PIPA586176
MDM2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA586176-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA586176 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
MDM2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17246, 314856, 4193
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.
P23804, Q00987
Gene Symbols
MDM2
Immunogen
Synthetic peptide, corresponding to amino acids 385-430 of Human MDM2.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human malignancies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
Compare Similar Items
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Antigen: MDM2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17246, 314856, 4193
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P23804, Q00987
Gene Symbols: MDM2
Immunogen: Synthetic peptide, corresponding to amino acids 385-430 of Human MDM2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MDM2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17246, 314856, 4193
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P23804, Q00987
Gene Symbols:
MDM2
Immunogen:
Synthetic peptide, corresponding to amino acids 385-430 of Human MDM2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: MEF2A
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MEF2A
Gene Alias: A430079H05Rik, ADCAD1, C5DELq14.3, DEL5q14.3, MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A), MADS box transcription enhancer factor 2, polypeptide C, mef2, Mef2a, MEF2C, myocyte enhancer factor 2a, myocyte enhancer factor 2C, Myocyte-specific enhancer factor 2A, myocyte-specific enhancer factor 2C, RSRFC4, RSRFC9, Serum response factor-like protein 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17258, 309957, 4205
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: Q02078, Q2MJT0, Q60929
Gene Symbols: MEF2A
Immunogen: Synthetic peptide, corresponding to amino acids 280-330 of Human MEF-2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MEF2A
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MEF2A
Gene Alias:
A430079H05Rik, ADCAD1, C5DELq14.3, DEL5q14.3, MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A), MADS box transcription enhancer factor 2, polypeptide C, mef2, Mef2a, MEF2C, myocyte enhancer factor 2a, myocyte enhancer factor 2C, Myocyte-specific enhancer factor 2A, myocyte-specific enhancer factor 2C, RSRFC4, RSRFC9, Serum response factor-like protein 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17258, 309957, 4205
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
Q02078, Q2MJT0, Q60929
Gene Symbols:
MEF2A
Immunogen:
Synthetic peptide, corresponding to amino acids 280-330 of Human MEF-2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: MEF2A
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MEF2A
Gene Alias: A430079H05Rik, ADCAD1, C5DELq14.3, DEL5q14.3, MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A), MADS box transcription enhancer factor 2, polypeptide C, mef2, Mef2a, MEF2C, myocyte enhancer factor 2a, myocyte enhancer factor 2C, Myocyte-specific enhancer factor 2A, myocyte-specific enhancer factor 2C, RSRFC4, RSRFC9, Serum response factor-like protein 1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17258, 309957, 4205
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: Q02078, Q2MJT0, Q60929
Gene Symbols: MEF2A
Immunogen: Synthetic peptide, corresponding to amino acids 300-350 of Human MEF-2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MEF2A
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MEF2A
Gene Alias:
A430079H05Rik, ADCAD1, C5DELq14.3, DEL5q14.3, MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A), MADS box transcription enhancer factor 2, polypeptide C, mef2, Mef2a, MEF2C, myocyte enhancer factor 2a, myocyte enhancer factor 2C, Myocyte-specific enhancer factor 2A, myocyte-specific enhancer factor 2C, RSRFC4, RSRFC9, Serum response factor-like protein 1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17258, 309957, 4205
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
Q02078, Q2MJT0, Q60929
Gene Symbols:
MEF2A
Immunogen:
Synthetic peptide, corresponding to amino acids 300-350 of Human MEF-2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: MEK2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MAP2K2
Gene Alias: AA589381, CFC4, Dual specificity mitogen-activated protein kinase kinase 2, ERK activator kinase 2, ERK kinase 2, FLJ26075, MAP kinase kinase 2, MAP kinase/Erk kinase, MAP2K1, MAP2K2, MAPK, MAPK/ERK kinase 1, MAPK/ERK kinase 2, MAPKK 1, MAPKK 2, MAPKK2, MEK 1, MEK 2, MEK-1, Mek2, MEK-2, mitogen activated protein kinase kinase 2, mitogen-activated protein kinase kinase 2, mitogen-activated protein kinase kinase 2, p45, MK2, MKK1, Mkk2, OTTHUMP00000165827, PRKMK1, PRKMK2, protein kinase, mitogen activated, kinase 2, p45
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 26396, 5605, 58960
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P36506, P36507, Q63932
Gene Symbols: MAP2K2
Immunogen: Synthetic peptide, corresponding to amino acids C-terminus of Human MEK-2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MEK2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MAP2K2
Gene Alias:
AA589381, CFC4, Dual specificity mitogen-activated protein kinase kinase 2, ERK activator kinase 2, ERK kinase 2, FLJ26075, MAP kinase kinase 2, MAP kinase/Erk kinase, MAP2K1, MAP2K2, MAPK, MAPK/ERK kinase 1, MAPK/ERK kinase 2, MAPKK 1, MAPKK 2, MAPKK2, MEK 1, MEK 2, MEK-1, Mek2, MEK-2, mitogen activated protein kinase kinase 2, mitogen-activated protein kinase kinase 2, mitogen-activated protein kinase kinase 2, p45, MK2, MKK1, Mkk2, OTTHUMP00000165827, PRKMK1, PRKMK2, protein kinase, mitogen activated, kinase 2, p45
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
26396, 5605, 58960
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P36506, P36507, Q63932
Gene Symbols:
MAP2K2
Immunogen:
Synthetic peptide, corresponding to amino acids C-terminus of Human MEK-2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG