PIPA514445

CDK4 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA514445-Each-of-1 In Stock ₹ 47,271.90

PIPA514445 - Each of 1

₹ 47,271.90

In Stock

Quantity

1

Base Price: ₹ 47,271.90

GST (18%): ₹ 8,508.942

Total Price: ₹ 55,780.842

Antigen

CDK4

Classification

Polyclonal

Formulation

PBS with 0.09% sodium azide

Gene Accession No.

P11802

Gene Symbols

Cdk4

Immunogen

KLH conjugated synthetic peptide between 273-305 amino acids from the C-terminal region of human CDK4

Quantity

400 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Applications

Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Conjugate

Unconjugated

Gene

Cdk4

Gene Alias

Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; p34<PSK-J3>/cdk4; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903)

Host Species

Rabbit

Purification Method

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Regulatory Status

RUO

Gene ID (Entrez)

1019

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

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Description

  • CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex
  • CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle
  • CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2)
  • CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex
  • CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins
  • SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2
  • Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.

Compare Similar Items

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Img

Thermo Scientific

PIPA514445

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Antigen:
CDK4

Classification:
Polyclonal

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
P11802

Gene Symbols:
Cdk4

Immunogen:
KLH conjugated synthetic peptide between 273-305 amino acids from the C-terminal region of human CDK4

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Conjugate:
Unconjugated

Gene:
Cdk4

Gene Alias:
Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; p34<PSK-J3>/cdk4; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903)

Host Species:
Rabbit

Purification Method:
Ammonium sulfate precipitation, Size-exclusion - Dialysis

Regulatory Status:
RUO

Gene ID (Entrez):
1019

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Img

Thermo Scientific

PIPA514456

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Antigen:
p21

Classification:
Polyclonal

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
P38936

Gene Symbols:
CDKN1A

Immunogen:
KLH conjugated synthetic peptide between 134-164 amino acids from the C-terminal region of human p21 (CDKN1A)

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Conjugate:
Unconjugated

Gene:
CDKN1A

Gene Alias:
Activating Fragment 1; CAP20; cdk inhibitor CIP1; cdk inhibitor CIP1 (p21); CDKI; CDK-interacting protein 1; CDK-interaction protein 1; Cdkn1; CDKN1A; CDNK1A; CIP1; Cip1); cyclin dependent kinase inhibitor 1A; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A; Cyclin-dependent kinase inhibitor 1A (p21; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; DNA synthesis inhibitor; MDA6; MDA-6; melanoma differentiation associated protein 6; melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; OTTHUMP00000016298; p21; p21<WAF1/CIP1>; p21Cip1; p21Cip1/Waf1; p21WAF; PIC1; putative cyclin-dependent kinase inhibitor 1A (p21/WAF1/CIP1); SDI1; SLC12A9; UV96; WAF1; Wild type p53 activated fragment 1 (WAF1); wild-type p53-activated fragment 1

Host Species:
Rabbit

Purification Method:
Ammonium sulfate precipitation, Size-exclusion - Dialysis

Regulatory Status:
RUO

Gene ID (Entrez):
1026

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Img

Thermo Scientific

PIPA514470

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Antigen:
HIPK2

Classification:
Polyclonal

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
Q9H2X6

Gene Symbols:
HIPK2

Immunogen:
KLH conjugated synthetic peptide between 437-468 amino acids from the N-terminal region of human HIPK2

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
Ig

Applications:
Immunohistochemistry (Paraffin), Western Blot

Conjugate:
Unconjugated

Gene:
HIPK2

Gene Alias:
1110014O20Rik; B230339E18Rik; cb1009; hHIPk2; HIPK2; homeodomain interacting protein kinase 2; homeodomain-interacting protein kinase 2; Nbak1; Nuclear body-associated kinase 1; PRO0593; si:dkey-16j24.2; si:dkey-239k7.1; Sialophorin tail-associated nuclear serine/threonine-protein kinase; Stank; wu:fk56d12

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography, Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
28996

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Img

Thermo Scientific

PIPA514481

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Antigen:
PCTAIRE2

Classification:
Polyclonal

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
Q00537

Gene Symbols:
CDK17

Immunogen:
KLH conjugated synthetic peptide between 47-77 amino acids from the N-terminal region of human PCTAIRE2 (PCTK2)

Quantity:
400 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
Ig

Applications:
Immunohistochemistry (Paraffin), Western Blot

Conjugate:
Unconjugated

Gene:
CDK17

Gene Alias:
6430598J10Rik; CDK17; Cell division protein kinase 17; cyclin dependent kinase 17; cyclin-dependent kinase 17; PCTAIRE protein kinase 2; PCTAIRE2; PCTAIRE-motif protein kinase 2; PCTK2; protein kinase cdc2-related PCTAIRE-2; serine/threonine-protein kinase PCTAIRE-2

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography, Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
5128

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid