PIPA572982

MBD4 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 PIPA572982-Each-of-1 In Stock ₹ 44,705.10

PIPA572982 - Each of 1

₹ 44,705.10

In Stock

Quantity

1

Base Price: ₹ 44,705.10

GST (18%): ₹ 8,046.918

Total Price: ₹ 52,752.018

Antigen

MBD4

Classification

Polyclonal

Conjugate

Unconjugated

Gene

MBD4

Gene Alias

3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; Mbd4; MED1; methyl-CpG binding domain 4 DNA glycosylase; methyl-CpG binding domain 4, DNA glycosylase; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; Methyl-CpG-binding endonuclease 1; methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

8930

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration

1.11 mg/mL

Formulation

PBS with 30% glycerol and 0.05% sodium azide

Gene Accession No.

O95243

Gene Symbols

MBD4

Immunogen

A synthetic peptide made to an internal portion of the human MBD4 protein (between residues 200-250) [UniProt O95243]

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Description

  • DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression
  • The methylation pattern involves the enzymatic processes of methylation and demethylation
  • The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD)
  • The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol
  • MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA
  • MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal
  • Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro
  • MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity
  • MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases
  • In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.

Compare Similar Items

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Img

Thermo Scientific

PIPA572982

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Antigen:
MBD4

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
MBD4

Gene Alias:
3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; Mbd4; MED1; methyl-CpG binding domain 4 DNA glycosylase; methyl-CpG binding domain 4, DNA glycosylase; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; Methyl-CpG-binding endonuclease 1; methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
8930

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1.11 mg/mL

Formulation:
PBS with 30% glycerol and 0.05% sodium azide

Gene Accession No.:
O95243

Gene Symbols:
MBD4

Immunogen:
A synthetic peptide made to an internal portion of the human MBD4 protein (between residues 200-250) [UniProt O95243]

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA572984

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Antigen:
ZNF521

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
ZNF521

Gene Alias:
B930086A16Rik; early hematopoietic zinc finger protein; Ecotropic viral integration site 3 protein; EHZF; Evi3; LIP3; LYST-interacting protein 3; Zfp521; Zinc finger protein 521; Znf521

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
225207, 25925

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1.11 mg/mL

Formulation:
PBS with 30% glycerol and 0.05% sodium azide

Gene Accession No.:
Q6KAS7, Q96K83

Gene Symbols:
Zfp521, ZNF521

Immunogen:
A synthetic peptide made to an internal portion of the human ZNF521 protein (between residues 450-550) [UniProt Q96K83]

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA572986

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Antigen:
SETX

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
SETX

Gene Alias:
A130090N03; A930037J23Rik; Als4; amyotrophic lateral sclerosis 4 homolog; amyotrophic lateral sclerosis 4 protein; Amyotrophic lateral sclerosis 4 protein homolog; AOA2; AW060766; bA479K20.2; DEAxQ-box helicase; KIAA0625; mKIAA0625; Probable helicase senataxin; RGD1565575; SCAR1; Sen1; SEN1 homolog; senataxin; Setx; tRNA splicing endonuclease regulator 1

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
23064, 269254

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 30% glycerol and 0.05% sodium azide

Gene Accession No.:
A2AKX3, Q7Z333

Gene Symbols:
SETX

Immunogen:
A genomic peptide made to an internal portion of the human Senataxin protein (between residues 600-750) [UniProt Q7Z333]

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA572989

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Antigen:
PIF1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
PIF1

Gene Alias:
4631410M14; AI449441; ATP-dependent DNA helicase PIF1; ATP-dependent DNA helicase PIF1 {ECO:0000255; C15orf20; DNA helicase-like protein; DNA repair and recombination helicase PIF1; DNA repair and recombination helicase PIF1 {ECO:0000255; HAMAP-Rule:MF_03176}; petite integration frequency 1; PIF; Pif1; PIF1 5'-to-3' DNA helicase; PIF1 5'-to-3' DNA helicase homolog; PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae); PIF1 homolog; Pif1/Rrm3 DNA helicase-like protein; Pif1/Rrm3 DNA-helicase-like protein

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
208084

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1.16 mg/mL

Formulation:
PBS with 30% glycerol and 0.05% sodium azide

Gene Accession No.:
Q80SX8

Gene Symbols:
PIF1

Immunogen:
A synthetic peptide made to an internal portion of the human PIF1 protein (between residues 400-500) [UniProt Q9H611]

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Mouse

Product Type:
Antibody

Isotype:
IgG