PIPA5116527
IkB alpha Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5116527-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA5116527 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
IkB alpha
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NFKBIA
Gene Alias
AI462015; ECI-6; ECI-6/IKBA; I kappa B-alpha; I(Kappa)B(alpha); I79_018146; IkappaB alpha; IkappaBalpha; I-kappaBalpha; I-kappa-B-alpha; Ikba; IKBalpha; IKB-alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha; MAD3; MAD-3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappaB inhibitor alpha; NF-kappa-B inhibitor alpha; NFKB inhibitor alpha; NFKBI; Nfkbia; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Rel-associated pp40; REL-associated protein pp40; RL/IF-1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18035, 25493
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.06 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q63746, Q9Z1E3
Gene Symbols
NFKBIA
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human IκB alpha (NP_0653901)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Mouse thymus, Rat thymus, HeLa Immunogen sequence: MFQAAERPQE WAMEGPRDGL KKERLLDDRH DSGLDSMKDE EYEQMVKELQ EIRLEPQEVP RGSEPWKQQL TEDGDSFLHL AIIHEEKALT MEVIRQVKGD LAFLNFQNNL QQTPLHLAVI TNQPEIAEAL LGAGCDPELR DFRGNTPLHL ACEQGCLASV GVLTQSCTTP HLHSILKATN YNGHTCLHLA SIHGYLGIVE LLVSLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG ADVNRVTYQG YSPYQLTWGR PSTRIQQQLG QLTLENLQML PESEDEESYD TESEFTEFTE DELPYDDCVF GGQRLTL IkB-alpha is a 40 kDa protein that functions to inhibit NF- kappaB activity
- The inhibition occurs via protein-protein interaction between I kappaB proteins and NF- kappaB dimers in the cytosol
- The interaction of I kappa B-alpha with NF- kappaB masks the nuclear localization sequence of NF- kappaB, preventing NF- kappaB translocation to the nucleus
- A variety of stimuli can activate gene expression by liberating NF- kappaB through the degradation of I kappaB alpha
- These stimuli include the proinflammatory cytokines TNF- alpha and IL-1 beta, chemokines, PMA, growth factors, LPS, UV irradiation, viral infection, as well as various chemical and physical stresses
- In humans, the gene is located on the q arm of chromosome 14
- Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB
- IkB kinase alpha (IKK alpha), previously designated CHUK, interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation Serines 32 and 36
- IKK alpha appears to be critical for NFkB activation in response to proinflammatory cytokines
- Phosphorylation of IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1
- The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma, and each appear to make essential contributions to IkB phosphorylation.
Compare Similar Items
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Antigen: IkB alpha
Classification: Polyclonal
Conjugate: Unconjugated
Gene: NFKBIA
Gene Alias: AI462015; ECI-6; ECI-6/IKBA; I kappa B-alpha; I(Kappa)B(alpha); I79_018146; IkappaB alpha; IkappaBalpha; I-kappaBalpha; I-kappa-B-alpha; Ikba; IKBalpha; IKB-alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha; MAD3; MAD-3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappaB inhibitor alpha; NF-kappa-B inhibitor alpha; NFKB inhibitor alpha; NFKBI; Nfkbia; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Rel-associated pp40; REL-associated protein pp40; RL/IF-1
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 18035, 25493
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.06 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q63746, Q9Z1E3
Gene Symbols: NFKBIA
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human IκB alpha (NP_0653901)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
IkB alpha
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
NFKBIA
Gene Alias:
AI462015; ECI-6; ECI-6/IKBA; I kappa B-alpha; I(Kappa)B(alpha); I79_018146; IkappaB alpha; IkappaBalpha; I-kappaBalpha; I-kappa-B-alpha; Ikba; IKBalpha; IKB-alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha; MAD3; MAD-3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappaB inhibitor alpha; NF-kappa-B inhibitor alpha; NFKB inhibitor alpha; NFKBI; Nfkbia; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Rel-associated pp40; REL-associated protein pp40; RL/IF-1
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
18035, 25493
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.06 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q63746, Q9Z1E3
Gene Symbols:
NFKBIA
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human IκB alpha (NP_0653901)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: ERK2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MAPK1
Gene Alias: 9030612K14Rik; AA407128; AU018647; C78273; ERK; ERK2; ERK-2; ERT1; extracellular signal-regulated kinase 2; extracellular signal-regulated kinase-2; extracellular-signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; Mapk; MAPK 1; MAPK 2; Mapk1; MAPK2; mitogen activated protein kinase 1; mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; p38; p40; p41; p41mapk; P42MAPK; p42-MAPK; Prkm1; PRKM2; protein tyrosine kinase ERK2
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 116590, 26413, 5594
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.93 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.: P28482, P63085, P63086
Gene Symbols: MAPK1
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ERK2 (NP_0027363)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
ERK2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MAPK1
Gene Alias:
9030612K14Rik; AA407128; AU018647; C78273; ERK; ERK2; ERK-2; ERT1; extracellular signal-regulated kinase 2; extracellular signal-regulated kinase-2; extracellular-signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; Mapk; MAPK 1; MAPK 2; Mapk1; MAPK2; mitogen activated protein kinase 1; mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; p38; p40; p41; p41mapk; P42MAPK; p42-MAPK; Prkm1; PRKM2; protein tyrosine kinase ERK2
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
116590, 26413, 5594
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.93 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.:
P28482, P63085, P63086
Gene Symbols:
MAPK1
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ERK2 (NP_0027363)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CRF
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CRH
Gene Alias: Corticoliberin; corticotropin releasing factor; corticotropin releasing hormone; corticotropin releasing hormone receptor 2; corticotropin-releasing factor; Corticotropin-releasing factor receptor 2; corticotropin-releasing hormone; Corticotropin-releasing hormone receptor 2; CRF; CRF2; CRF2 receptor, beta isoform; CRF2R; CRFR2; CRF-R-2; CRF-RB; CRH; CRH receptor 2 variant B; CRH1; CRH2R; CRHR2; CRH-R2; CRH-R-2; Gm1347; HM-CRF
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12918, 1392, 81648
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P01143, P06850, Q8CIT0
Gene Symbols: CRH
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-194 of human CRH (NP_0007471)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
CRF
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CRH
Gene Alias:
Corticoliberin; corticotropin releasing factor; corticotropin releasing hormone; corticotropin releasing hormone receptor 2; corticotropin-releasing factor; Corticotropin-releasing factor receptor 2; corticotropin-releasing hormone; Corticotropin-releasing hormone receptor 2; CRF; CRF2; CRF2 receptor, beta isoform; CRF2R; CRFR2; CRF-R-2; CRF-RB; CRH; CRH receptor 2 variant B; CRH1; CRH2R; CRHR2; CRH-R2; CRH-R-2; Gm1347; HM-CRF
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12918, 1392, 81648
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P01143, P06850, Q8CIT0
Gene Symbols:
CRH
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-194 of human CRH (NP_0007471)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: SIRT1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SIRT1
Gene Alias: 75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2; Sir2a; SIR2alpha; SIR2L1; sir2-like 1; SIR2-like protein 1; SIRT 1; SIRT1; SIRT-1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23411, 309757, 93759
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 2.92 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.: A0A0G2JZ79, Q923E4, Q96EB6
Gene Symbols: SIRT1
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 448-747 of human SIRT1 (NP_0363702)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SIRT1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SIRT1
Gene Alias:
75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2; Sir2a; SIR2alpha; SIR2L1; sir2-like 1; SIR2-like protein 1; SIRT 1; SIRT1; SIRT-1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23411, 309757, 93759
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
2.92 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
A0A0G2JZ79, Q923E4, Q96EB6
Gene Symbols:
SIRT1
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 448-747 of human SIRT1 (NP_0363702)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG