PIPA551927
tPA Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA551927-Each-of-1 | In Stock | ₹ 47,357.46 |
PIPA551927 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,357.46
GST (18%): ₹ 8,524.343
Total Price: ₹ 55,881.803
Antigen
tPA
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PLAT
Gene Alias
3.4.21.68; Alteplase; AU020998; AW212668; D8Ertd2e; PATISS; plasminogen activator, tissue; plasminogen activator, tissue type; plasminogen/activator kringle; PLAT; Reteplase; serine protease; t plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator; Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B; TPA; t-PA; t-plasminogen activator
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5327
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
P00750
Gene Symbols
PLAT
Immunogen
Recombinant protein corresponding to Human tPA
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: KYSSEFCSTP ACSEGNSDCY FGNGSAYRGT HSLTESGASC LPWNSMILIG KVYTAQNPSA QALGLGKHNY CRNPDGDAKP WCHVLKNRRL TWEYCDVPSC STCGLRQYSQ PQFRIKGGLF Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 77%
- TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen
- By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physio pathological events
- It specifically cleaves the Arg- -Val bond in plasminogen to form plasmin, and is comprised of a heterodimer of chain A and chain B held by a disulfide bond
- TPA binds to fibrin with high affinity
- This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-and 1000-fold, due to an increase in affinity for plasminogen
- Similarly, binding to heparin increases the activation of plasminogen
- Binding to laminin and fibronectin has also been demonstrated
- TPA also binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1)
- These proteins are involved in TPA clearance
- TPA binds to annexin II and to cytokeratin 8
- As yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation
- In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold.
Compare Similar Items
Show Difference
Antigen: tPA
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PLAT
Gene Alias: 3.4.21.68; Alteplase; AU020998; AW212668; D8Ertd2e; PATISS; plasminogen activator, tissue; plasminogen activator, tissue type; plasminogen/activator kringle; PLAT; Reteplase; serine protease; t plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator; Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B; TPA; t-PA; t-plasminogen activator
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5327
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry
Concentration: 0.1 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: P00750
Gene Symbols: PLAT
Immunogen: Recombinant protein corresponding to Human tPA
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
tPA
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PLAT
Gene Alias:
3.4.21.68; Alteplase; AU020998; AW212668; D8Ertd2e; PATISS; plasminogen activator, tissue; plasminogen activator, tissue type; plasminogen/activator kringle; PLAT; Reteplase; serine protease; t plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator; Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B; TPA; t-PA; t-plasminogen activator
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5327
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry
Concentration:
0.1 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
P00750
Gene Symbols:
PLAT
Immunogen:
Recombinant protein corresponding to Human tPA
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: MSL2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MSL2
Gene Alias: E130103E02Rik; E3 ubiquitin-protein ligase MSL2; E3 ubiquitin-protein transferase MSL2; Kiaa1585; male-specific lethal 2 homolog; male-specific lethal 2 homolog (Drosophila); male-specific lethal 2-like 1; Male-specific lethal-2 homolog; Male-specific lethal-2 homolog 1; MSL2; MSL-2; Msl2l1; MSL2-like 1; RGD1310355; ring finger protein 184; Rnf184
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 55167
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 0.3 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q9HCI7
Gene Symbols: MSL2
Immunogen: Recombinant protein corresponding to Human MSL2
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
MSL2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MSL2
Gene Alias:
E130103E02Rik; E3 ubiquitin-protein ligase MSL2; E3 ubiquitin-protein transferase MSL2; Kiaa1585; male-specific lethal 2 homolog; male-specific lethal 2 homolog (Drosophila); male-specific lethal 2-like 1; Male-specific lethal-2 homolog; Male-specific lethal-2 homolog 1; MSL2; MSL-2; Msl2l1; MSL2-like 1; RGD1310355; ring finger protein 184; Rnf184
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
55167
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
0.3 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q9HCI7
Gene Symbols:
MSL2
Immunogen:
Recombinant protein corresponding to Human MSL2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: PITPNM2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PITPNM2
Gene Alias: KIAA1457; Membrane-associated phosphatidylinositol transfer protein 2; NIR3; NIR-3; phosphatidylinositol transfer protein membrane associated 2; phosphatidylinositol transfer protein, membrane associated 2; phosphatidylinositol transfer protein, membrane-associated 2; PITPnm 2; PITPNM2; Pyk2 N-terminal domain-interacting receptor 3; RDGB2; RDGBA2; retinal degeneration B alpha 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 57605
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry
Concentration: 0.3 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q9BZ72
Gene Symbols: PITPNM2
Immunogen: Recombinant protein corresponding to Human PITPNM2
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
PITPNM2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PITPNM2
Gene Alias:
KIAA1457; Membrane-associated phosphatidylinositol transfer protein 2; NIR3; NIR-3; phosphatidylinositol transfer protein membrane associated 2; phosphatidylinositol transfer protein, membrane associated 2; phosphatidylinositol transfer protein, membrane-associated 2; PITPnm 2; PITPNM2; Pyk2 N-terminal domain-interacting receptor 3; RDGB2; RDGBA2; retinal degeneration B alpha 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
57605
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry
Concentration:
0.3 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q9BZ72
Gene Symbols:
PITPNM2
Immunogen:
Recombinant protein corresponding to Human PITPNM2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: ZNF540
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ZNF540
Gene Alias: CTD-3064H18.6; Nbla10512; putative protein product of Nbla10512; zinc finger protein 540; ZNF540
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 163255
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry
Concentration: 0.1 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q8NDQ6
Gene Symbols: ZNF540
Immunogen: Recombinant protein corresponding to Human ZNF540
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
ZNF540
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ZNF540
Gene Alias:
CTD-3064H18.6; Nbla10512; putative protein product of Nbla10512; zinc finger protein 540; ZNF540
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
163255
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry
Concentration:
0.1 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q8NDQ6
Gene Symbols:
ZNF540
Immunogen:
Recombinant protein corresponding to Human ZNF540
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG