PIPA529320
MST2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA529320-Each-of-1 | In Stock | ₹ 45,218.46 |
PIPA529320 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,218.46
GST (18%): ₹ 8,139.323
Total Price: ₹ 53,357.783
Antigen
MST2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
STK3
Gene Alias
0610042I06Rik; KB-1458E12.1; KRS1; Mammalian STE20-like protein kinase 2; mess1; MST; Mst2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase Krs-1; Ste20; STE20-like kinase MST2; STK3; wu:fc19e11; zgc:55383
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6788
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q13188
Gene Symbols
STK3
Immunogen
Recombinant fragment corresponding to a region within amino acids 229 and 491 of Human STK3
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: 293T, A431, THP-1, NCI-H929, 293T mock, 293T transfected STK3
- Predicted reactivity: Mouse (91%), Rat (93%), Xenopus laevis (86%), Chicken (94%), Rhesus Monkey (99%), Bovine (99%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways, and is known to be activated by the proapoptotic stimuli staurosporine and FAS ligand
- STK3 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation
- It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
Compare Similar Items
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Antigen: MST2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: STK3
Gene Alias: 0610042I06Rik; KB-1458E12.1; KRS1; Mammalian STE20-like protein kinase 2; mess1; MST; Mst2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase Krs-1; Ste20; STE20-like kinase MST2; STK3; wu:fc19e11; zgc:55383
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6788
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: Q13188
Gene Symbols: STK3
Immunogen: Recombinant fragment corresponding to a region within amino acids 229 and 491 of Human STK3
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
MST2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
STK3
Gene Alias:
0610042I06Rik; KB-1458E12.1; KRS1; Mammalian STE20-like protein kinase 2; mess1; MST; Mst2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase Krs-1; Ste20; STE20-like kinase MST2; STK3; wu:fc19e11; zgc:55383
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6788
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
Q13188
Gene Symbols:
STK3
Immunogen:
Recombinant fragment corresponding to a region within amino acids 229 and 491 of Human STK3
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: MEKK3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Map3k3
Gene Alias: AW548911; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; Mekk3; mitogen activated protein kinase kinase kinase 3; mitogen-activated protein kinase kinase kinase 3; mKIAA4031
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 4215
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.72 mg/mL
Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: Q99759
Gene Symbols: Map3k3
Immunogen: Recombinant fragment corresponding to a region within amino acids 210 and 488 of Human MEKK3
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
MEKK3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Map3k3
Gene Alias:
AW548911; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; Mekk3; mitogen activated protein kinase kinase kinase 3; mitogen-activated protein kinase kinase kinase 3; mKIAA4031
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4215
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.72 mg/mL
Formulation:
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
Q99759
Gene Symbols:
Map3k3
Immunogen:
Recombinant fragment corresponding to a region within amino acids 210 and 488 of Human MEKK3
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: TRIP6
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TRIP6
Gene Alias: MGC10556; MGC10558; MGC29959; MGC3837; MGC4423; OIP1; OIP-1; OPA-interacting protein 1; tcag7.1300; thyroid hormone receptor interacting protein 6; thyroid hormone receptor interactor 6; thyroid receptor-interacting protein 6; TR-interacting protein 6; Trip6; TRIP-6; TRIP6i2; Zrp1; ZRP-1; zyxin related protein 1; zyxin-related protein 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 7205
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.82 mg/mL
Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.: Q15654
Gene Symbols: TRIP6
Immunogen: Recombinant fragment corresponding to a region within amino acids 162 and 454 of Human TRIP6
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
TRIP6
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TRIP6
Gene Alias:
MGC10556; MGC10558; MGC29959; MGC3837; MGC4423; OIP1; OIP-1; OPA-interacting protein 1; tcag7.1300; thyroid hormone receptor interacting protein 6; thyroid hormone receptor interactor 6; thyroid receptor-interacting protein 6; TR-interacting protein 6; Trip6; TRIP-6; TRIP6i2; Zrp1; ZRP-1; zyxin related protein 1; zyxin-related protein 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
7205
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.82 mg/mL
Formulation:
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.:
Q15654
Gene Symbols:
TRIP6
Immunogen:
Recombinant fragment corresponding to a region within amino acids 162 and 454 of Human TRIP6
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: HK2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Hk2
Gene Alias: AI642394; DKFZp686M1669; Hexokinase; hexokinase 2; hexokinase II; hexokinase type II; Hexokinase-2; hexokinase-2 muscle; hexokinase-2, muscle; Hexokinase-B; HK II; Hk2; HKII; HXK2; muscle form hexokinase; OTTHUMP00000202738
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 100009677, 15277, 25059, 3099
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.76 mg/mL
Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.: A2PYL6, O08528, P27881, P52789
Gene Symbols: Hk2
Immunogen: Recombinant fragment corresponding to a region within amino acids 53 and 342 of Human Hexokinase II
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Equine, Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
HK2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Hk2
Gene Alias:
AI642394; DKFZp686M1669; Hexokinase; hexokinase 2; hexokinase II; hexokinase type II; Hexokinase-2; hexokinase-2 muscle; hexokinase-2, muscle; Hexokinase-B; HK II; Hk2; HKII; HXK2; muscle form hexokinase; OTTHUMP00000202738
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
100009677, 15277, 25059, 3099
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.76 mg/mL
Formulation:
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.:
A2PYL6, O08528, P27881, P52789
Gene Symbols:
Hk2
Immunogen:
Recombinant fragment corresponding to a region within amino acids 53 and 342 of Human Hexokinase II
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Equine, Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG