PIPA586249
MDM2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA586249-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA586249 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
MDM2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17246, 314856, 4193
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.
P23804, Q00987
Gene Symbols
MDM2
Immunogen
Synthetic peptide, corresponding to amino acids 130-180 of Human MDM2.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human malignancies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
Compare Similar Items
Show Difference
Antigen: MDM2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17246, 314856, 4193
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P23804, Q00987
Gene Symbols: MDM2
Immunogen: Synthetic peptide, corresponding to amino acids 130-180 of Human MDM2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MDM2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17246, 314856, 4193
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P23804, Q00987
Gene Symbols:
MDM2
Immunogen:
Synthetic peptide, corresponding to amino acids 130-180 of Human MDM2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: RSK1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: RPS6KA1
Gene Alias: 90 kDa ribosomal protein S6 kinase 1, dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1), hu-1, MAP kinase-activated protein kinase 1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1, MAPK-activated protein kinase 1a, MAPKAP kinase 1, MAPKAP kinase 1a, MAPKAPK-1, mapkapk1a, MAPKAPK-1a, p90Rsk, P90-RSK, p90-RSK 1, p90Rsk1, p90-Rsk1, p90S6K, pp90RSK1, ribosomal protein S6 kinase 2 alpha, ribosomal protein S6 kinase 2 beta, ribosomal protein S6 kinase a, polypeptide 1, ribosomal protein S6 kinase A1, ribosomal protein S6 kinase A1 L homeolog, ribosomal protein S6 kinase alpha 1, Ribosomal protein S6 kinase alpha-1, Ribosomal protein S6 kinase II alpha, ribosomal protein S6 kinase II beta, ribosomal protein S6 kinase polypeptide 1, ribosomal protein S6 kinase, 90kD, polypeptide 1, Ribosomal protein S6 kinase, 90kD, 1, ribosomal protein S6 kinase, 90kDa, polypeptide 1, ribosomal protein S6 kinase, 90kDa, polypeptide 1 L homeolog, ribosomal protein S6 kinas
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20111, 6195, 81771
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P18653, Q15418, Q63531
Gene Symbols: RPS6KA1
Immunogen: Synthetic peptide, corresponding to amino acids 343-396 of Human Rsk-1.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
RSK1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
RPS6KA1
Gene Alias:
90 kDa ribosomal protein S6 kinase 1, dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1), hu-1, MAP kinase-activated protein kinase 1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1, MAPK-activated protein kinase 1a, MAPKAP kinase 1, MAPKAP kinase 1a, MAPKAPK-1, mapkapk1a, MAPKAPK-1a, p90Rsk, P90-RSK, p90-RSK 1, p90Rsk1, p90-Rsk1, p90S6K, pp90RSK1, ribosomal protein S6 kinase 2 alpha, ribosomal protein S6 kinase 2 beta, ribosomal protein S6 kinase a, polypeptide 1, ribosomal protein S6 kinase A1, ribosomal protein S6 kinase A1 L homeolog, ribosomal protein S6 kinase alpha 1, Ribosomal protein S6 kinase alpha-1, Ribosomal protein S6 kinase II alpha, ribosomal protein S6 kinase II beta, ribosomal protein S6 kinase polypeptide 1, ribosomal protein S6 kinase, 90kD, polypeptide 1, Ribosomal protein S6 kinase, 90kD, 1, ribosomal protein S6 kinase, 90kDa, polypeptide 1, ribosomal protein S6 kinase, 90kDa, polypeptide 1 L homeolog, ribosomal protein S6 kinas
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20111, 6195, 81771
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P18653, Q15418, Q63531
Gene Symbols:
RPS6KA1
Immunogen:
Synthetic peptide, corresponding to amino acids 343-396 of Human Rsk-1.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Cardiac Troponin I
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TNNI3
Gene Alias: alternatively spliced, cardiac ankyrin repeat kinase, Cardiac muscle troponin T, cardiac troponin I, cardiac troponin I isoform, cardiac troponin I-interacting kinase, cardiac troponin T, cardiac troponin T isoform 1, cardiac troponin T isoform 2, cardiac troponin T2, cardiomyopathy, dilated 1D (autosomal dominant), cardiomyopathy, dilated 2A (autosomal recessive), cardiomyopathy, hypertrophic 2, CARK, CCDD, CMD1D, CMD1FF, CMD2A, CMH2, CMH7, CMPD2, cTnI, cTnT, Ctt, CTTG, D830019J24Rik, LVNC6, MGC116817, RATCTTG, RCM1, RCM3, Serine/threonine-protein kinase TNNI3K, Tn1, TnI, TNNC1, Tnni3, TNNI3 interacting kinase, TNNI3-interacting kinase, TNNI3K, tnni3k {ECO:0000250, TNNT2, Tnnt3, TnTc, Tpn1, troponin 1, type 3, troponin I type 3 (cardiac), troponin I, cardiac 3, troponin I, cardiac muscle, troponin I, cardiac muscle-like, troponin I3, cardiac type, Troponin T cardiac, troponin T cardiac isoform, troponin T isoform 1, troponin T isoform 2, troponin T splicing mutant isoform 1, troponin
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 21954, 29248, 7137
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.05% sodium azide, pH 7.2
Gene Accession No.: P19429, P23693, P48787
Gene Symbols: TNNI3
Immunogen: Synthetic peptide from the N-terminus of Human Cardiac Troponin I.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Cardiac Troponin I
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TNNI3
Gene Alias:
alternatively spliced, cardiac ankyrin repeat kinase, Cardiac muscle troponin T, cardiac troponin I, cardiac troponin I isoform, cardiac troponin I-interacting kinase, cardiac troponin T, cardiac troponin T isoform 1, cardiac troponin T isoform 2, cardiac troponin T2, cardiomyopathy, dilated 1D (autosomal dominant), cardiomyopathy, dilated 2A (autosomal recessive), cardiomyopathy, hypertrophic 2, CARK, CCDD, CMD1D, CMD1FF, CMD2A, CMH2, CMH7, CMPD2, cTnI, cTnT, Ctt, CTTG, D830019J24Rik, LVNC6, MGC116817, RATCTTG, RCM1, RCM3, Serine/threonine-protein kinase TNNI3K, Tn1, TnI, TNNC1, Tnni3, TNNI3 interacting kinase, TNNI3-interacting kinase, TNNI3K, tnni3k {ECO:0000250, TNNT2, Tnnt3, TnTc, Tpn1, troponin 1, type 3, troponin I type 3 (cardiac), troponin I, cardiac 3, troponin I, cardiac muscle, troponin I, cardiac muscle-like, troponin I3, cardiac type, Troponin T cardiac, troponin T cardiac isoform, troponin T isoform 1, troponin T isoform 2, troponin T splicing mutant isoform 1, troponin
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
21954, 29248, 7137
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.05% sodium azide, pH 7.2
Gene Accession No.:
P19429, P23693, P48787
Gene Symbols:
TNNI3
Immunogen:
Synthetic peptide from the N-terminus of Human Cardiac Troponin I.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Cardiac Troponin I
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TNNI3
Gene Alias: alternatively spliced, cardiac ankyrin repeat kinase, Cardiac muscle troponin T, cardiac troponin I, cardiac troponin I isoform, cardiac troponin I-interacting kinase, cardiac troponin T, cardiac troponin T isoform 1, cardiac troponin T isoform 2, cardiac troponin T2, cardiomyopathy, dilated 1D (autosomal dominant), cardiomyopathy, dilated 2A (autosomal recessive), cardiomyopathy, hypertrophic 2, CARK, CCDD, CMD1D, CMD1FF, CMD2A, CMH2, CMH7, CMPD2, cTnI, cTnT, Ctt, CTTG, D830019J24Rik, LVNC6, MGC116817, RATCTTG, RCM1, RCM3, Serine/threonine-protein kinase TNNI3K, Tn1, TnI, TNNC1, Tnni3, TNNI3 interacting kinase, TNNI3-interacting kinase, TNNI3K, tnni3k {ECO:0000250, TNNT2, Tnnt3, TnTc, Tpn1, troponin 1, type 3, troponin I type 3 (cardiac), troponin I, cardiac 3, troponin I, cardiac muscle, troponin I, cardiac muscle-like, troponin I3, cardiac type, Troponin T cardiac, troponin T cardiac isoform, troponin T isoform 1, troponin T isoform 2, troponin T splicing mutant isoform 1, troponin
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 21954, 29248, 7137
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.: P19429, P23693, P48787
Gene Symbols: TNNI3
Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Troponin I3.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Cardiac Troponin I
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TNNI3
Gene Alias:
alternatively spliced, cardiac ankyrin repeat kinase, Cardiac muscle troponin T, cardiac troponin I, cardiac troponin I isoform, cardiac troponin I-interacting kinase, cardiac troponin T, cardiac troponin T isoform 1, cardiac troponin T isoform 2, cardiac troponin T2, cardiomyopathy, dilated 1D (autosomal dominant), cardiomyopathy, dilated 2A (autosomal recessive), cardiomyopathy, hypertrophic 2, CARK, CCDD, CMD1D, CMD1FF, CMD2A, CMH2, CMH7, CMPD2, cTnI, cTnT, Ctt, CTTG, D830019J24Rik, LVNC6, MGC116817, RATCTTG, RCM1, RCM3, Serine/threonine-protein kinase TNNI3K, Tn1, TnI, TNNC1, Tnni3, TNNI3 interacting kinase, TNNI3-interacting kinase, TNNI3K, tnni3k {ECO:0000250, TNNT2, Tnnt3, TnTc, Tpn1, troponin 1, type 3, troponin I type 3 (cardiac), troponin I, cardiac 3, troponin I, cardiac muscle, troponin I, cardiac muscle-like, troponin I3, cardiac type, Troponin T cardiac, troponin T cardiac isoform, troponin T isoform 1, troponin T isoform 2, troponin T splicing mutant isoform 1, troponin
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
21954, 29248, 7137
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
Gene Accession No.:
P19429, P23693, P48787
Gene Symbols:
TNNI3
Immunogen:
Synthetic peptide, corresponding to amino acids 100-150 of Human Troponin I3.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG