PIPA588111
Cyclin D1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA588111-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA588111 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
Cyclin D1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CCND1
Gene Alias
AI327039, B-cell CLL/lymphoma 1, B-cell lymphoma 1 protein, BCL1, BCL-1, BCL-1 oncogene, CCND1, CCND1 protein, cD1, cDNA, CycD1, cyclin D1, Cyl-1, D11S287E, FLJ93625, G1/S-specific cyclin-D1, mRNA, PRAD1, PRAD-1, PRAD1 oncogene, U21B31
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12443, 595
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunoprecipitation, Western Blot, Western Blot
Concentration
2.51 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
P24385, P25322
Gene Symbols
CCND1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-295 of human Cyclin D1 (NP_4442841)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: PSMVAAGSVV AAVQGLNLRS PNNFLSYYRL TRFLSRVIKC DPDCLRACQE QIEALLESSL RQAQQNMDPK AAEEEEEEEE EVDLACTPTD VRDVDI; Positive Samples: U-87MG, HepG2, SW480, HT-1080; Cellular Location: Cytoplasm, Membrane, Nucleus Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein
- Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL)
- In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation
- In humans, the CCND1 gene encoding cyclin D1 is present on chromosome 11
- Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation
- D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1
- Without growth factor-mediated stimulation, Cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation
- Cyclin D1 destabilization participates in G1/S phase arrest
- The Cyclin D1 protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle
- Cyclins function as regulators of CDK kinases
- Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event
- Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition
- The Cyclin D1 protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb
- Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis
- Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.
Compare Similar Items
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Antigen: Cyclin D1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CCND1
Gene Alias: AI327039, B-cell CLL/lymphoma 1, B-cell lymphoma 1 protein, BCL1, BCL-1, BCL-1 oncogene, CCND1, CCND1 protein, cD1, cDNA, CycD1, cyclin D1, Cyl-1, D11S287E, FLJ93625, G1/S-specific cyclin-D1, mRNA, PRAD1, PRAD-1, PRAD1 oncogene, U21B31
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12443, 595
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunoprecipitation, Western Blot, Western Blot
Concentration: 2.51 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: P24385, P25322
Gene Symbols: CCND1
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-295 of human Cyclin D1 (NP_4442841)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Cyclin D1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CCND1
Gene Alias:
AI327039, B-cell CLL/lymphoma 1, B-cell lymphoma 1 protein, BCL1, BCL-1, BCL-1 oncogene, CCND1, CCND1 protein, cD1, cDNA, CycD1, cyclin D1, Cyl-1, D11S287E, FLJ93625, G1/S-specific cyclin-D1, mRNA, PRAD1, PRAD-1, PRAD1 oncogene, U21B31
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12443, 595
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot, Western Blot
Concentration:
2.51 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P24385, P25322
Gene Symbols:
CCND1
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-295 of human Cyclin D1 (NP_4442841)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Emerin
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Emd
Gene Alias: AW550900, EDMD, EMD, Emerin, LEM domain containing 5, LEMD5, STA
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 2010
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 4.74 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: P50402
Gene Symbols: Emd
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human Emerin/Emerin/EMD (NP_0001081)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Emerin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Emd
Gene Alias:
AW550900, EDMD, EMD, Emerin, LEM domain containing 5, LEMD5, STA
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
2010
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
4.74 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
P50402
Gene Symbols:
Emd
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human Emerin/Emerin/EMD (NP_0001081)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CTCF
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CTCF
Gene Alias: 11 zinc finger transcriptional repressor, 11-zinc finger protein, AW108038, CCCTC-binding factor, CCCTC-binding factor (zinc finger protein), Ctcf, ctcf protein, CTCFL paralog, im:7152666, MRD21, OTTHUMP00000197610, Transcriptional repressor CTCF, Unknown (protein for IMAGE:8125283)
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10664, 13018, 83726
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: ChIP Assay, Immunocytochemistry, Immunoprecipitation, Western Blot, Western Blot
Concentration: 3.18 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: P49711, Q61164, Q9R1D1
Gene Symbols: CTCF
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CTCF (NP_0065561)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
CTCF
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CTCF
Gene Alias:
11 zinc finger transcriptional repressor, 11-zinc finger protein, AW108038, CCCTC-binding factor, CCCTC-binding factor (zinc finger protein), Ctcf, ctcf protein, CTCFL paralog, im:7152666, MRD21, OTTHUMP00000197610, Transcriptional repressor CTCF, Unknown (protein for IMAGE:8125283)
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10664, 13018, 83726
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
ChIP Assay, Immunocytochemistry, Immunoprecipitation, Western Blot, Western Blot
Concentration:
3.18 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
P49711, Q61164, Q9R1D1
Gene Symbols:
CTCF
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CTCF (NP_0065561)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CHOP
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DDIT3
Gene Alias: C/EBP homologous protein, C/EBP homoologous protein 10, C/EBP zeta, C/EBP-homologous protein, C/EBP-homologous protein 10, CCAAT/enhancer-binding protein homologous protein, CEBPZ, CHOP, CHOP10, CHOP-10, Ddit3, DDIT-3, ddit3.L, DNA damage inducible transcript 3, DNA damage inducible transcript 3 L homeolog, DNA damage-inducible transcript 3 protein, DNA-damage inducible transcript 3, DNA-damage-inducible transcript 3, GADD153, growth arrest and DNA damage-inducible, growth arrest and DNA damage-inducible protein GADD153, Growth arrest and DNA-damage-inducible protein GADD153, MGC4154, transcription factor GADD153, Xchop, XELAEV_18013440mg
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 13198, 1649, 29467
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 2.52 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: P35638, P35639, Q62857
Gene Symbols: DDIT3
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DDIT3/CHOP (NP_0040742)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
CHOP
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DDIT3
Gene Alias:
C/EBP homologous protein, C/EBP homoologous protein 10, C/EBP zeta, C/EBP-homologous protein, C/EBP-homologous protein 10, CCAAT/enhancer-binding protein homologous protein, CEBPZ, CHOP, CHOP10, CHOP-10, Ddit3, DDIT-3, ddit3.L, DNA damage inducible transcript 3, DNA damage inducible transcript 3 L homeolog, DNA damage-inducible transcript 3 protein, DNA-damage inducible transcript 3, DNA-damage-inducible transcript 3, GADD153, growth arrest and DNA damage-inducible, growth arrest and DNA damage-inducible protein GADD153, Growth arrest and DNA-damage-inducible protein GADD153, MGC4154, transcription factor GADD153, Xchop, XELAEV_18013440mg
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
13198, 1649, 29467
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
2.52 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P35638, P35639, Q62857
Gene Symbols:
DDIT3
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DDIT3/CHOP (NP_0040742)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG