17-931

Tocris Bioscience™ AF 12198

Manufacturer: Tocris Bioscience™

Select a Size

Pack Size SKU Availability Price
Each of 1 17-931-Each-of-1 In Stock ₹ 44,320.08

17-931 - Each of 1

₹ 44,320.08

In Stock

Quantity

1

Base Price: ₹ 44,320.08

GST (18%): ₹ 7,977.614

Total Price: ₹ 52,297.694

Purity

0.95

Content And Storage

Store at -20°C

Quantity

1 mg

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Description

  • AF 12198 is a potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC50 values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively)
  • Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1β induction of IL-8 in human dermal fibroblasts
  • Reduces IL-1β-induced IL-6 production and exhibits anti-inflammatory activity in vivo .

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