PIPA587438
MCL-1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA587438-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA587438 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
MCL-1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MCL1
Gene Alias
AW556805, BCL2 family apoptosis regulator, BCL2L3, bcl2-L-3, Bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Mcl1, Mcl-1, mcl1/EAT, MCL1-ES, MCL1L, MCL1S, MCL-1S, MGC104264, MGC1839, myeloid cell leukemia 1, myeloid cell leukemia ES, myeloid cell leukemia sequence 1, myeloid cell leukemia sequence 1 (BCL2-related), TM
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17210, 60430
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot, Western Blot
Concentration
0.71 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
P97287, Q9Z1P3
Gene Symbols
MCL1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human MCL1 (NP_0687791)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse, Rat, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Jurkat, K-562, MCF-7, DU145; Cellular Location: Cytoplasm, Membrane, Mitochondrion, Nucleus, Single-pass membrane protein, nucleoplasm Immunogen sequence: MFGLKRNAVI GLNLYCGGAG LGAGSGGATR PGGRLLATEK EASARREIGG GEAGAVIGGS AGASPPSTLT PDSRRVARPP PIGAEVPDVT ATPARLLFFA PTRRAAPLEE MEAPAADAIM SPEEELDGYE PEPLGKRPAV LPLLELVGES GNNTSTDGSL PSTPPPAEEE EDELYRQSLE IISRYLREQA TGAKDTKPMG RSGATSRKAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE DDVKSLSRVM IHVFSDGVTN WGRIVTLISF GAFVAKHLKT INQESCIEPL AESITDVLVR TKRDWLVKQR GWDGFVEFFH VEDLEGG MCL1 (Myeloid cell leukemia-1) belongs to the Bcl-2 family and is involved in programing, differentiation and concomitant maintenance of cell viability, but not of proliferation
- Isoform 1 of MCL1 inhibits apoptosis while isoform 2 promotes it
- The carboxy terminal of MCL1 and bcl-2 share significant sequence homology
- Expression of MCL1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g
- ionizing radiation, μgtraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2
- Enhanced expression of MCL1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation
- Like bcl-2, MCL1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis
- While the mechanism by which MCL1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak
- MCL1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types
- MCL1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals
- MCL1 exists as at least two distinct isoforms designated MCL1L and MCL1S
- In marked contrast to the larger isoform of MCL1, overexpression of MCL1S promotes cell death.
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Antigen: MCL-1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MCL1
Gene Alias: AW556805, BCL2 family apoptosis regulator, BCL2L3, bcl2-L-3, Bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Mcl1, Mcl-1, mcl1/EAT, MCL1-ES, MCL1L, MCL1S, MCL-1S, MGC104264, MGC1839, myeloid cell leukemia 1, myeloid cell leukemia ES, myeloid cell leukemia sequence 1, myeloid cell leukemia sequence 1 (BCL2-related), TM
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17210, 60430
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Western Blot, Western Blot
Concentration: 0.71 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: P97287, Q9Z1P3
Gene Symbols: MCL1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human MCL1 (NP_0687791)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Mouse, Rat, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MCL-1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MCL1
Gene Alias:
AW556805, BCL2 family apoptosis regulator, BCL2L3, bcl2-L-3, Bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Mcl1, Mcl-1, mcl1/EAT, MCL1-ES, MCL1L, MCL1S, MCL-1S, MGC104264, MGC1839, myeloid cell leukemia 1, myeloid cell leukemia ES, myeloid cell leukemia sequence 1, myeloid cell leukemia sequence 1 (BCL2-related), TM
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17210, 60430
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot, Western Blot
Concentration:
0.71 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P97287, Q9Z1P3
Gene Symbols:
MCL1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human MCL1 (NP_0687791)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Mouse, Rat, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: XRCC1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: XRCC1
Gene Alias: DNA repair protein XRCC1, RCC, X-ray repair complementing defective repair in Chinese hamster cells 1, X-ray repair cross complementing 1, x-ray repair cross-complementing group 1 protein, X-ray repair cross-complementing protein 1, XRCC1, Xrcc-1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 22594, 7515, 84495
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.58 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: P18887, Q60596, Q9ESZ0
Gene Symbols: XRCC1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 480-633 of human XRCC1 (NP_0062882)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
XRCC1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
XRCC1
Gene Alias:
DNA repair protein XRCC1, RCC, X-ray repair complementing defective repair in Chinese hamster cells 1, X-ray repair cross complementing 1, x-ray repair cross-complementing group 1 protein, X-ray repair cross-complementing protein 1, XRCC1, Xrcc-1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22594, 7515, 84495
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.58 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P18887, Q60596, Q9ESZ0
Gene Symbols:
XRCC1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 480-633 of human XRCC1 (NP_0062882)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: eIF4E
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Eif4e
Gene Alias: AUTS19, CBP, EG668879, EIF4E, EIF-4E, EIF4E1, EIF4EL1, Eif4e-ps, EIF4F, eIF-4F 25 kDa subunit, eukaryotic translation initiation factor 4E, eukaryotic translation initiation factor 4E-like 1, eukaryotic translation initiation factor 4E-like protein, eukaryotic translation initiation factor 4-like protein, If4e, MGC111573, mRNA cap-binding protein, OTTHUMP00000219703, OTTHUMP00000219704, OTTHUMP00000219705, translation initiation factor eIF-4E
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1977
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 0.09 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P06730
Gene Symbols: Eif4e
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human eIF4E (NP_0019591)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
eIF4E
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Eif4e
Gene Alias:
AUTS19, CBP, EG668879, EIF4E, EIF-4E, EIF4E1, EIF4EL1, Eif4e-ps, EIF4F, eIF-4F 25 kDa subunit, eukaryotic translation initiation factor 4E, eukaryotic translation initiation factor 4E-like 1, eukaryotic translation initiation factor 4E-like protein, eukaryotic translation initiation factor 4-like protein, If4e, MGC111573, mRNA cap-binding protein, OTTHUMP00000219703, OTTHUMP00000219704, OTTHUMP00000219705, translation initiation factor eIF-4E
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1977
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
0.09 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P06730
Gene Symbols:
Eif4e
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human eIF4E (NP_0019591)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: PKC delta
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PRKCD
Gene Alias: 1-May, AI385711, ALPS3, CVID9, D14Ertd420e, kinase nPKC-delta, KPCD, MAY1, nPKC-delta, PKC[d], Pkcd, PKCdelta, Prkcd, protein kinase C delta, protein kinase C delta type, Protein kinase C delta type catalytic subunit, Protein kinase C delta type regulatory subunit, protein kinase C delta variant IX, protein kinase C delta VIII, protein kinase C, delta, protein kinase C, delta IV, protein kinase C, delta V, protein kinase C[d], SDK1, Sphingosine-dependent protein kinase-1, Tyrosine-protein kinase PRKCD
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 170538, 18753, 5580
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.12 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: P09215, P28867, Q05655
Gene Symbols: PRKCD
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PKC delta (NP_0062452)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
PKC delta
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PRKCD
Gene Alias:
1-May, AI385711, ALPS3, CVID9, D14Ertd420e, kinase nPKC-delta, KPCD, MAY1, nPKC-delta, PKC[d], Pkcd, PKCdelta, Prkcd, protein kinase C delta, protein kinase C delta type, Protein kinase C delta type catalytic subunit, Protein kinase C delta type regulatory subunit, protein kinase C delta variant IX, protein kinase C delta VIII, protein kinase C, delta, protein kinase C, delta IV, protein kinase C, delta V, protein kinase C[d], SDK1, Sphingosine-dependent protein kinase-1, Tyrosine-protein kinase PRKCD
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
170538, 18753, 5580
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.12 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P09215, P28867, Q05655
Gene Symbols:
PRKCD
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PKC delta (NP_0062452)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG