PIPA573019
VPRBP Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA573019-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA573019 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
VPRBP
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DCAF1
Gene Alias
AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
100061218, 100343053, 100519566, 100734659, 100768333, 101097051, 315987, 321006, 415921, 9730
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Flow Cytometry, Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 0.05% BSA and 0.05% sodium azide
Gene Accession No.
Q80TR8, Q9Y4B6
Gene Symbols
DCAF1
Immunogen
A portion of amino acids 935-985 from human VPRBP was used as the immunogen.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Chicken, Equine, Feline, Guinea Pig, Hamster, Human, Marsupial, Mouse, Non-human Primate, Porcine, Rabbit, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification
- Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2
- Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex
- The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination
- Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition
- Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription
- H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors
- Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2
- In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase
- The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT
- In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.
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Antigen: VPRBP
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DCAF1
Gene Alias: AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 100061218, 100343053, 100519566, 100734659, 100768333, 101097051, 315987, 321006, 415921, 9730
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Flow Cytometry, Western Blot
Concentration: 0.5 mg/mL
Formulation: PBS with 0.05% BSA and 0.05% sodium azide
Gene Accession No.: Q80TR8, Q9Y4B6
Gene Symbols: DCAF1
Immunogen: A portion of amino acids 935-985 from human VPRBP was used as the immunogen.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Chicken, Equine, Feline, Guinea Pig, Hamster, Human, Marsupial, Mouse, Non-human Primate, Porcine, Rabbit, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
VPRBP
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DCAF1
Gene Alias:
AI447437; B930007L02Rik; DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr binding protein; HIV-1 Vpr-binding protein; KIAA0800; LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 1; MGC102804; mKIAA0800; Protein VPRBP; protein VPRBP; DDB1- and CUL4-associated factor 1; RGD1305176; RIP; Serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding protein; Vpr-binding protein; VprBP; vpr-interacting protein
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
100061218, 100343053, 100519566, 100734659, 100768333, 101097051, 315987, 321006, 415921, 9730
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Flow Cytometry, Western Blot
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.05% BSA and 0.05% sodium azide
Gene Accession No.:
Q80TR8, Q9Y4B6
Gene Symbols:
DCAF1
Immunogen:
A portion of amino acids 935-985 from human VPRBP was used as the immunogen.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Chicken, Equine, Feline, Guinea Pig, Hamster, Human, Marsupial, Mouse, Non-human Primate, Porcine, Rabbit, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: SAMHD1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SAMHD1
Gene Alias: CHBL2; DCIP; Dendritic cell-derived IFNG-induced protein; deoxynucleoside triphosphate triphosphohydrolase SAMHD1; dNTPase; E330031J07Rik; EGK_02438; HDDC1; hSAMHD1; IFN-gamma induced; interferon-gamma-inducible protein Mg11; Mg11; Mg21; Monocyte protein 5; MOP5; MOP-5; mSAMHD1; RP1-132F21.1; SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1; SAM domain and HD domain 1; SAM domain and HD domain, 1; SAM domain and HD domain-containing protein 1; Samhd1; SBBI88
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 25939, 311580, 56045
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.5 mg/mL
Formulation: PBS with 0.05% BSA and 0.05% sodium azide
Gene Accession No.: Q60710, Q9Y3Z3
Gene Symbols: SAMHD1
Immunogen: This antibody was raised against SAMHD1.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Non-human Primate, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SAMHD1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SAMHD1
Gene Alias:
CHBL2; DCIP; Dendritic cell-derived IFNG-induced protein; deoxynucleoside triphosphate triphosphohydrolase SAMHD1; dNTPase; E330031J07Rik; EGK_02438; HDDC1; hSAMHD1; IFN-gamma induced; interferon-gamma-inducible protein Mg11; Mg11; Mg21; Monocyte protein 5; MOP5; MOP-5; mSAMHD1; RP1-132F21.1; SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1; SAM domain and HD domain 1; SAM domain and HD domain, 1; SAM domain and HD domain-containing protein 1; Samhd1; SBBI88
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
25939, 311580, 56045
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.05% BSA and 0.05% sodium azide
Gene Accession No.:
Q60710, Q9Y3Z3
Gene Symbols:
SAMHD1
Immunogen:
This antibody was raised against SAMHD1.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Non-human Primate, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: HES7
Classification: Polyclonal
Conjugate: Unconjugated
Gene: HES7
Gene Alias: bHLH factor Hes7; bHLHb37; class B basic helix-loop-helix protein 37; Hairy and enhancer of split 7; hairy and enhancer of split 7 (Drosophila); hes family bHLH transcription factor 7; HES7; hHes7; mHes7; SCDO4; transcription factor HES-7
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 287423, 84653, 84667
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Western Blot
Concentration: 0.5 mg/mL
Formulation: antibody with no preservative
Gene Accession No.: Q8BKT2, Q9BYE0
Gene Symbols: HES7
Immunogen: Antibody for amino acid sequence 6-23 (RAENRDGPkMLkPLVEkRc) was used as the immunogen.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
HES7
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
HES7
Gene Alias:
bHLH factor Hes7; bHLHb37; class B basic helix-loop-helix protein 37; Hairy and enhancer of split 7; hairy and enhancer of split 7 (Drosophila); hes family bHLH transcription factor 7; HES7; hHes7; mHes7; SCDO4; transcription factor HES-7
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
287423, 84653, 84667
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Western Blot
Concentration:
0.5 mg/mL
Formulation:
antibody with no preservative
Gene Accession No.:
Q8BKT2, Q9BYE0
Gene Symbols:
HES7
Immunogen:
Antibody for amino acid sequence 6-23 (RAENRDGPkMLkPLVEkRc) was used as the immunogen.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: RDH11
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Rdh11
Gene Alias: 2610319N22Rik; AI428145; all-trans and 9-cis; androgen-regulated short-chain dehydrogenase/reductase 1; Arsdr1; AU045252; C85936; cell line MC/9.IL4 derived transcript 1; cell line MC/9.IL4-derived protein 1; CGI82; CGI-82; HCBP12; HCV core-binding protein HCBP12; M42C60; Mdt1; prostate short-chain dehydrogenase reductase 1; prostate short-chain dehydrogenase/reductase 1; Psdr1; ralR1; Rdh11; RDJCSS; Retinal reductase 1; retinol dehydrogenase 11; retinol dehydrogenase 11 (all-trans/9-cis/11-cis); SCALD; SDR7C1; Short chain dehydrogenase/reductase family 7C member 1; short chain dehydrogenase/reductase family 7C, member 1; short-chain aldehyde dehydrogenase; short-chain dehydrogenase/reductase 1; Ube-1c; UBE-1c1; ubiquitously expressing
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 51109
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.02% sodium azide
Gene Accession No.: Q8TC12
Gene Symbols: Rdh11
Immunogen: Synthetic peptides corresponding to the N terminal sequence MVELMFP and the C terminal sequence LLGLPID of the human RDH11/ PSDR1 protein
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
RDH11
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Rdh11
Gene Alias:
2610319N22Rik; AI428145; all-trans and 9-cis; androgen-regulated short-chain dehydrogenase/reductase 1; Arsdr1; AU045252; C85936; cell line MC/9.IL4 derived transcript 1; cell line MC/9.IL4-derived protein 1; CGI82; CGI-82; HCBP12; HCV core-binding protein HCBP12; M42C60; Mdt1; prostate short-chain dehydrogenase reductase 1; prostate short-chain dehydrogenase/reductase 1; Psdr1; ralR1; Rdh11; RDJCSS; Retinal reductase 1; retinol dehydrogenase 11; retinol dehydrogenase 11 (all-trans/9-cis/11-cis); SCALD; SDR7C1; Short chain dehydrogenase/reductase family 7C member 1; short chain dehydrogenase/reductase family 7C, member 1; short-chain aldehyde dehydrogenase; short-chain dehydrogenase/reductase 1; Ube-1c; UBE-1c1; ubiquitously expressing
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
51109
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.02% sodium azide
Gene Accession No.:
Q8TC12
Gene Symbols:
Rdh11
Immunogen:
Synthetic peptides corresponding to the N terminal sequence MVELMFP and the C terminal sequence LLGLPID of the human RDH11/ PSDR1 protein
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG