PIPA513079

Phospho-Nanog (Ser285) Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 PIPA513079-Each-of-1 In Stock ₹ 44,790.66

PIPA513079 - Each of 1

₹ 44,790.66

In Stock

Quantity

1

Base Price: ₹ 44,790.66

GST (18%): ₹ 8,062.319

Total Price: ₹ 52,852.979

Antigen

Phospho-Nanog (Ser285)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

NANOG

Gene Alias

2410002E02Rik; early embryo specific expression NK family; early embryo specific expression NK-type homeobox protein; Ecat4; ENK; ES cell-associated protein 4; FLJ12581; HGNC:20857; hNanog; Homeobox protein NANOG; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; Nanog; Nanog homeobox

Host Species

Rabbit

Purification Method

Antigen affinity chromatography, Protein A

Regulatory Status

RUO

Gene ID (Entrez)

79923

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Dot Blot

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide

Gene Accession No.

Q9H9S0

Gene Symbols

NANOG

Immunogen

KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S285 of human Nanog

Quantity

400 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

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Description

  • NANOG (Nanog homeobox) is a divergent homeodomain protein that directs pluripotency and differentiation of undifferentiated embryonic stem cells
  • NANOG mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells
  • Human NANOG protein shares 52% overall amino acid identity with the mouse protein, and 85% identity in the homeodomain
  • Human NANOG maps to gene locus 12p13.31, while the mouse NANOG maps to gene loci 6 F2
  • Murine embryonic NANOG expression is detected in the inner cell mass of the blastocyst
  • Research studies have shown that high levels of human NANOG expression in the undifferentiated N-Tera embryonal carcinoma cell line
  • Further, NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal
  • The role of NANOG in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases
  • Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 (also known as Oct-4), another germline-specific transcription factor, and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts
  • Experiments have demonstrated that iPS cells could be generated using expression plasmids expressing NANOG, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine
  • When overexpressed, NANOG promotes cells to enter into S phase and proliferation
  • Diseases associated with dysfunction in the NANOG protein include tetracarcinoma and germ cell/embryonal cancer.

Compare Similar Items

Show Difference

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Thermo Scientific

PIPA513079

--


Antigen:
Phospho-Nanog (Ser285)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
NANOG

Gene Alias:
2410002E02Rik; early embryo specific expression NK family; early embryo specific expression NK-type homeobox protein; Ecat4; ENK; ES cell-associated protein 4; FLJ12581; HGNC:20857; hNanog; Homeobox protein NANOG; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; Nanog; Nanog homeobox

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography, Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
79923

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Dot Blot

Concentration:
0.5 mg/mL

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
Q9H9S0

Gene Symbols:
NANOG

Immunogen:
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S285 of human Nanog

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

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PIPA513105

--


Antigen:
ABCB11

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
ABCB11

Gene Alias:
ABC member 16, MDR/TAP subfamily; ABC16; Abcb11; ATP binding cassette subfamily B member 11; ATP-binding cassette sub-family B member 11; ATP-binding cassette, subfamily B (MDR/TAP), member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, sub-family B, member 11; bile salt export pump; BRIC2; Bsep; Lith1; PFIC2; PFIC-2; PGY4; progressive familial intrahepatic cholestasis 2; sister of P-glycoprotein; sister p-glycoprotein; Spgp

Host Species:
Rabbit

Purification Method:
Ammonium sulfate precipitation, Size-exclusion - Dialysis

Regulatory Status:
RUO

Gene ID (Entrez):
27413, 8647

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Concentration:
2 mg/mL

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
O95342, Q9QY30

Gene Symbols:
ABCB11

Immunogen:
KLH conjugated synthetic peptide between 1038-1067 amino acids from the C-terminal region of human ABCB11

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

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PIPA513111

--


Antigen:
HAND2

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
HAND2

Gene Alias:
AI225906; AI661148; basic helix-loop-helix transcription factor HAND2; bHLHa26; Class A basic helix-loop-helix protein 26; deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; DHAND; dHAND basic helix-loop-helix transcription factor; dHand protein; DHAND2; Ehand2; han; Hand2; hands off; heart and neural crest derivatives expressed 2; heart and neural crest derivatives expressed transcript 2; heart- and neural crest derivatives-expressed protein 2; Hed; helix-loop-helix transcription factor expressed in embryo and deciduum; Th2; Thing2; thing-2; zdHAND; zgc:103415

Host Species:
Rabbit

Purification Method:
Ammonium sulfate precipitation, Size-exclusion - Dialysis

Regulatory Status:
RUO

Gene ID (Entrez):
9464

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Concentration:
2 mg/mL

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
P61296

Gene Symbols:
HAND2

Immunogen:
KLH conjugated synthetic peptide between 179-207 amino acids from the C-terminal region of human HAND2

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

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PIPA513114

--


Antigen:
ABCB5

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
ABCB5

Gene Alias:
9230106F14Rik; ABCB5; ABCB5 P-gp; ABCB5alpha; ABCB5beta; ATP binding cassette subfamily B member 5; ATP-binding cassette protein; ATP-binding cassette sub-family B member 5; ATP-binding cassette, subfamily B (MDR/TAP), member 5; ATP-binding cassette, sub-family B (MDR/TAP), member 5; EST422562; P-glycoprotein ABCB5; RGD1566342

Host Species:
Rabbit

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
340273

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Flow Cytometry, Western Blot

Concentration:
0.4 mg/mL

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
Q2M3G0

Gene Symbols:
ABCB5

Immunogen:
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ABCB5

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG