Epredia™ Lab Vision™ Pax-5 Rabbit Monoclonal Antibody

Description

• Description PAX-5 is a B-cell-specific activator protein (BSAP)
• In the early stages of B cell developmemt, PAX-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20
• PAX-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells
• PAX-5 is expressed in most B-cell malignancies (pre-B and mature B cell lymphomas/leukemias)
• Over 90% of cases are positive for PAX-5 in Hodgkin's lymphoma, lymphoplasmacytic lymphoma, Merkel cell and small cell carcinoma
• T-cell lymphomas, myeloma/plasmacytoma and carcinoid tumors are negative for PAX-5
• Host Species: Rabbit Clone: SP34 Isotype: IgG Species Reactivity: Human
• Others not tested
• Immunogen: Synthetic peptide derived from the C-terminus of human PAX-5 protein Molecular Weight: 50kDa Positive Control: Tonsil Cellular Localization: Nuclear Recommended for: Immunohistochemistry (Formalin/paraffin)