PIPA522692

ATM Polyclonal Antibody, DyLight™ 550, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA522692-Each-of-1 In Stock ₹ 45,560.70

PIPA522692 - Each of 1

₹ 45,560.70

In Stock

Quantity

1

Base Price: ₹ 45,560.70

GST (18%): ₹ 8,200.926

Total Price: ₹ 53,761.626

Antigen

ATM

Classification

Polyclonal

Conjugate

DyLight 550

Gene

ATM

Gene Alias

AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

11920, 300711, 472, 479450

Content And Storage

4° C, store in dark

Form

Liquid

Applications

ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration

1.8 mg/mL

Formulation

50mM sodium borate with 0.05% sodium azide

Gene Accession No.

Q13315, Q62388

Gene Symbols

ATM

Immunogen

A fragment of human ATM protein expressed in E.coli. The fragment relates to the C-terminal region (within the last third of the protein sequence).

Quantity

50 μL

Primary or Secondary

Primary

Target Species

Canine, Human, Marsupial, Mouse, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family
  • Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer
  • The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily
  • ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1
  • The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens
  • The ATM’s C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases)
  • Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation
  • AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction
  • Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair
  • Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIPA522692

--


Antigen:
ATM

Classification:
Polyclonal

Conjugate:
DyLight 550

Gene:
ATM

Gene Alias:
AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
11920, 300711, 472, 479450

Content And Storage:
4° C, store in dark

Form:
Liquid

Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1.8 mg/mL

Formulation:
50mM sodium borate with 0.05% sodium azide

Gene Accession No.:
Q13315, Q62388

Gene Symbols:
ATM

Immunogen:
A fragment of human ATM protein expressed in E.coli. The fragment relates to the C-terminal region (within the last third of the protein sequence).

Quantity:
50 μL

Primary or Secondary:
Primary

Target Species:
Canine, Human, Marsupial, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA522693

--


Antigen:
HIF-2 alpha

Classification:
Polyclonal

Conjugate:
Biotin

Gene:
EPAS1

Gene Alias:
basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain protein 1; endothelial PAS domain protein 1b; endothelial PAS domain-containing protein 1; endothelial PAS domain-containing protein 1b; EPAS; Epas1; EPAS-1; epas1b; Hif like protein; HIF1 alpha-like factor; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF1alpha-like factor; HIF2 alpha; HIF-2 alpha; HIF2A; hif-2a; hif-2ab; HIF-2alpha; HIF-2-alpha; HIF2-alpha; HIF-related factor; HLF; HLF (HIF1alpha-like factor); HRF; hypoxia inducible factor 2 alpha; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha; Member of PAS protein 2; mHLF; MOP2; PAS domain-containing protein 2; PASD2; wu:fq36f01

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
100348809, 100771160, 13819, 2034, 29452, 443286

Content And Storage:
4° C, store in dark

Form:
Liquid

Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot

Concentration:
2 mg/mL

Formulation:
PBS with no preservative

Gene Accession No.:
P97481, Q99814, Q9JHS1

Gene Symbols:
EPAS1

Immunogen:
A peptide derived from the C-terminus of mouse/human HIF-2 alpha protein.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Fish, Hamster, Human, Mouse, Non-human Primate, Ovine, Rabbit, Rat, Reptile

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA522694

--


Antigen:
HIF-2 alpha

Classification:
Polyclonal

Conjugate:
DyLight 650

Gene:
EPAS1

Gene Alias:
basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain protein 1; endothelial PAS domain protein 1b; endothelial PAS domain-containing protein 1; endothelial PAS domain-containing protein 1b; EPAS; Epas1; EPAS-1; epas1b; Hif like protein; HIF1 alpha-like factor; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF1alpha-like factor; HIF2 alpha; HIF-2 alpha; HIF2A; hif-2a; hif-2ab; HIF-2alpha; HIF-2-alpha; HIF2-alpha; HIF-related factor; HLF; HLF (HIF1alpha-like factor); HRF; hypoxia inducible factor 2 alpha; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha; Member of PAS protein 2; mHLF; MOP2; PAS domain-containing protein 2; PASD2; wu:fq36f01

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
100348809, 100771160, 13819, 2034, 29452, 443286

Content And Storage:
4° C, store in dark

Form:
Liquid

Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot

Concentration:
0.64 mg/mL

Formulation:
50mM sodium borate with 0.05% sodium azide

Gene Accession No.:
P97481, Q99814, Q9JHS1

Gene Symbols:
EPAS1

Immunogen:
A peptide derived from the C-terminus of mouse/human HIF-2 alpha protein.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Fish, Hamster, Human, Mouse, Non-human Primate, Ovine, Rabbit, Rat, Reptile

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA522695

--


Antigen:
HIF-2 alpha

Classification:
Polyclonal

Conjugate:
DyLight 488

Gene:
EPAS1

Gene Alias:
basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain protein 1; endothelial PAS domain protein 1b; endothelial PAS domain-containing protein 1; endothelial PAS domain-containing protein 1b; EPAS; Epas1; EPAS-1; epas1b; Hif like protein; HIF1 alpha-like factor; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF1alpha-like factor; HIF2 alpha; HIF-2 alpha; HIF2A; hif-2a; hif-2ab; HIF-2alpha; HIF-2-alpha; HIF2-alpha; HIF-related factor; HLF; HLF (HIF1alpha-like factor); HRF; hypoxia inducible factor 2 alpha; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha; Member of PAS protein 2; mHLF; MOP2; PAS domain-containing protein 2; PASD2; wu:fq36f01

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
100348809, 100771160, 13819, 2034, 29452, 443286

Content And Storage:
4° C, store in dark

Form:
Liquid

Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot

Concentration:
0.66 mg/mL

Formulation:
50mM sodium borate with 0.05% sodium azide

Gene Accession No.:
P97481, Q99814, Q9JHS1

Gene Symbols:
EPAS1

Immunogen:
A peptide derived from the C-terminus of mouse/human HIF-2 alpha protein.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Fish, Hamster, Human, Mouse, Non-human Primate, Ovine, Rabbit, Rat, Reptile

Product Type:
Antibody

Isotype:
IgG