Phospho-Cyclin B3 (Ser277) Polyclonal Antibody, Invitrogen™

Description

• Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes
• These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase
• The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes
• The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit
• Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle, thereby regulating kinase activity
• Cyclin B3, also known as CCNB3 or CYCB3, is a 1,395 amino acid nuclear protein that belongs to the cyclin family of regulatory proteins
• Expressed in testis with lower expression in a variety of other tissues, cyclin B3 is thought to be required for early meiotic prophase I, playing an important role in the meiotic cell cycle
• Three isoforms of cyclin B3 exist due to alternative splicing events.