KV1.2 (KCNA2) Polyclonal Antibody, Invitrogen™

Description

• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Kcna2 is a voltage-gated potassium channel (KV) that belongs to the 6-TM family of potassium channel and also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies
• The alpha-subunits contain a single pore-forming region and combine to form tetramers
• Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints
• The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume
• Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s)
• The Kcna2 gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily
• Kcna2 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment
• Further, Kcna2 belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential
• The coding region of the Kcna2 gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1
• Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.