when phosphorylated at Tyr858
- TLR3 (Toll-like receptor 3, CD283) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity
- TLRs are highly conserved from drosophila to humans and share structural and functional similarities
- TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity
- The various TLRs exhibit different patterns of expression
- TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes
- TLR3 recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons
- Further, TLR3 may play a role in host defense against viruses, and the use of alternative polyadenylation sites to generate different length transcripts has been noted for the TLR3 gene
- Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans
- The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition
- TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway
- TLR3 is the only human TLR which does not utilize MyD88 as an adaptor molecule instead utilizing TRIF in a signaling path which results in downstream activation of IRF-3 and NF-kB
- TLR3 activation leads not only to Type I interferon induction but also to other inflammatory cytokines which result in DC maturation
- TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection
- Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.
Compare Similar Items
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Antigen: Phospho-TLR3 (Tyr858)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TLR3
Gene Alias: AI957183; CD283; IIAE2; TLR 3; TLR3; TLR-3; toll like receptor 3; toll-like receptor 3; toll-like receptor 3 variant 1
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 142980, 7098
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.: O15455, Q99MB1
Gene Symbols: TLR3
Immunogen: A synthesized peptide derived from human TLR3 around the phosphorylation site of Tyr858.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-TLR3 (Tyr858)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TLR3
Gene Alias:
AI957183; CD283; IIAE2; TLR 3; TLR3; TLR-3; toll like receptor 3; toll-like receptor 3; toll-like receptor 3 variant 1
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
142980, 7098
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.:
O15455, Q99MB1
Gene Symbols:
TLR3
Immunogen:
A synthesized peptide derived from human TLR3 around the phosphorylation site of Tyr858.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-TOPBP1 (Ser1138)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TOPBP1
Gene Alias: 1110031N14Rik; 2810429C13Rik; AI256758; D430026L04Rik; DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; KIAA0259; mKIAA0259; RGD1562949; TOP2BP1; TOPBP 1; Topbp1; topoisomerase (DNA) II beta binding protein; topoisomerase (DNA) II binding protein 1
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11073, 235559, 315969
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.: Q6ZQF0, Q92547
Gene Symbols: TOPBP1
Immunogen: A synthesized peptide derived from human TOPBP1 around the phosphorylation site of Ser1138.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-TOPBP1 (Ser1138)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TOPBP1
Gene Alias:
1110031N14Rik; 2810429C13Rik; AI256758; D430026L04Rik; DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; KIAA0259; mKIAA0259; RGD1562949; TOP2BP1; TOPBP 1; Topbp1; topoisomerase (DNA) II beta binding protein; topoisomerase (DNA) II binding protein 1
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11073, 235559, 315969
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.:
Q6ZQF0, Q92547
Gene Symbols:
TOPBP1
Immunogen:
A synthesized peptide derived from human TOPBP1 around the phosphorylation site of Ser1138.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-TSC2 (Ser939)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TSC2
Gene Alias: LAM; Nafld; OTTHUMP00000198394; PPP1R160; protein phosphatase 1, regulatory subunit 160; Rc; renal carcinoma; Tcs2; Tsc2; TSC4; Tuberin; tuberous sclerosis 2; tuberous sclerosis 2 homolog protein; tuberous sclerosis 2 protein; Tuberous sclerosis 2 protein homolog
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 22084, 24855, 7249
Content And Storage: -20°C
Form: Liquid
Applications: Immunohistochemistry (PFA fixed), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.: P49815, P49816, Q61037
Gene Symbols: TSC2
Immunogen: A synthesized peptide derived from human TSC2(Accession P49815), corresponding to amino acid residues around phosphorylated Ser939.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-TSC2 (Ser939)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TSC2
Gene Alias:
LAM; Nafld; OTTHUMP00000198394; PPP1R160; protein phosphatase 1, regulatory subunit 160; Rc; renal carcinoma; Tcs2; Tsc2; TSC4; Tuberin; tuberous sclerosis 2; tuberous sclerosis 2 homolog protein; tuberous sclerosis 2 protein; Tuberous sclerosis 2 protein homolog
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22084, 24855, 7249
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunohistochemistry (PFA fixed), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.:
P49815, P49816, Q61037
Gene Symbols:
TSC2
Immunogen:
A synthesized peptide derived from human TSC2(Accession P49815), corresponding to amino acid residues around phosphorylated Ser939.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-UBA52 (Ser65)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: UBA52
Gene Alias: 60S ribosomal protein L40; CEP52; D8Ertd21e; Gm1863; HUB L40; HUBCEP52; L40; Large ribosomal subunit protein eL40; MGC127041; RPL40; RPS27A; Uba52; UBB; Ubc; Ubcep2; Ubiquitin; Ubiquitin A-52 residue ribosomal protein fusion product 1; ubiquitin and ribosomal protein L40; ubiquitin carboxyl extension protein 52; ubiquitin/60S ribosomal fusion protein; ubiquitin-52 amino acid fusion protein; ubiquitin-60S ribosomal protein L40; ubiquitin-CEP52; Unknown (protein for MGC:127041)
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 22186, 64156, 7311
Content And Storage: -20°C
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.: P62984, P62986, P62987
Gene Symbols: UBA52
Immunogen: A synthesized peptide derived from human UBA52 around the phosphorylation site of Ser65.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-UBA52 (Ser65)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
UBA52
Gene Alias:
60S ribosomal protein L40; CEP52; D8Ertd21e; Gm1863; HUB L40; HUBCEP52; L40; Large ribosomal subunit protein eL40; MGC127041; RPL40; RPS27A; Uba52; UBB; Ubc; Ubcep2; Ubiquitin; Ubiquitin A-52 residue ribosomal protein fusion product 1; ubiquitin and ribosomal protein L40; ubiquitin carboxyl extension protein 52; ubiquitin/60S ribosomal fusion protein; ubiquitin-52 amino acid fusion protein; ubiquitin-60S ribosomal protein L40; ubiquitin-CEP52; Unknown (protein for MGC:127041)
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22186, 64156, 7311
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.:
P62984, P62986, P62987
Gene Symbols:
UBA52
Immunogen:
A synthesized peptide derived from human UBA52 around the phosphorylation site of Ser65.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG