PIPA534402
SARM Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA534402-Each-of-1 | In Stock | ₹ 45,218.46 |
PIPA534402 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,218.46
GST (18%): ₹ 8,139.323
Total Price: ₹ 53,357.783
Antigen
SARM
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SARM1
Gene Alias
A830091I15Rik; C78606; FLJ36296; KIAA0524; MyD885; MyD88-5; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif containing 1; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; tir-1 homolog
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23098, 237868, 287545
Content And Storage
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q6PDS3, Q6SZW1
Gene Symbols
SARM1
Immunogen
A 16 amino acid synthetic peptide near the amino terminus of human SARM
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- A suggested positive control is Daudi cell lysate
- PA5-34402 can be used with blocking peptide PEP-1444
- NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607)
- Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823)
- Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:31439792)
- Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922)
- Can activate neuronal cell death in response to stress (PubMed:20306472)
- Regulates dendritic arborization through the MAPK4-JNK pathway
- Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262)
- [UniProt]
Compare Similar Items
Show Difference
Antigen: SARM
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SARM1
Gene Alias: A830091I15Rik; C78606; FLJ36296; KIAA0524; MyD885; MyD88-5; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif containing 1; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; tir-1 homolog
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23098, 237868, 287545
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunohistochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: Q6PDS3, Q6SZW1
Gene Symbols: SARM1
Immunogen: A 16 amino acid synthetic peptide near the amino terminus of human SARM
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SARM
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SARM1
Gene Alias:
A830091I15Rik; C78606; FLJ36296; KIAA0524; MyD885; MyD88-5; SAM domain-containing protein 2; SAMD2; SARM; SARM1; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif containing 1; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; tir-1 homolog
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23098, 237868, 287545
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunohistochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
Q6PDS3, Q6SZW1
Gene Symbols:
SARM1
Immunogen:
A 16 amino acid synthetic peptide near the amino terminus of human SARM
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: DELE
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Dele1
Gene Alias: 0610009O20Rik; 2700004E22Rik; DAP3-binding cell death enhancer 1; Death ligand signal enhancer; Dele; Dele1; KIAA0141; RIKEN cDNA 0610009O20 gene
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 9812
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunohistochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: Q14154
Gene Symbols: Dele1
Immunogen: An 18 amino acid synthetic peptide near the amino terminus of human DELE
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
DELE
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Dele1
Gene Alias:
0610009O20Rik; 2700004E22Rik; DAP3-binding cell death enhancer 1; Death ligand signal enhancer; Dele; Dele1; KIAA0141; RIKEN cDNA 0610009O20 gene
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9812
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunohistochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
Q14154
Gene Symbols:
Dele1
Immunogen:
An 18 amino acid synthetic peptide near the amino terminus of human DELE
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: RAB21
Classification: Polyclonal
Conjugate: Unconjugated
Gene: RAB21
Gene Alias: 9630024B22; GTP-binding protein RAB21; KIAA0118; Rab-12; Rab21; RAB21, member RAS oncogene family; ras-related protein Rab-21
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 216344, 23011, 299799
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: Immunohistochemistry, Western Blot
Concentration: 1.5 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: P35282, Q6AXT5, Q9UL25
Gene Symbols: RAB21
Immunogen: A 19 amino acid synthetic peptide near the carboxy terminus of human RAB21
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
RAB21
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
RAB21
Gene Alias:
9630024B22; GTP-binding protein RAB21; KIAA0118; Rab-12; Rab21; RAB21, member RAS oncogene family; ras-related protein Rab-21
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
216344, 23011, 299799
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
Immunohistochemistry, Western Blot
Concentration:
1.5 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
P35282, Q6AXT5, Q9UL25
Gene Symbols:
RAB21
Immunogen:
A 19 amino acid synthetic peptide near the carboxy terminus of human RAB21
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: VAMP7
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Vamp7
Gene Alias: Sybl1; synaptobrevin-like 1; synaptobrevin-like protein 1; tetanus neurotoxin-insensitive VAMP; tetanus-insensitive VAMP; TIVAMP; Ti-VAMP; vamp; Vamp7; VAMP-7; vesicle associated membrane protein 7; vesicle-associated membrane protein 7
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20955, 6845, 85491
Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form: Liquid
Applications: ELISA, Immunohistochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: P51809, P70280, Q9JHW5
Gene Symbols: Vamp7
Immunogen: An 18 amino acid synthetic peptide near the amino terminus of human VAMP7
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
VAMP7
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Vamp7
Gene Alias:
Sybl1; synaptobrevin-like 1; synaptobrevin-like protein 1; tetanus neurotoxin-insensitive VAMP; tetanus-insensitive VAMP; TIVAMP; Ti-VAMP; vamp; Vamp7; VAMP-7; vesicle associated membrane protein 7; vesicle-associated membrane protein 7
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20955, 6845, 85491
Content And Storage:
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Form:
Liquid
Applications:
ELISA, Immunohistochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
P51809, P70280, Q9JHW5
Gene Symbols:
Vamp7
Immunogen:
An 18 amino acid synthetic peptide near the amino terminus of human VAMP7
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG