PIPA587423
MDM2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA587423-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA587423 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
MDM2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17246, 4193
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot, Immunohistochemistry, Western Blot
Concentration
0.49 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
P23804, Q00987
Gene Symbols
MDM2
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 231-330 of human MDM2 (NP_0013549191)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: SKOV3, HT-29, Jurkat; Cellular Location: Cytoplasm, Nucleus, nucleolus, nucleoplasm Immunogen sequence: HSGDWLDQDS VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA DYWKCTSCNE MNPPLPSHCN RCWALRENWL MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human malignancies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
Compare Similar Items
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Antigen: MDM2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17246, 4193
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot, Immunohistochemistry, Western Blot
Concentration: 0.49 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: P23804, Q00987
Gene Symbols: MDM2
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 231-330 of human MDM2 (NP_0013549191)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
MDM2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik, AA415488, ACTFS, double minute 2, double minute 2 protein, double minute 2, human homolog of, p53-binding protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, HGNC:6973, human homolog of, MDM2, Mdm-2, MDM2 oncogene, E3 ubiquitin protein ligase, Mdm2 p53 binding protein homolog, MDM2 proto-oncogene, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, oncoprotein Mdm2, OTTHUMP00000183490, OTTHUMP00000183492, OTTHUMP00000183494, OTTHUMP00000183495, OTTHUMP00000183496, OTTHUMP00000183497, p53 E3 ubiquitin protein ligase, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2, transformed mouse 3T3 cell double minute 2
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17246, 4193
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot, Immunohistochemistry, Western Blot
Concentration:
0.49 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
P23804, Q00987
Gene Symbols:
MDM2
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 231-330 of human MDM2 (NP_0013549191)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CD4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CD4
Gene Alias: Activation B7-1 antigen, B7, B7.1, B7-1, BB1, B-lymphocyte activation antigen B7, CD28LG, CD28LG1, CD4, CD4 antigen, CD4 antigen (p55), CD4 antigen p55, Cd4 molecule, CD4 precursor, CD4 receptor, CD4, allele 1, cd4a, CD4mut, CD80, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80 molecule, cell surface glycoprotein CD4, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, fCD4, L3T4, LAB7, Leu-3, Ly-4, lymphocyte antigen CD4, lymphocyte antigen CD4 precursor, membrane protein, p55, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4), T-lymphocyte activation antigen CD80, W3/25, W3/25 antigen
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12504, 24932, 920
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.22 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: P01730, P05540, P06332
Gene Symbols: CD4
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 26-200 of human CD4 (NP_0006071)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
CD4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CD4
Gene Alias:
Activation B7-1 antigen, B7, B7.1, B7-1, BB1, B-lymphocyte activation antigen B7, CD28LG, CD28LG1, CD4, CD4 antigen, CD4 antigen (p55), CD4 antigen p55, Cd4 molecule, CD4 precursor, CD4 receptor, CD4, allele 1, cd4a, CD4mut, CD80, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD80 molecule, cell surface glycoprotein CD4, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, fCD4, L3T4, LAB7, Leu-3, Ly-4, lymphocyte antigen CD4, lymphocyte antigen CD4 precursor, membrane protein, p55, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4), T-lymphocyte activation antigen CD80, W3/25, W3/25 antigen
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12504, 24932, 920
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.22 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P01730, P05540, P06332
Gene Symbols:
CD4
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-200 of human CD4 (NP_0006071)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: VHL
Classification: Polyclonal
Conjugate: Unconjugated
Gene: VHL
Gene Alias: elongin binding protein, HRCA1, Protein G7, pVHL, RCA1, VHL, VHL1, VHL19, Vhlh, VHLp18(MEA), Von Hippel Lindau, von hippel-lindau, von Hippel-Lindau disease tumor suppressor, von Hippel-Lindau syndrome homolog, von Hippel-Lindau syndrome protein homolog, von Hippel-Lindau tumor suppressor, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 22346, 24874, 7428
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 2.84 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: P40337, P40338, Q64259
Gene Symbols: VHL
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 87-186 of human VHL (NP_0005421)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
VHL
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
VHL
Gene Alias:
elongin binding protein, HRCA1, Protein G7, pVHL, RCA1, VHL, VHL1, VHL19, Vhlh, VHLp18(MEA), Von Hippel Lindau, von hippel-lindau, von Hippel-Lindau disease tumor suppressor, von Hippel-Lindau syndrome homolog, von Hippel-Lindau syndrome protein homolog, von Hippel-Lindau tumor suppressor, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22346, 24874, 7428
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
2.84 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
P40337, P40338, Q64259
Gene Symbols:
VHL
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 87-186 of human VHL (NP_0005421)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: TNFR2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Tnfrsf1b
Gene Alias: CD120b, Etanercept, p75, p75 TNF receptor, p75 TNFR, p75TNFR, p80 TNF-alpha receptor, sCD120b, soluble CD120b, soluble TNFR1B variant 1, soluble TNFR2, sTNF R2, sTNFR 2, sTNFR2, TBP-2, TBPII, TNF receptor beta chain, TNF receptor superfamily member 1B, TNF-alphaR2, TNFalpha-R2, TNFBR, TNFR, TNFR II, Tnfr-1, TNFR1B, TNFR2, TNF-R2, Tnfr-2, TNF-R75, TNFR80, TNFRII, TNF-RII, TNF-R-II, TNFR-II, TNFRSF1B, tumor necrosis factor beta receptor, tumor necrosis factor binding protein 2, Tumor necrosis factor receptor, tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor superfamily member 1b, membrane form, tumor necrosis factor receptor superfamily, member 1B, tumor necrosis factor receptor type II, Tumor necrosis factor-binding protein 2
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 7133
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 2.02 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P20333
Gene Symbols: Tnfrsf1b
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-250 of human TNFR2/TNFR2/TNFRSF1B (NP_0010571)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
TNFR2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Tnfrsf1b
Gene Alias:
CD120b, Etanercept, p75, p75 TNF receptor, p75 TNFR, p75TNFR, p80 TNF-alpha receptor, sCD120b, soluble CD120b, soluble TNFR1B variant 1, soluble TNFR2, sTNF R2, sTNFR 2, sTNFR2, TBP-2, TBPII, TNF receptor beta chain, TNF receptor superfamily member 1B, TNF-alphaR2, TNFalpha-R2, TNFBR, TNFR, TNFR II, Tnfr-1, TNFR1B, TNFR2, TNF-R2, Tnfr-2, TNF-R75, TNFR80, TNFRII, TNF-RII, TNF-R-II, TNFR-II, TNFRSF1B, tumor necrosis factor beta receptor, tumor necrosis factor binding protein 2, Tumor necrosis factor receptor, tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor superfamily member 1b, membrane form, tumor necrosis factor receptor superfamily, member 1B, tumor necrosis factor receptor type II, Tumor necrosis factor-binding protein 2
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
7133
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
2.02 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P20333
Gene Symbols:
Tnfrsf1b
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-250 of human TNFR2/TNFR2/TNFRSF1B (NP_0010571)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG