PIPA586207
SIRP alpha Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA586207-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA586207 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
SIRP alpha
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SIRPA
Gene Alias
AI835480, Bit, brain Ig-like molecule with tyrosine-based activation motifs, Brain immunoglobulin like protein with tyrosine - based activation motifs, brain immunological-like with tyrosine-based motifs, brain-immunoglobulin-like molecule with tyrosine-based activation motifs, CD172, CD172 alpha, CD172 antigen-like family member A, CD172A, Inhibitory receptor SHPS-1, macrophage fusion receptor, Macrophage membrane protein MFP150, MFR, mSIRP-alpha1, Myd1, MYD-1, myD-1 antigen, p84, Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1), protein tyrosine phosphatase, non-receptor type substrate 1, Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1), Ptpns1, SHP substrate 1, SHP-1, SHPS1, SHPS-1, signal regulatory protein alpha, signal-regulatory protein alpha, signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, SIRP, Sirpa, SIRPalpha, Sirp-alpha-1, SIRPalpha2, Sirp-alpha-2, Sirp-alpha-3,
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
140885, 19261, 25528
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide, pH 7.2
Gene Accession No.
P78324, P97710, P97797
Gene Symbols
SIRPA
Immunogen
Synthetic peptide, corresponding to amino acids 320-370 of Human SHP-2.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and hematopoietic stem cells
- SIRP alpha acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways
- The ligand binding of SIRP alpha to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of SIRP alpha, which mediates the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2
- Ligation of SIRP alpha with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs
- SIRP alpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion, and plays a general role in different physiological and pathological processes
- Cancer cells highly express CD47, which activates SIRP alpha and inhibits macrophage-mediated destruction of cancerous cell growth.
Compare Similar Items
Show Difference
Antigen: SIRP alpha
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SIRPA
Gene Alias: AI835480, Bit, brain Ig-like molecule with tyrosine-based activation motifs, Brain immunoglobulin like protein with tyrosine - based activation motifs, brain immunological-like with tyrosine-based motifs, brain-immunoglobulin-like molecule with tyrosine-based activation motifs, CD172, CD172 alpha, CD172 antigen-like family member A, CD172A, Inhibitory receptor SHPS-1, macrophage fusion receptor, Macrophage membrane protein MFP150, MFR, mSIRP-alpha1, Myd1, MYD-1, myD-1 antigen, p84, Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1), protein tyrosine phosphatase, non-receptor type substrate 1, Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1), Ptpns1, SHP substrate 1, SHP-1, SHPS1, SHPS-1, signal regulatory protein alpha, signal-regulatory protein alpha, signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, SIRP, Sirpa, SIRPalpha, Sirp-alpha-1, SIRPalpha2, Sirp-alpha-2, Sirp-alpha-3,
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 140885, 19261, 25528
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.05% sodium azide, pH 7.2
Gene Accession No.: P78324, P97710, P97797
Gene Symbols: SIRPA
Immunogen: Synthetic peptide, corresponding to amino acids 320-370 of Human SHP-2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SIRP alpha
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SIRPA
Gene Alias:
AI835480, Bit, brain Ig-like molecule with tyrosine-based activation motifs, Brain immunoglobulin like protein with tyrosine - based activation motifs, brain immunological-like with tyrosine-based motifs, brain-immunoglobulin-like molecule with tyrosine-based activation motifs, CD172, CD172 alpha, CD172 antigen-like family member A, CD172A, Inhibitory receptor SHPS-1, macrophage fusion receptor, Macrophage membrane protein MFP150, MFR, mSIRP-alpha1, Myd1, MYD-1, myD-1 antigen, p84, Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1), protein tyrosine phosphatase, non-receptor type substrate 1, Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1), Ptpns1, SHP substrate 1, SHP-1, SHPS1, SHPS-1, signal regulatory protein alpha, signal-regulatory protein alpha, signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, SIRP, Sirpa, SIRPalpha, Sirp-alpha-1, SIRPalpha2, Sirp-alpha-2, Sirp-alpha-3,
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
140885, 19261, 25528
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.05% sodium azide, pH 7.2
Gene Accession No.:
P78324, P97710, P97797
Gene Symbols:
SIRPA
Immunogen:
Synthetic peptide, corresponding to amino acids 320-370 of Human SHP-2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: STAT3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: STAT3
Gene Alias: 1110034C02Rik, acute phase response factor, acute-phase response factor, ADMIO, ADMIO1, APRF, AW109958, DNA-binding protein APRF, FLJ20882, HIES, MGC16063, signal transducer and activator of transcription 3, signal transducer and activator of transcription 3 (acute-phase response factor), signal transducer, activator of transcription, acute-phase response factor, signal transduction and activation of transcription 3, STAT, STAT3, STAT-3, stat3 protein, STAT3b1, STAT3b2, transcription factor, Unknown (protein for MGC:128731), wu:fc15d02, wu:fl59g06, z-Stat3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20848, 25125, 6774
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P40763, P42227, P52631
Gene Symbols: STAT3
Immunogen: Synthetic peptide, corresponding to amino acids 700-750 of Human Stat3.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
STAT3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
STAT3
Gene Alias:
1110034C02Rik, acute phase response factor, acute-phase response factor, ADMIO, ADMIO1, APRF, AW109958, DNA-binding protein APRF, FLJ20882, HIES, MGC16063, signal transducer and activator of transcription 3, signal transducer and activator of transcription 3 (acute-phase response factor), signal transducer, activator of transcription, acute-phase response factor, signal transduction and activation of transcription 3, STAT, STAT3, STAT-3, stat3 protein, STAT3b1, STAT3b2, transcription factor, Unknown (protein for MGC:128731), wu:fc15d02, wu:fl59g06, z-Stat3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20848, 25125, 6774
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P40763, P42227, P52631
Gene Symbols:
STAT3
Immunogen:
Synthetic peptide, corresponding to amino acids 700-750 of Human Stat3.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: STAT6
Classification: Polyclonal
Conjugate: Unconjugated
Gene: STAT6
Gene Alias: 12S1644, D12S1644, IL4 STAT, IL-4 Stat, IL-4-STAT, signal transducer and activator of transcription 6, signal transducer and activator of transcription 6, interleukin-4 induced, signal transducer and transcription activator 6, STAT, STAT, interleukin4-induced, Stat6, STAT-6, STAT6B, STAT6C, transcription factor IL-4 STAT
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20852, 362896, 6778
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P42226, P52633
Gene Symbols: STAT6
Immunogen: Synthetic peptide, corresponding to amino acids 610-660 of Human Stat6.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
STAT6
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
STAT6
Gene Alias:
12S1644, D12S1644, IL4 STAT, IL-4 Stat, IL-4-STAT, signal transducer and activator of transcription 6, signal transducer and activator of transcription 6, interleukin-4 induced, signal transducer and transcription activator 6, STAT, STAT, interleukin4-induced, Stat6, STAT-6, STAT6B, STAT6C, transcription factor IL-4 STAT
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20852, 362896, 6778
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P42226, P52633
Gene Symbols:
STAT6
Immunogen:
Synthetic peptide, corresponding to amino acids 610-660 of Human Stat6.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Cystatin B
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CSTB
Gene Alias: AA960480, CPI-B, Cst6, CSTB, Cyb, cystatin B, cystatin B (stefin B), cystatin B protein, cystatin beta, cystatin-B, Cystatin-beta, Epm1, EPM1A, Liver thiol proteinase inhibitor, LOC101123010, PME, stefin B, Stefin-B, stefin-C, Stfb, ULD, Unknown (protein for MGC:134609)
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 13014, 1476, 25308
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P01041, P04080, Q62426
Gene Symbols: CSTB
Immunogen: Synthetic peptide, corresponding to amino acids 51-100 of Human Cystatin B.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Cystatin B
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CSTB
Gene Alias:
AA960480, CPI-B, Cst6, CSTB, Cyb, cystatin B, cystatin B (stefin B), cystatin B protein, cystatin beta, cystatin-B, Cystatin-beta, Epm1, EPM1A, Liver thiol proteinase inhibitor, LOC101123010, PME, stefin B, Stefin-B, stefin-C, Stfb, ULD, Unknown (protein for MGC:134609)
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13014, 1476, 25308
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P01041, P04080, Q62426
Gene Symbols:
CSTB
Immunogen:
Synthetic peptide, corresponding to amino acids 51-100 of Human Cystatin B.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG