PIPA588135
Caspase 8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA588135-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA588135 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
Caspase 8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Casp8
Gene Alias
ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12370, 64044, 841
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.43 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
O89110, Q14790, Q9JHX4
Gene Symbols
Casp8
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Caspase-8 (NP_2035191)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: QLMDHSNMDC FICCILSHGD KGIIYGTDGQ EAPIYELTSQ FTGLKCPSLA GKPKVFFIQA CQGDNYQKGI PVETDSEEQP YLEMDLSSPQ TRYIPDEADF L Positive Samples: Raji, HL-60; Cellular Location: Cytoplasm Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family
- Sequential activation of caspases play a central role in the execution-phase of cell apoptosis
- Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit
- Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits
- Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli
- The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD
- Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases
- Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the pro-form of the Caspase 8 protein
- Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby committing the cell to undergo apoptosis
- In addition, Caspase 8 also reacts with Jurkat cells and Tonsil
- Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family
- Many alternatively spliced transcript variants encoding different isoforms have been described for Caspase 8, however, not all variants have had their full-length sequences determined.
Compare Similar Items
Show Difference
Antigen: Caspase 8
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Casp8
Gene Alias: ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12370, 64044, 841
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.43 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: O89110, Q14790, Q9JHX4
Gene Symbols: Casp8
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Caspase-8 (NP_2035191)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Caspase 8
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Casp8
Gene Alias:
ALPS2B, apoptosis-related cysteine peptidase, apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP8, CASP-8, caspase 8, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, Caspase8, caspase-8, Caspase-8 precursor, Caspase-8 subunit p10, Caspase-8 subunit p18, EC 3.4.22.61, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, Fas-linked ICE-like protease, FLICE, FLJ17672, ICE8, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MCH5, MGC78473, MORT1-associated ced-3 homolog, OTTHUMP00000163720, OTTHUMP00000165063, OTTHUMP00000206557, OTTHUMP00000206581
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12370, 64044, 841
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.43 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
O89110, Q14790, Q9JHX4
Gene Symbols:
Casp8
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Caspase-8 (NP_2035191)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: LDHA
Classification: Polyclonal
Conjugate: Unconjugated
Gene: LDHA
Gene Alias: Cell proliferation-inducing gene 19 protein, epididymis secretory sperm binding protein Li 133P, GSD11, HEL-S-133P, l7R2, Lactate Dehydrogenase, lactate dehydrogenase 1, A chain, lactate dehydrogenase 3, C chain, sperm specific, lactate dehydrogenase A, lactate dehydrogenase A4, lactate dehydrogenase A-like, lactate dehydrogenase C, lactate dehydrogenase C variant 3, lactate dehydrogenase M, lactate dehydrogenase-A, lactate dehydrogenase-M, lactate dehydrogenase-M (EC 1.1.1.27), Lactic Dehydrogenase, LDH, LDH muscle subunit, LDH testis subunit, Ldh1, Ldh-1, Ldh3, Ldha, LDH-A, ldha protein, ldha1, LDH-A4 muscle-specific isozyme, glycolytic enzyme, Ldhc, LDH-C, Ldhm, LDH-M, LDH-X, L-lactate dehydrogenase, L-lactate dehydrogenase A chain, L-lactate dehydrogenase C chain, M-LDH, OTTHUMP00000165206, PIG19, proliferation-inducing gene 19, renal carcinoma antigen NY-REN-59
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16828, 24533, 29634, 3939
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration: 0.63 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: P00338, P04642, P06151, P19629
Gene Symbols: LDHA
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-332 of human LDHA (NP_0055571)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
LDHA
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
LDHA
Gene Alias:
Cell proliferation-inducing gene 19 protein, epididymis secretory sperm binding protein Li 133P, GSD11, HEL-S-133P, l7R2, Lactate Dehydrogenase, lactate dehydrogenase 1, A chain, lactate dehydrogenase 3, C chain, sperm specific, lactate dehydrogenase A, lactate dehydrogenase A4, lactate dehydrogenase A-like, lactate dehydrogenase C, lactate dehydrogenase C variant 3, lactate dehydrogenase M, lactate dehydrogenase-A, lactate dehydrogenase-M, lactate dehydrogenase-M (EC 1.1.1.27), Lactic Dehydrogenase, LDH, LDH muscle subunit, LDH testis subunit, Ldh1, Ldh-1, Ldh3, Ldha, LDH-A, ldha protein, ldha1, LDH-A4 muscle-specific isozyme, glycolytic enzyme, Ldhc, LDH-C, Ldhm, LDH-M, LDH-X, L-lactate dehydrogenase, L-lactate dehydrogenase A chain, L-lactate dehydrogenase C chain, M-LDH, OTTHUMP00000165206, PIG19, proliferation-inducing gene 19, renal carcinoma antigen NY-REN-59
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16828, 24533, 29634, 3939
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration:
0.63 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
P00338, P04642, P06151, P19629
Gene Symbols:
LDHA
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-332 of human LDHA (NP_0055571)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: NeuroD1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: NEUROD1
Gene Alias: Basic helix-loop-helix factor 1, basic helix-loop-helix transcription factor, Beta2, beta-cell E-box transactivator 2, beta-cell E-box transcriptional activator 2, BHF1, BHF-1, bHLHa3, Class A basic helix-loop-helix protein 3, MODY6, neuro d1, Neurod, Neurod1, neurogenic differentiation 1, neurogenic differentiation factor 1, neurogenic helix-loop-helix protein NEUROD, neuronal differentiation 1
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 29458, 4760
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Western Blot
Concentration: 1.44 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: Q13562, Q64289
Gene Symbols: NEUROD1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 160-356 of human NEUROD1 (NP_0024912)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
NeuroD1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
NEUROD1
Gene Alias:
Basic helix-loop-helix factor 1, basic helix-loop-helix transcription factor, Beta2, beta-cell E-box transactivator 2, beta-cell E-box transcriptional activator 2, BHF1, BHF-1, bHLHa3, Class A basic helix-loop-helix protein 3, MODY6, neuro d1, Neurod, Neurod1, neurogenic differentiation 1, neurogenic differentiation factor 1, neurogenic helix-loop-helix protein NEUROD, neuronal differentiation 1
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
29458, 4760
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Western Blot
Concentration:
1.44 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
Q13562, Q64289
Gene Symbols:
NEUROD1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 160-356 of human NEUROD1 (NP_0024912)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: SQSTM1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Sqstm1
Gene Alias: A170, EBI3-associated protein of 60 kDa, EBI3-associated protein p60, EBIAP, FTDALS3, hypothetical protein 1, ORCA, OSF-6, Osi, OSIL, oxidative stress induced, oxidative stress induced like, p60, p62, p62B, PDB3, phosphotyrosine independent ligand for the Lck SH2 domain p62, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, PKC-zeta-interacting protein, protein kinase C-zeta-interacting protein, sb:cb621, Sequestosome 1, sequestosome-1, Sqstm1, STAP, STONE14, ubiquitin-binding protein p62, Unknown (protein for MGC:127197), zgc:85784, ZIP, ZIP3
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 113894, 18412, 8878
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 0.49 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: O08623, Q13501, Q64337
Gene Symbols: Sqstm1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-356 of human SQSTM1/p62 (NP_0011357701)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
SQSTM1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Sqstm1
Gene Alias:
A170, EBI3-associated protein of 60 kDa, EBI3-associated protein p60, EBIAP, FTDALS3, hypothetical protein 1, ORCA, OSF-6, Osi, OSIL, oxidative stress induced, oxidative stress induced like, p60, p62, p62B, PDB3, phosphotyrosine independent ligand for the Lck SH2 domain p62, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, PKC-zeta-interacting protein, protein kinase C-zeta-interacting protein, sb:cb621, Sequestosome 1, sequestosome-1, Sqstm1, STAP, STONE14, ubiquitin-binding protein p62, Unknown (protein for MGC:127197), zgc:85784, ZIP, ZIP3
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
113894, 18412, 8878
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
0.49 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
O08623, Q13501, Q64337
Gene Symbols:
Sqstm1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-356 of human SQSTM1/p62 (NP_0011357701)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG