PIPA553295

MST1 (STK4) Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA553295-Each-of-1 In Stock ₹ 50,052.60

PIPA553295 - Each of 1

₹ 50,052.60

In Stock

Quantity

1

Base Price: ₹ 50,052.60

GST (18%): ₹ 9,009.468

Total Price: ₹ 59,062.068

Antigen

MST1 (STK4)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

Stk4

Gene Alias

AI447339; AU020804; EC 2.7.11.1; Kas-2; kinase MST1; kinase responsive to stress 2; KRS2; Mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; MST1; MST-1; MST1/C; MST1/N; serine/threonine kinase 4; serine/threonine-protein kinase 4; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4 37kDa subunit; Serine/threonine-protein kinase Krs-2; STE20-like kinase MST1; sterile 20-like kinase 1; STK4; TIIAC; Yeast Sps1/Ste20-related kinase 3; Ysk3

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

311622, 58231, 6789

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry, Western Blot

Concentration

0.1 mg/mL

Formulation

PBS with 40% glycerol and 0.02% sodium azide; pH 7.2

Gene Accession No.

Q13043, Q9JI11

Gene Symbols

Stk4

Immunogen

Recombinant protein corresponding to Human MST1

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • Immunogen sequence: IEHDDTLPSQ LGTMVINAED EEEEGTMKRR DETMQPAKPS FLEYFEQKEK ENQINSFGKS VPGPLKNSSD WKIPQDGDYE F Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%
  • STK4 (MST1) is a serine/threonine kinase which may be involved in apoptosis
  • It is possible that this protein induces the chromatin condensation observed in this process
  • STK4 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation
  • It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
  • The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
  • Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
  • STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.

Compare Similar Items

Show Difference

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Thermo Scientific

PIPA553295

--


Antigen:
MST1 (STK4)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Stk4

Gene Alias:
AI447339; AU020804; EC 2.7.11.1; Kas-2; kinase MST1; kinase responsive to stress 2; KRS2; Mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; MST1; MST-1; MST1/C; MST1/N; serine/threonine kinase 4; serine/threonine-protein kinase 4; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4 37kDa subunit; Serine/threonine-protein kinase Krs-2; STE20-like kinase MST1; sterile 20-like kinase 1; STK4; TIIAC; Yeast Sps1/Ste20-related kinase 3; Ysk3

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
311622, 58231, 6789

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot

Concentration:
0.1 mg/mL

Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2

Gene Accession No.:
Q13043, Q9JI11

Gene Symbols:
Stk4

Immunogen:
Recombinant protein corresponding to Human MST1

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

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PIPA553296

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Antigen:
Aquaporin 6

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
AQP6

Gene Alias:
AI790337; AQP2L; Aqp6; AQP-6; aquaporin 2-like, kidney specific; aquaporin 6; aquaporin 6, kidney specific; Aquaporin-2-like; Aquaporin-6; aquaporin-6, kidney specific; hKID; KID; Kidney-specific aquaporin

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
363

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunohistochemistry

Concentration:
0.2 mg/mL

Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2

Gene Accession No.:
Q13520

Gene Symbols:
AQP6

Immunogen:
Recombinant protein corresponding to Human Aquaporin 6

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

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PIPA553297

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Antigen:
TULP3

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
TULP3

Gene Alias:
2310022L06Rik; AI316887; TUB like protein 3; tubby like protein 3; tubby-like protein 3; Tubby-related protein 3; TUBL3; Tulp3

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
7289

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunohistochemistry, Western Blot

Concentration:
0.05 mg/mL

Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2

Gene Accession No.:
O75386

Gene Symbols:
TULP3

Immunogen:
Recombinant protein corresponding to Human TULP3

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

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PIPA553302

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Antigen:
ZBTB11

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
ZBTB11

Gene Alias:
9230110G02Rik; ZBTB11; zinc finger and BTB domain containing 11; zinc finger and BTB domain-containing protein 11; ZNF913; ZNF-U69274

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
27107

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot

Concentration:
0.1 mg/mL

Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2

Gene Accession No.:
O95625

Gene Symbols:
ZBTB11

Immunogen:
Recombinant protein corresponding to Human ZBTB11

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG