PIPA586174
MCL-1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA586174-Each-of-1 | In Stock | ₹ 44,277.30 |
PIPA586174 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,277.30
GST (18%): ₹ 7,969.914
Total Price: ₹ 52,247.214
Antigen
MCL-1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MCL1
Gene Alias
AW556805, BCL2 family apoptosis regulator, BCL2L3, bcl2-L-3, Bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Mcl1, Mcl-1, mcl1/EAT, MCL1-ES, MCL1L, MCL1S, MCL-1S, MGC104264, MGC1839, myeloid cell leukemia 1, myeloid cell leukemia ES, myeloid cell leukemia sequence 1, myeloid cell leukemia sequence 1 (BCL2-related), TM
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17210, 4170, 60430
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.
P97287, Q07820, Q9Z1P3
Gene Symbols
MCL1
Immunogen
Synthetic peptide, corresponding to amino acids 100-150 of Human Mcl-1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Description MCL1 (Myeloid cell leukemia-1) belongs to the Bcl-2 family and is involved in programing, differentiation and concomitant maintenance of cell viability, but not of proliferation
- Isoform 1 of MCL1 inhibits apoptosis while isoform 2 promotes it
- The carboxy terminal of MCL1 and bcl-2 share significant sequence homology
- Expression of MCL1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g
- ionizing radiation, μgtraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2
- Enhanced expression of MCL1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation
- Like bcl-2, MCL1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis
- While the mechanism by which MCL1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak
- MCL1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types
- MCL1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals
- MCL1 exists as at least two distinct isoforms designated MCL1L and MCL1S
- In marked contrast to the larger isoform of MCL1, overexpression of MCL1S promotes cell death.
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Antigen: MCL-1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MCL1
Gene Alias: AW556805, BCL2 family apoptosis regulator, BCL2L3, bcl2-L-3, Bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Mcl1, Mcl-1, mcl1/EAT, MCL1-ES, MCL1L, MCL1S, MCL-1S, MGC104264, MGC1839, myeloid cell leukemia 1, myeloid cell leukemia ES, myeloid cell leukemia sequence 1, myeloid cell leukemia sequence 1 (BCL2-related), TM
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17210, 4170, 60430
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P97287, Q07820, Q9Z1P3
Gene Symbols: MCL1
Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Mcl-1.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MCL-1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MCL1
Gene Alias:
AW556805, BCL2 family apoptosis regulator, BCL2L3, bcl2-L-3, Bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Mcl1, Mcl-1, mcl1/EAT, MCL1-ES, MCL1L, MCL1S, MCL-1S, MGC104264, MGC1839, myeloid cell leukemia 1, myeloid cell leukemia ES, myeloid cell leukemia sequence 1, myeloid cell leukemia sequence 1 (BCL2-related), TM
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17210, 4170, 60430
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P97287, Q07820, Q9Z1P3
Gene Symbols:
MCL1
Immunogen:
Synthetic peptide, corresponding to amino acids 100-150 of Human Mcl-1.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: MCM2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MCM2
Gene Alias: AA959861, AW476101, BM28, CCNL1, cdc19, CDCL1, cell devision cycle-like 1, cyclin-like 1, D3S3194, DFNA70, DNA replication licensing factor MCM2, Kiaa0030, MCM DNA helicase complex subunit MCM2, Mcm2, Mcmd2, MGC10606, mini chromosome maintenance deficient 2, minichromosome maintenance complex component 2, minichromosome maintenance deficient 2 (mitotin), minichromosome maintenance deficient 2 mitotin, minichromosome maintenance deficient 2 mitotin (S. cerevisiae), Minichromosome maintenance protein 2, Minichromosome maintenance protein 2 homolog, MITOTIN, mKIAA0030, Nuclear protein BM28, YBL023C, YBL0438
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17216, 312538, 4171
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P49736, P97310
Gene Symbols: MCM2
Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human MCM2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MCM2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MCM2
Gene Alias:
AA959861, AW476101, BM28, CCNL1, cdc19, CDCL1, cell devision cycle-like 1, cyclin-like 1, D3S3194, DFNA70, DNA replication licensing factor MCM2, Kiaa0030, MCM DNA helicase complex subunit MCM2, Mcm2, Mcmd2, MGC10606, mini chromosome maintenance deficient 2, minichromosome maintenance complex component 2, minichromosome maintenance deficient 2 (mitotin), minichromosome maintenance deficient 2 mitotin, minichromosome maintenance deficient 2 mitotin (S. cerevisiae), Minichromosome maintenance protein 2, Minichromosome maintenance protein 2 homolog, MITOTIN, mKIAA0030, Nuclear protein BM28, YBL023C, YBL0438
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17216, 312538, 4171
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P49736, P97310
Gene Symbols:
MCM2
Immunogen:
Synthetic peptide, corresponding to amino acids N-terminus of Human MCM2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: MDM2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17246, 314856, 4193
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P23804, Q00987
Gene Symbols: MDM2
Immunogen: Synthetic peptide, corresponding to amino acids 385-430 of Human MDM2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MDM2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17246, 314856, 4193
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P23804, Q00987
Gene Symbols:
MDM2
Immunogen:
Synthetic peptide, corresponding to amino acids 385-430 of Human MDM2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: MEF2A
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MEF2A
Gene Alias: A430079H05Rik, ADCAD1, C5DELq14.3, DEL5q14.3, MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A), MADS box transcription enhancer factor 2, polypeptide C, mef2, Mef2a, MEF2C, myocyte enhancer factor 2a, myocyte enhancer factor 2C, Myocyte-specific enhancer factor 2A, myocyte-specific enhancer factor 2C, RSRFC4, RSRFC9, Serum response factor-like protein 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17258, 309957, 4205
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: Q02078, Q2MJT0, Q60929
Gene Symbols: MEF2A
Immunogen: Synthetic peptide, corresponding to amino acids 280-330 of Human MEF-2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MEF2A
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MEF2A
Gene Alias:
A430079H05Rik, ADCAD1, C5DELq14.3, DEL5q14.3, MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A), MADS box transcription enhancer factor 2, polypeptide C, mef2, Mef2a, MEF2C, myocyte enhancer factor 2a, myocyte enhancer factor 2C, Myocyte-specific enhancer factor 2A, myocyte-specific enhancer factor 2C, RSRFC4, RSRFC9, Serum response factor-like protein 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17258, 309957, 4205
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
Q02078, Q2MJT0, Q60929
Gene Symbols:
MEF2A
Immunogen:
Synthetic peptide, corresponding to amino acids 280-330 of Human MEF-2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG