PIPA595372
CD273 (B7-DC) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595372-Each-of-1 | In Stock | ₹ 44,705.10 |
PIPA595372 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,705.10
GST (18%): ₹ 8,046.918
Total Price: ₹ 52,752.018
Antigen
CD273 (B7-DC)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PDCD1LG2
Gene Alias
B7 dendritic cell molecule, B7DC, B7-DC, bA574F11.2, Btdc, Butyrophilin B7-DC, butyrophilin-like protein, CD273, F730015O22Rik, MGC124039, MGC124040, PD1 ligand 2, PD-1 ligand 2, PD-1-ligand 2, PDCD1 ligand 2, PDCD1L2, Pdcd1lg2, Pdl2, PD-L2, Programmed cell death 1 ligand 2, programmed death ligand 2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
80380
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Lyophilized
Applications
Western Blot
Concentration
500 μg/mL
Formulation
PBS with 5MG BSA and 0.05MG sodium azide
Gene Accession No.
Q9BQ51
Gene Symbols
PDCD1LG2
Immunogen
E.coli-derived human B7 DC recombinant protein (Position: L20-T220).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Human B7 DC shares 72.1% amino acid (aa) sequence identity with mouse B7 DC
- Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL
- Programmed death-ligand 2 (PD-L2), or B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily that, along with programmed death-ligand 1 (PD-L1), acts as a ligand for programmed cell death protein 1 (PD-1)
- Though expressed primarily in dendritic cells, PD-L2 expression can be induced on a wide variety of immune and non-immune cells depending on the microenvironment
- PD-L2 expression is particularly upregulated in the presence of Th2 cytokine, IL-4, as well as Th1 cytokines, TNF-alpha and IFN-gamma to a lesser degree
- While generally expressed at lower levels compared to PD-L1, PD-L2 demonstrates a 2 to 6 times higher relative affinity to PD-1 than PD-L1
- PD-1 and its ligands are referred to as inhibitory immune checkpoint molecules in that they provide useful negative feedback during physiological homeostasis
- Ligation of PD-L2 or PD-L1 inhibits activation, proliferation, and cytokine secretion (e.g
- IFN-gamma, IL-10) in T cells, μgtimately dampening immune response
- Conversely, studies have shown that PD-L2 can also stimulate T cell proliferation and cytokine production, even in PD-1-deficient T cells, suggesting additional receptors
- Recent studies have concluded that PD-L2 also binds to a second receptor, repulsive guidance molecule b (RGMb), which was originally identified as a receptor for bone morphogenetic proteins (BMPs)
- RGMb is expressed in the central nervous system, as well as in macrophages, however, its role in immunity is only beginning to emerge
- Interaction between PD-L2 and RGMb regulates the development of respiratory tolerance in the lung through BMP and/or neogenin signaling pathways
- The naturally occurring human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.
Compare Similar Items
Show Difference
Antigen: CD273 (B7-DC)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PDCD1LG2
Gene Alias: B7 dendritic cell molecule, B7DC, B7-DC, bA574F11.2, Btdc, Butyrophilin B7-DC, butyrophilin-like protein, CD273, F730015O22Rik, MGC124039, MGC124040, PD1 ligand 2, PD-1 ligand 2, PD-1-ligand 2, PDCD1 ligand 2, PDCD1L2, Pdcd1lg2, Pdl2, PD-L2, Programmed cell death 1 ligand 2, programmed death ligand 2
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 80380
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 5MG BSA and 0.05MG sodium azide
Gene Accession No.: Q9BQ51
Gene Symbols: PDCD1LG2
Immunogen: E.coli-derived human B7 DC recombinant protein (Position: L20-T220).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
CD273 (B7-DC)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PDCD1LG2
Gene Alias:
B7 dendritic cell molecule, B7DC, B7-DC, bA574F11.2, Btdc, Butyrophilin B7-DC, butyrophilin-like protein, CD273, F730015O22Rik, MGC124039, MGC124040, PD1 ligand 2, PD-1 ligand 2, PD-1-ligand 2, PDCD1 ligand 2, PDCD1L2, Pdcd1lg2, Pdl2, PD-L2, Programmed cell death 1 ligand 2, programmed death ligand 2
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
80380
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 5MG BSA and 0.05MG sodium azide
Gene Accession No.:
Q9BQ51
Gene Symbols:
PDCD1LG2
Immunogen:
E.coli-derived human B7 DC recombinant protein (Position: L20-T220).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: VAMP7
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Vamp7
Gene Alias: Sybl1, synaptobrevin-like 1, synaptobrevin-like protein 1, tetanus neurotoxin-insensitive VAMP, tetanus-insensitive VAMP, TIVAMP, Ti-VAMP, vamp, Vamp7, VAMP-7, vesicle associated membrane protein 7, vesicle-associated membrane protein 7
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6845, 85491
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 5MG BSA and 0.05MG sodium azide
Gene Accession No.: P51809, Q9JHW5
Gene Symbols: Vamp7
Immunogen: E.coli-derived human SYBL1 recombinant protein (Position: N24-T190).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
VAMP7
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Vamp7
Gene Alias:
Sybl1, synaptobrevin-like 1, synaptobrevin-like protein 1, tetanus neurotoxin-insensitive VAMP, tetanus-insensitive VAMP, TIVAMP, Ti-VAMP, vamp, Vamp7, VAMP-7, vesicle associated membrane protein 7, vesicle-associated membrane protein 7
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6845, 85491
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 5MG BSA and 0.05MG sodium azide
Gene Accession No.:
P51809, Q9JHW5
Gene Symbols:
Vamp7
Immunogen:
E.coli-derived human SYBL1 recombinant protein (Position: N24-T190).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: ACVR2A
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ACVR2A
Gene Alias: activin A receptor type 2A, activin A receptor type IIA, activin A receptor, type IIA, activin receptor IIA, activin receptor type IIA, Activin receptor type-2A, Actrii, ActrIIa, ACTR-IIA, ACVR2, Acvr2a, rActR-II, TactrII, type II activin receptor
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11480, 29263, 92
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 5MG BSA and 0.05MG sodium azide
Gene Accession No.: P27037, P27038, P38444
Gene Symbols: ACVR2A
Immunogen: E.coli-derived human ACVR2A recombinant protein (Position: Q421-L513).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
ACVR2A
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ACVR2A
Gene Alias:
activin A receptor type 2A, activin A receptor type IIA, activin A receptor, type IIA, activin receptor IIA, activin receptor type IIA, Activin receptor type-2A, Actrii, ActrIIa, ACTR-IIA, ACVR2, Acvr2a, rActR-II, TactrII, type II activin receptor
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11480, 29263, 92
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 5MG BSA and 0.05MG sodium azide
Gene Accession No.:
P27037, P27038, P38444
Gene Symbols:
ACVR2A
Immunogen:
E.coli-derived human ACVR2A recombinant protein (Position: Q421-L513).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: APC2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: APC2
Gene Alias: 9230107K09Rik, adenomatosis polyposis coli 2, adenomatous polyposis coli like, adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like, AI852447, AL024279, Anapc2, anaphase promoting complex subunit 2, anaphase-promoting complex subunit 2, APC2, APC2, WNT signaling pathway regulator, APCL, APC-like, Cyclosome subunit 2, EGK_07151, Emi4, expressed during mesenchymal induction 4, Imi4, induced during mesenchymal induction 4, KIAA1406, mKIAA1406, R75424
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10297
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Lyophilized
Applications: Western Blot
Concentration: 500 μg/mL
Formulation: PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.: O95996
Gene Symbols: APC2
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human APC2 (51-90aa KHLQGKLEQEARVLVSSGQTEVLEQLKALQMDITSLYNLK).
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
APC2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
APC2
Gene Alias:
9230107K09Rik, adenomatosis polyposis coli 2, adenomatous polyposis coli like, adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like, AI852447, AL024279, Anapc2, anaphase promoting complex subunit 2, anaphase-promoting complex subunit 2, APC2, APC2, WNT signaling pathway regulator, APCL, APC-like, Cyclosome subunit 2, EGK_07151, Emi4, expressed during mesenchymal induction 4, Imi4, induced during mesenchymal induction 4, KIAA1406, mKIAA1406, R75424
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10297
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Lyophilized
Applications:
Western Blot
Concentration:
500 μg/mL
Formulation:
PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.:
O95996
Gene Symbols:
APC2
Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human APC2 (51-90aa KHLQGKLEQEARVLVSSGQTEVLEQLKALQMDITSLYNLK).
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG