PIPA588063
Cyclin D1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA588063-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA588063 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
Cyclin D1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CCND1
Gene Alias
AI327039, B-cell CLL/lymphoma 1, B-cell lymphoma 1 protein, BCL1, BCL-1, BCL-1 oncogene, CCND1, CCND1 protein, cD1, cDNA, CycD1, cyclin D1, Cyl-1, D11S287E, FLJ93625, G1/S-specific cyclin-D1, mRNA, PRAD1, PRAD-1, PRAD1 oncogene, U21B31
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12443, 58919, 595
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
1.81 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
P24385, P25322, P39948
Gene Symbols
CCND1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 200-295 of human Cyclin D1 (NP_4442841)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: U-87MG, HepG2, SW480, HT-1080, Mouse kidney; Cellular Location: Cytoplasm, Membrane, Nucleus Immunogen sequence: PSMVAAGSVV AAVQGLNLRS PNNFLSYYRL TRFLSRVIKC DPDCLRACQE QIEALLESSL RQAQQNMDPK AAEEEEEEEE EVDLACTPTD VRDVDI Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein
- Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL)
- In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation
- In humans, the CCND1 gene encoding cyclin D1 is present on chromosome 11
- Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation
- D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1
- Without growth factor-mediated stimulation, Cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation
- Cyclin D1 destabilization participates in G1/S phase arrest
- The Cyclin D1 protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle
- Cyclins function as regulators of CDK kinases
- Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event
- Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition
- The Cyclin D1 protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb
- Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis
- Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.
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Antigen: Cyclin D1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CCND1
Gene Alias: AI327039, B-cell CLL/lymphoma 1, B-cell lymphoma 1 protein, BCL1, BCL-1, BCL-1 oncogene, CCND1, CCND1 protein, cD1, cDNA, CycD1, cyclin D1, Cyl-1, D11S287E, FLJ93625, G1/S-specific cyclin-D1, mRNA, PRAD1, PRAD-1, PRAD1 oncogene, U21B31
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12443, 58919, 595
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1.81 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: P24385, P25322, P39948
Gene Symbols: CCND1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 200-295 of human Cyclin D1 (NP_4442841)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Cyclin D1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CCND1
Gene Alias:
AI327039, B-cell CLL/lymphoma 1, B-cell lymphoma 1 protein, BCL1, BCL-1, BCL-1 oncogene, CCND1, CCND1 protein, cD1, cDNA, CycD1, cyclin D1, Cyl-1, D11S287E, FLJ93625, G1/S-specific cyclin-D1, mRNA, PRAD1, PRAD-1, PRAD1 oncogene, U21B31
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12443, 58919, 595
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1.81 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P24385, P25322, P39948
Gene Symbols:
CCND1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-295 of human Cyclin D1 (NP_4442841)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: BAG1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Bag1
Gene Alias: BAG family molecular chaperone regulator 1, Bag1, BAG-1, BCL2 associated athanogene 1, Bcl-2 associating athanogene-1 protein, BCL2-associated athanogene, bcl-2-associated athanogene 1, BCL2-associated athanogene 1, Bcl-2-binding protein, glucocortoid receptor-associated protein RAP46, HAP, Rap46, receptor-associated protein, 46-KD, RP11-326F20.2
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12017, 573
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Western Blot, Western Blot
Concentration: 0.33 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: Q60739, Q99933
Gene Symbols: Bag1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human BAG1 (NP_0011658861)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
BAG1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Bag1
Gene Alias:
BAG family molecular chaperone regulator 1, Bag1, BAG-1, BCL2 associated athanogene 1, Bcl-2 associating athanogene-1 protein, BCL2-associated athanogene, bcl-2-associated athanogene 1, BCL2-associated athanogene 1, Bcl-2-binding protein, glucocortoid receptor-associated protein RAP46, HAP, Rap46, receptor-associated protein, 46-KD, RP11-326F20.2
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12017, 573
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot, Western Blot
Concentration:
0.33 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
Q60739, Q99933
Gene Symbols:
Bag1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human BAG1 (NP_0011658861)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: Bcl-10
Classification: Polyclonal
Conjugate: Unconjugated
Gene: BCL10
Gene Alias: AI132454, B cell CLL/lymphoma 10, B cell leukemia/lymphoma 10, B-cell CLL/lymphoma 10, B-cell leukemia/lymphoma 10, B-cell lymphoma/leukemia 10, BCL10, Bcl-10, BCL10 immune signaling adaptor, C81403, CARD containing molecule enhancing NF-kB, CARD-containing apoptotic signaling protein, CARD-containing molecule enhancing NF-kappa-B, CARD-containing proapoptotic protein, CARD-like apoptotic protein, CARMEN, caspase-recruiting domain-containing protein, cCARMEN, cE10, c-E10, CED-3/ICH-1 prodomain homologous E10-like regulator, cellular homolog of vCARMEN, Cellular-E10, CIPER, Clap, hCLAP, IMD37, Mamm, mammalian CARD-containing adapter molecule E10, mCIPER, mCLAP, mE10, OTTHUMP00000011647, OTTHUMP00000036080, RCD, RP11-234D19.2, R-RCD1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12042, 83477, 8915
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 2.13 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: O95999, Q9QYN5, Q9Z0H7
Gene Symbols: BCL10
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human Bcl10 (NP_0039121)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Bcl-10
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
BCL10
Gene Alias:
AI132454, B cell CLL/lymphoma 10, B cell leukemia/lymphoma 10, B-cell CLL/lymphoma 10, B-cell leukemia/lymphoma 10, B-cell lymphoma/leukemia 10, BCL10, Bcl-10, BCL10 immune signaling adaptor, C81403, CARD containing molecule enhancing NF-kB, CARD-containing apoptotic signaling protein, CARD-containing molecule enhancing NF-kappa-B, CARD-containing proapoptotic protein, CARD-like apoptotic protein, CARMEN, caspase-recruiting domain-containing protein, cCARMEN, cE10, c-E10, CED-3/ICH-1 prodomain homologous E10-like regulator, cellular homolog of vCARMEN, Cellular-E10, CIPER, Clap, hCLAP, IMD37, Mamm, mammalian CARD-containing adapter molecule E10, mCIPER, mCLAP, mE10, OTTHUMP00000011647, OTTHUMP00000036080, RCD, RP11-234D19.2, R-RCD1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12042, 83477, 8915
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
2.13 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
O95999, Q9QYN5, Q9Z0H7
Gene Symbols:
BCL10
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human Bcl10 (NP_0039121)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: DNMT3B
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Dnmt3b
Gene Alias: DNA (cytosine-5-)-methyltransferase 3 beta, DNA (cytosine-5)-methyltransferase 3B, DNA methyltransferase 3 beta, DNA methyltransferase 3B, DNA methyltransferase HsaIIIB, DNA methyltransferase MmuIIIB, DNA MTase HsaIIIB, DNA MTase MmuIIIB, Dnmt3, DNMT3B, ICF, ICF1, M.HsaIIIB, m.MmuIIIB, MGC1090, MmuIIIB
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 13436, 1789, 444985
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.95 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: O88509, Q9UBC3
Gene Symbols: Dnmt3b
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DNMT3B (NP_0088231)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
DNMT3B
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Dnmt3b
Gene Alias:
DNA (cytosine-5-)-methyltransferase 3 beta, DNA (cytosine-5)-methyltransferase 3B, DNA methyltransferase 3 beta, DNA methyltransferase 3B, DNA methyltransferase HsaIIIB, DNA methyltransferase MmuIIIB, DNA MTase HsaIIIB, DNA MTase MmuIIIB, Dnmt3, DNMT3B, ICF, ICF1, M.HsaIIIB, m.MmuIIIB, MGC1090, MmuIIIB
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13436, 1789, 444985
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.95 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
O88509, Q9UBC3
Gene Symbols:
Dnmt3b
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DNMT3B (NP_0088231)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG