PIPA564657

Phospho-Bora (Ser497) Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA564657-Each-of-1 In Stock ₹ 44,277.30

PIPA564657 - Each of 1

₹ 44,277.30

In Stock

Quantity

1

Base Price: ₹ 44,277.30

GST (18%): ₹ 7,969.914

Total Price: ₹ 52,247.214

Antigen

Phospho-Bora (Ser497)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

BORA

Gene Alias

6720463M24Rik; AI317232; aurora borealis; BORA; bora, aurora kinase A activator; C13orf34; HsBora; Protein aurora borealis; RGD1309522; RP11-342J4.2

Host Species

Rabbit

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

306102, 79866

Content And Storage

-20°C

Form

Liquid

Applications

Western Blot

Concentration

1 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.

Q5M864, Q6PGQ7

Gene Symbols

BORA

Immunogen

A synthesized peptide derived from human BORA (Phospho-Ser497)

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • Phospho-Bora (Ser497) Polyclonal Antibody detects endogenous levels of Bora only when phosphorylated at Ser497
  • Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis
  • Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner
  • Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1
  • PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1
  • Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry
  • Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked
  • Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation
  • At least three isoforms of Bora are known to exist.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIPA564657

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Antigen:
Phospho-Bora (Ser497)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
BORA

Gene Alias:
6720463M24Rik; AI317232; aurora borealis; BORA; bora, aurora kinase A activator; C13orf34; HsBora; Protein aurora borealis; RGD1309522; RP11-342J4.2

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
306102, 79866

Content And Storage:
-20°C

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
Q5M864, Q6PGQ7

Gene Symbols:
BORA

Immunogen:
A synthesized peptide derived from human BORA (Phospho-Ser497)

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA564658

--


Antigen:
Phospho-Calpain 2 (Ser50)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
CAPN2

Gene Alias:
80 kDa M-calpain subunit; AI326419; Calcium-activated neutral proteinase 2; calcium-dependent protease; CALP80; calpain 2; calpain 2, (m/II) large subunit; calpain 2, large [catalytic] subunit; calpain 2, large subunit; calpain II; calpain large polypeptide L2; Calpain M-type; calpain, large polypeptide L2; calpain-2 catalytic subunit; Calpain-2 large subunit; CANP 2; CANP2; CANPL2; CANPml; Capa2; Capa-2; CAPN2; cysteine proteinase; m-calpain; m-calpain 80 kDa large subunit; m-calpain large subunit; m-calpin; mCANP; millimolar-calpain

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
824

Content And Storage:
-20°C

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P17655

Gene Symbols:
CAPN2

Immunogen:
A synthesized peptide derived from human Calpain 2 (Phospho-Ser50)

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA564659

--


Antigen:
Phospho-CdGAP (Thr789)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
ARHGAP31

Gene Alias:
5830477L08Rik; AOS1; ARHGAP31; AU041750; Cdc42 GTPase-activating protein; CDGAP; D330026I07Rik; KIAA1204; Rho GTPase activating protein 31; rho GTPase-activating protein 31

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
12549, 288093, 57514

Content And Storage:
-20°C

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
A6X8Z5, Q2M1Z3

Gene Symbols:
ARHGAP31

Immunogen:
A synthesized peptide derived from human CdGAP (Phospho-Thr789)

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA564660

--


Antigen:
Phospho-CDX2 (Ser283)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
CDX2

Gene Alias:
caudal type homeo box 2; caudal type homeo box transcription factor 2; caudal type homeobox 2; caudal type homeobox transcription factor 2; caudal-type homeobox protein 2; CDX2; Cdx-2; CDX2/AS; CDX3; CDX-3; HGNC:1806; homeobox protein CDX-2; homeobox protein miniCDX2; homeobox transcription factor

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
1045, 12591, 66019

Content And Storage:
-20°C

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P43241, Q99626

Gene Symbols:
CDX2

Immunogen:
A synthesized peptide derived from human CDX2 (Phospho-Ser283)

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG