HS 014 is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively)
Increases food intake in rats and nociception in mice following central administration in vivo
Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.
• ElectroMAX DH12S Cells (5 x 100 μL)• pUC19 DNA (50 μL at 10 pg/μL)• M13KO7 Helper Phage (2 x 1 mL)Store at –80°C.• S.O.C. Medium (2 x 6 mL)Store S.O.C. Medium at 4°C or room temperature.