PIPA5118572

Phospho-IRF3 (Ser386) Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 PIPA5118572-Each-of-1 In Stock ₹ 41,539.38

PIPA5118572 - Each of 1

₹ 41,539.38

In Stock

Quantity

1

Base Price: ₹ 41,539.38

GST (18%): ₹ 7,477.088

Total Price: ₹ 49,016.468

Antigen

Phospho-IRF3 (Ser386)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

IRF3

Gene Alias

C920001K05Rik; IIAE7; Interferon regulatory factor 3; IRF3; IRF-3; IRF3 (phospho S386); IRF3 (pS386); IRF3 (pSer386); IRF3 phospho; IRF3 phospho S386; IRF3 phospho Ser386; phospho IRF3

Host Species

Rabbit

Purification Method

sequential chromatography

Regulatory Status

RUO

Gene ID (Entrez)

292892, 3661

Content And Storage

-20°C

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration

1 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.

Q14653

Gene Symbols

IRF3

Immunogen

A synthesized peptide derived from human IRF3(Accession Q14653), corresponding to amino acid residues around phosphorylated Ser386.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • Antibody detects endogenous levels of IRF3 only when phosphorylated at Serine 386
  • IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses
  • It plays a critical role in the innate immune response against DNA and RNA viruses
  • IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters
  • It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction
  • IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling
  • It is phosphorylated by IKBKE and TBK1 kinases
  • This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes
  • Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIPA5118572

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Antigen:
Phospho-IRF3 (Ser386)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
IRF3

Gene Alias:
C920001K05Rik; IIAE7; Interferon regulatory factor 3; IRF3; IRF-3; IRF3 (phospho S386); IRF3 (pS386); IRF3 (pSer386); IRF3 phospho; IRF3 phospho S386; IRF3 phospho Ser386; phospho IRF3

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
292892, 3661

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
Q14653

Gene Symbols:
IRF3

Immunogen:
A synthesized peptide derived from human IRF3(Accession Q14653), corresponding to amino acid residues around phosphorylated Ser386.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Rat

Product Type:
Antibody

Isotype:
IgG

Img

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PIPA5118586

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Antigen:
Phospho-FGFR1/FGFR2 (Tyr463, Tyr466)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
FGFR2

Gene Alias:
AU043015; AW208770; AW556123; bacteria-expressed kinase; basic fibroblast growth factor receptor 1; BBDS; BEK; BEK fibroblast growth factor receptor; BFGFR; bFGF-R; bFGF-R-1; BFR-1; CD331; CD332; CEK; CEK3; CFD1; c-fgr; Eask; ECCL; ECT1; FGF Receptor 2; FGF receptor-1; FGFBR; fgfr 1; Fgfr1; Fgfr-1; FGFR1/PLAG1 fusion; FGFR2; Fgfr-2; Fgfr7; Fgfr-7; Fibroblast growth factor receptor 1; fibroblast growth factor receptor 2; FLG; FLT2; FLT-2; Fms-like tyrosine kinase 2; fms-related tyrosine kinase 2; HBGFR; heparin-binding growth factor receptor; HH2; HRTFDS; Hspy; hydroxyaryl-protein kinase; JWS; KAL2; Keratinocyte growth factor receptor; KGFR; KGFRTr; KSAM; K-SAM; MFR; N-sam; OGD; protein tyrosine kinase, receptor like 14; proto-oncogene c-Fgr; Soluble KGFR; svs; TK14; TK25

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
14182, 14183, 2260, 2263, 25022, 79114

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P11362, P16092, P21802, P21803, Q04589

Gene Symbols:
FGFR1, FGFR2

Immunogen:
A synthesized peptide derived from human FGFR1/2 around the phosphorylation site of Tyr463/466.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

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PIPA5118589

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Antigen:
NDUFA4

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
NDUFA4

Gene Alias:
CI-9k; CI-MLRQ; Complex I 9kDa subunit; complex I-MLRQ; Cytochrome c oxidase subunit NDUFA4; EC 1.6.5.3; EC 1.6.99.3; MLRQ; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4 (9 kDa, MLRQ); NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4; NADH-ubiquinone oxidoreductase MLRQ subunit; NDUFA4; NDUFA4, mitochondrial complex associated

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
17992, 4697, 681024

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
O00483, Q62425

Gene Symbols:
NDUFA4

Immunogen:
A synthesized peptide derived from human NDUFA4(Accession O00483), corresponding to amino acid residues N48-F81.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

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PIPA5118590

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Antigen:
ITGB5

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Itgb5

Gene Alias:
[b]5; [b]-5; [b]5A; [b]5B; AA475909; AI874634; beta5; beta-5; CD61; ESTM23; FLJ26658; GP3A; GPIIIa; I79_000655; integrin beta 5; integrin beta-5; integrin subunit beta 5; integrin, beta 5; ITGB5; RGD1563276; testis secretory sperm-binding protein Li 217p

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
16419, 257645, 3693

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
O70309, P18084

Gene Symbols:
Itgb5

Immunogen:
A synthesized peptide derived from human ITGB5(Accession P18084), corresponding to amino acid residues A726-K776.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Non-human Primate, Rat

Product Type:
Antibody

Isotype:
IgG