PIPA565726
VPRBP Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA565726-Each-of-1 | In Stock | ₹ 47,528.58 |
PIPA565726 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,528.58
GST (18%): ₹ 8,555.144
Total Price: ₹ 56,083.724
Antigen
VPRBP
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DCAF1
Gene Alias
AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
9730
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry
Concentration
0.2 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q9Y4B6
Gene Symbols
DCAF1
Immunogen
Recombinant Human VPRBP
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: SAKQGDRENFR KAKQKLGFSS SDPDRMFVEL SNSSWSEMSP WVIGTNYTLY PMTPAIEQRL ILQYLTPLGE YQELLPIFMQ LGSRELMMFY IDLKQTNDVL L Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%
- Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification
- Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2
- Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex
- The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination
- Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition
- Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription
- H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors
- Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2
- In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase
- The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT
- In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.
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Antigen: VPRBP
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DCAF1
Gene Alias: AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 9730
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry
Concentration: 0.2 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q9Y4B6
Gene Symbols: DCAF1
Immunogen: Recombinant Human VPRBP
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
VPRBP
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DCAF1
Gene Alias:
AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9730
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry
Concentration:
0.2 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q9Y4B6
Gene Symbols:
DCAF1
Immunogen:
Recombinant Human VPRBP
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: TMEM81
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TMEM81
Gene Alias: HC3107; KVLA2788; TMEM81; Transmembrane protein 81; UNQ2788; UNQ2788/PRO7178
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 388730
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 0.2 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q6P7N7
Gene Symbols: TMEM81
Immunogen: Recombinant Human TMEM81
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
TMEM81
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TMEM81
Gene Alias:
HC3107; KVLA2788; TMEM81; Transmembrane protein 81; UNQ2788; UNQ2788/PRO7178
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
388730
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
0.2 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q6P7N7
Gene Symbols:
TMEM81
Immunogen:
Recombinant Human TMEM81
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: UBE2V1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Ube2v1
Gene Alias: 0610011J09Rik; AI256840; CIR1; CROC1; CROC-1; CROC1B; CROC-1B; CROC-1UBE2V; D7Bwg1382e; DJ1185N5.1.3; DNA-binding protein; KUA-UEV; P/OKcl.19; TRAF6-regulated IKK activator 1 beta Uev1A; UBE2V; Ube2v1; ubiquitin conjugating enzyme E2 V1; ubiquitin conjugating enzyme E2 variant 1; ubiquitin-conjugating enzyme E2 variant 1; UEV1; UEV-1; UEV1A; UEV-1CIR1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 7335
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 0.2 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q13404
Gene Symbols: Ube2v1
Immunogen: Recombinant Human UBE2V1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
UBE2V1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Ube2v1
Gene Alias:
0610011J09Rik; AI256840; CIR1; CROC1; CROC-1; CROC1B; CROC-1B; CROC-1UBE2V; D7Bwg1382e; DJ1185N5.1.3; DNA-binding protein; KUA-UEV; P/OKcl.19; TRAF6-regulated IKK activator 1 beta Uev1A; UBE2V; Ube2v1; ubiquitin conjugating enzyme E2 V1; ubiquitin conjugating enzyme E2 variant 1; ubiquitin-conjugating enzyme E2 variant 1; UEV1; UEV-1; UEV1A; UEV-1CIR1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
7335
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
0.2 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q13404
Gene Symbols:
Ube2v1
Immunogen:
Recombinant Human UBE2V1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: SERPINB13
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SERPINB13
Gene Alias: 5430417G24; HaCaT UV-repressible serpin; headpin; HSHUR7SEQ; HUR7; HURPIN; Peptidase inhibitor 13; PI13; PI-13; protease inhibitor 13 (hurpin, headpin); proteinase inhibitor 13; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13; serpin B13; serpin family B member 13; serpin peptidase inhibitor, clade B (ovalbumin), member 13; SERPINB13; UV-B repressed sequence, HUR 7
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 5275
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry
Concentration: 0.4 mg/mL
Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.: Q9UIV8
Gene Symbols: SERPINB13
Immunogen: Recombinant Human SERPINB13
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
SERPINB13
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SERPINB13
Gene Alias:
5430417G24; HaCaT UV-repressible serpin; headpin; HSHUR7SEQ; HUR7; HURPIN; Peptidase inhibitor 13; PI13; PI-13; protease inhibitor 13 (hurpin, headpin); proteinase inhibitor 13; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13; serpin B13; serpin family B member 13; serpin peptidase inhibitor, clade B (ovalbumin), member 13; SERPINB13; UV-B repressed sequence, HUR 7
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5275
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry
Concentration:
0.4 mg/mL
Formulation:
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.:
Q9UIV8
Gene Symbols:
SERPINB13
Immunogen:
Recombinant Human SERPINB13
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG