PIPA586124

Chk1 Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA586124-Each-of-1 In Stock ₹ 44,705.10

PIPA586124 - Each of 1

₹ 44,705.10

In Stock

Quantity

1

Base Price: ₹ 44,705.10

GST (18%): ₹ 8,046.918

Total Price: ₹ 52,752.018

Antigen

Chk1

Classification

Polyclonal

Conjugate

Unconjugated

Gene

Chek1

Gene Alias

C85740, Cell cycle checkpoint kinase, checkpoint kinase 1, checkpoint kinase 1 homolog, checkpoint kinase-1, Checkpoint, S. pombe, homolog of, 1, CHEK1, CHK1, CHK1 checkpoint homolog, Chk1-S, homolog of Chk1-S, HRD1 Protein, rad27, rad27 homolog, serine/threonine protein kinase CHK1, serine/threonine-protein kinase Chk1, Synoviolin, YBR1742, YBR274W

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

1111, 12649, 140583

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Western Blot

Concentration

1 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.

O14757, O35280, Q91ZN7

Gene Symbols

Chek1

Immunogen

Synthetic peptide, corresponding to amino acids 251-300 of Human Chk1.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised
  • CHK1 is a key mediator in the DNA damage-induced checkpoint network
  • CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress
  • When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase
  • Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIPA586124

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Antigen:
Chk1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Chek1

Gene Alias:
C85740, Cell cycle checkpoint kinase, checkpoint kinase 1, checkpoint kinase 1 homolog, checkpoint kinase-1, Checkpoint, S. pombe, homolog of, 1, CHEK1, CHK1, CHK1 checkpoint homolog, Chk1-S, homolog of Chk1-S, HRD1 Protein, rad27, rad27 homolog, serine/threonine protein kinase CHK1, serine/threonine-protein kinase Chk1, Synoviolin, YBR1742, YBR274W

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
1111, 12649, 140583

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.:
O14757, O35280, Q91ZN7

Gene Symbols:
Chek1

Immunogen:
Synthetic peptide, corresponding to amino acids 251-300 of Human Chk1.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA586125

--


Antigen:
CHK2

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Chek2

Gene Alias:
CDS1, cds1 homolog, Checkpoint kinase 2, Checkpoint like protein CHK2, checkpoint-like protein CHK2, Chek2, Chk2, Chk2 (phospho T68), Chk2 (pThr68), CHK2 checkpoint homolog, CHK2 checkpoint homolog (S. pombe), Chk2 phospho, Chk2 phospho T68, del9, EC 2.7.11.1, hCds1, HuCds 1, HuCds1, kinase Chk2, LFS2, OTTHUMP00000199044, OTTHUMP00000199045, OTTHUMP00000199064, OTTHUMP00000199115, OTTHUMP00000199116, phospho Chk2 (T68), phospho Thr68 Chk2, PP1425, protein kinase Chk2, Rad53, Rad53 homolog, RP11-436C9.1, Serine/threonine protein kinase Chk2, serine/threonine-protein kinase Chk2

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
11200, 114212, 50883

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin)

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.:
O96017, Q9Z265

Gene Symbols:
Chek2

Immunogen:
Synthetic peptide, corresponding to amino acids 31-80 of Human Chk2.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA586126

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Antigen:
Collagen II

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Col2a1

Gene Alias:
alpha 1 type II procollagen, alpha 1 type IIA collagen, alpha 1 type IIA collagen precursor, alpha collagen type II, alpha-1 type II collagen, ANFH, AOM, arthroophthalmopathy, progressive (Stickler syndrome), cartilage collagen, CB11, CG2A1A, CGA, Chondrocalcin, COL11A3, Col2, Col2a, col2a1, Col2a-1, col2a1.L, col2a1a, col2a1-a, col2a1-b, Collagen 2, Collagen alpha-1(II) chain, collagen II, alpha-1 polypeptide, collagen type II (Col2A1) gene, enhancer region, collagen type II alpha 1 chain, collagen type IIA, collagen, type II, alpha 1, collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital), collagen, type II, alpha 1 L homeolog, COLLII, cyanogen bromide, Del1, disproportionate micromelia, Dmm, Lpk, M100856, MGC131516, pro alpha1 type II collagen, pro-alpha 1(II), pro-alpha-1 type II collagen, procollagen alpha 1(II), Procollagen II alpha 1, procollagen, type II, alpha 1, Rgsc856, SEDC, STL1, type II collagen, type II collagen cyanogen bromide fragment CB10, type II collogen cyanogen bromide fragment CB8, unnamed protein product, X-col II, xcol2a1, XELAEV_18013523mg

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
1280, 12824, 25412

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.:
P02458, P05539, P28481

Gene Symbols:
Col2a1

Immunogen:
Synthetic peptide, corresponding to amino acids 101-150 of Human COL2A1.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA586127

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Antigen:
COL4A1

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
COL4A1

Gene Alias:
alpha 1 type IV collagen, alpha1(IV) collagen, arresten, Bru, BSVD, COL4A1, Col4a-1, COL4A1 NC1 domain, collagen alpha-1(IV) chain, collagen IV, alpha-1 polypeptide, collagen of basement membrane, alpha-1 chain, collagen type IV alpha 1 chain, collagen, type IV, alpha 1, Del(8)44H, Del(8)Bru44H, procollagen, type IV, alpha 1, RATOR, Raw, retinal anterior wiring, Svc

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
1282, 12826, 290905

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2

Gene Accession No.:
P02462, P02463

Gene Symbols:
COL4A1

Immunogen:
Synthetic peptide, corresponding to amino acids 11-60 of Human COL4A1.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG