773069

Fmoc-N-Me-Cys(Trt)-OH

97% (HPLC)

Manufacturer: Sigma Aldrich

CAS Number: 944797-51-7

Synonym(S): N-α-Fmoc-N-α-methyl-S-trityl-L-cysteine

Select a Size

Pack Size SKU Availability Price
1 G 773069-1-G In Stock ₹ 44,414.98

773069 - 1 G

₹ 44,414.98

In Stock

Quantity

1

Base Price: ₹ 44,414.98

GST (18%): ₹ 7,994.696

Total Price: ₹ 52,409.676

Quality Level

100

Assay

97% (HPLC)

form

powder or crystals

optical activity

[α]22/D -25.0°, c = 0.5% in dichloromethane

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

mp

234-239 °C

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-8°C

InChI

1S/C38H33NO4S/c1-39(37(42)43-25-34-32-23-13-11-21-30(32)31-22-12-14-24-33(31)34)35(36(40)41)26-44-38(27-15-5-2-6-16-27,28-17-7-3-8-18-28)29-19-9-4-10-20-29/h2-24,34-35H,25-26H2,1H3,(H,40,41)/t35-/m0/s1

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Description

  • Application: Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine). It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A.[1]

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Show Difference

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Sigma Aldrich

773069

97% (HPLC)...


Quality Level:
100

Assay:
97% (HPLC)

form:
powder or crystals

optical activity:
[α]22/D -25.0°, c = 0.5% in dichloromethane

reaction suitability:
reaction type: Fmoc solid-phase peptide synthesis

mp:
234-239 °C

application(s):
peptide synthesis

functional group:
Fmoc

storage temp.:
2-8°C

InChI:
1S/C38H33NO4S/c1-39(37(42)43-25-34-32-23-13-11-21-30(32)31-22-12-14-24-33(31)34)35(36(40)41)26-44-38(27-15-5-2-6-16-27,28-17-7-3-8-18-28)29-19-9-4-10-20-29/h2-24,34-35H,25-26H2,1H3,(H,40,41)/t35-/m0/s1

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Sigma Aldrich

773077

97%, for peptide synthesis...


Quality Level:
100

Assay:
97%

form:
powder or crystals

optical activity:
[α]22/D -39.0°, c = 0.5% in DMF

reaction suitability:
reaction type: Fmoc solid-phase peptide synthesis

mp:
135-140 °C

application(s):
peptide synthesis

functional group:
Fmoc

storage temp.:
2-8°C

InChI:
__

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Sigma Aldrich

77310

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Quality Level:
200

Assay:
≥99.0% (RT)

form:
powder or crystals

optical activity:
__

reaction suitability:
__

mp:
122 °C (lit.)

application(s):
__

functional group:
__

storage temp.:
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InChI:
__

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Sigma Aldrich

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Assay:
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form:
powder or crystals

optical activity:
[α]22/D -14.0°, c = 1% in chloroform

reaction suitability:
reaction type: Fmoc solid-phase peptide synthesis

mp:
189-194 °C (decomposition)

application(s):
peptide synthesis

functional group:
BocFmoc

storage temp.:
2-8°C

InChI:
1S/C27H34N2O6/c1-27(2,3)35-25(32)28-16-10-9-15-23(24(30)31)29(4)26(33)34-17-22-20-13-7-5-11-18(20)19-12-6-8-14-21(19)22/h5-8,11-14,22-23H,9-10,15-17H2,1-4H3,(H,28,32)(H,30,31)/t23-/m0/s1