PIPA5121290
Phospho-Chk1 (Ser345) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5121290-Each-of-1 | In Stock | ₹ 43,079.46 |
PIPA5121290 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,079.46
GST (18%): ₹ 7,754.303
Total Price: ₹ 50,833.763
Antigen
Phospho-Chk1 (Ser345)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Chek1
Gene Alias
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1111, 12649, 140583
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.27 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
O14757, O35280, Q91ZN7
Gene Symbols
Chek1
Immunogen
A synthetic phosphorylated peptide around S345 of human Chk1 (NP_001265.2).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive test controls include: HT-29, HepG2, C6
- The target is usually found in the following locations: Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center
- Immunogen sequence: SFSQP CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised
- CHK1 is a key mediator in the DNA damage-induced checkpoint network
- CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress
- When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase
- Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
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Antigen: Phospho-Chk1 (Ser345)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Chek1
Gene Alias: C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1111, 12649, 140583
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.27 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.: O14757, O35280, Q91ZN7
Gene Symbols: Chek1
Immunogen: A synthetic phosphorylated peptide around S345 of human Chk1 (NP_001265.2).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-Chk1 (Ser345)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Chek1
Gene Alias:
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1111, 12649, 140583
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.27 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.:
O14757, O35280, Q91ZN7
Gene Symbols:
Chek1
Immunogen:
A synthetic phosphorylated peptide around S345 of human Chk1 (NP_001265.2).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-GSK3 alpha (Ser21)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Gsk3a
Gene Alias: 2700086H06Rik; DKFZp686D0638; FA; factor A; glycogen synthase kinase 3 alpha; glycogen synthase kinase 3 alpha b; glycogen synthase kinase 3 alpha b; glycogen synthase kinase-3 alpha; glycogen synthase kinase-3 alpha; GSK3; GSK-3 alpha; GSK-3[a]; GSK-3[b]; gsk3a; gsk3ab; gsk-3-alpha; OTTHUMP00000198368; Serine/threonine-protein kinase GSK3A
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 2931
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Concentration: 0.82 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.: P49840
Gene Symbols: Gsk3a
Immunogen: A synthetic phosphorylated peptide around S21 of human GSK3alpha (NP_0639372)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-GSK3 alpha (Ser21)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Gsk3a
Gene Alias:
2700086H06Rik; DKFZp686D0638; FA; factor A; glycogen synthase kinase 3 alpha; glycogen synthase kinase 3 alpha b; glycogen synthase kinase 3 alpha b; glycogen synthase kinase-3 alpha; glycogen synthase kinase-3 alpha; GSK3; GSK-3 alpha; GSK-3[a]; GSK-3[b]; gsk3a; gsk3ab; gsk-3-alpha; OTTHUMP00000198368; Serine/threonine-protein kinase GSK3A
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
2931
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Concentration:
0.82 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.:
P49840
Gene Symbols:
Gsk3a
Immunogen:
A synthetic phosphorylated peptide around S21 of human GSK3alpha (NP_0639372)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-DNA-PK (Ser2056)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PRKDC
Gene Alias: AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5591
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 0.51 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.: P78527
Gene Symbols: PRKDC
Immunogen: A synthetic phosphorylated peptide around S2056 of human DNA-PKcs (NP_0088355)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-DNA-PK (Ser2056)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PRKDC
Gene Alias:
AI326420; AU019811; DNA-dependent protein kinase catalytic subunit; DNAPDcs; DNAPK; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; DOXNPH; doxorubicin nephropathy; dxnph; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; I79_017613; IMD26; p350; p460; Prkdc; protein kinase, DNA activated, catalytic polypeptide; protein kinase, DNA-activated, catalytic polypeptide; scid; severe combined immunodeficiency; slip; Xrcc7
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5591
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
0.51 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.:
P78527
Gene Symbols:
PRKDC
Immunogen:
A synthetic phosphorylated peptide around S2056 of human DNA-PKcs (NP_0088355)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-ULK1 (Ser757)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ULK1
Gene Alias: APG1; ATG 1; ATG1; ATG1 autophagy related 1 homolog; ATG1A; AU041434; Autophagy-related protein 1 homolog; C. elegans; EC:2.7.11.1; FLJ38455; hATG1; KIAA0722; mKIAA0722; Serine/threonine-protein kinase ULK1; serine/threonine-protein kinase Unc51.1; ULK 1; Ulk1; UNC 51; UNC51; unc-51 like autophagy activating kinase 1; unc-51 like kinase 1; Unc51.1; unc-51-like kinase 1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 8408
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 0.56 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.: O75385
Gene Symbols: ULK1
Immunogen: A synthetic phosphorylated peptide around S757 of human Phospho-ULK1-S757 (NP_0035561)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-ULK1 (Ser757)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ULK1
Gene Alias:
APG1; ATG 1; ATG1; ATG1 autophagy related 1 homolog; ATG1A; AU041434; Autophagy-related protein 1 homolog; C. elegans; EC:2.7.11.1; FLJ38455; hATG1; KIAA0722; mKIAA0722; Serine/threonine-protein kinase ULK1; serine/threonine-protein kinase Unc51.1; ULK 1; Ulk1; UNC 51; UNC51; unc-51 like autophagy activating kinase 1; unc-51 like kinase 1; Unc51.1; unc-51-like kinase 1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
8408
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
0.56 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.:
O75385
Gene Symbols:
ULK1
Immunogen:
A synthetic phosphorylated peptide around S757 of human Phospho-ULK1-S757 (NP_0035561)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG