7388100U
Tocris Bioscience™ ND1-YL2
Manufacturer: Tocris Bioscience™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 7388100U-Each-of-1 | In Stock | ₹ 56,640.72 |
7388100U - Each of 1
In Stock
Quantity
1
Base Price: ₹ 56,640.72
GST (18%): ₹ 10,195.33
Total Price: ₹ 66,836.05
Purity
95%
Content And Storage
Store at -20°C
Molecular Weight (g/mol)
M.W.-observed: 2385.93
Quantity
100 μg
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Description
- ND1-YL2 is a peptide-based PROTAC™ Degrader of steroid receptor co-activator 1 (SRC-1; also known as nuclear receptor coactivator 1, NCOA1)
- ND1-YL2 is composed of a stapled peptide that binds SRC-1 (YL2) joined by a linker to a tetrapeptide that binds UBR box domains
- Upon ternary complex formation, SRC-1 is polyubiquitinated and subsequently degraded via the N-degron pathway
- This Degrader induces dose-dependent degradation of SRC-1 in the MDA-MB-231 triple negative breast cancer cell line (DC50 = 10 μM), and binds to the PAS-B domain of SRC-1 (Ki = 320 nM)
- ND1-YL2 inhibits MDA-MB-231 cell migration in vitro , and suppresses metastasis of MDA-MB-231 cells in vivo
- PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license .
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Purity: 95%
Content And Storage: Store at -20°C
Molecular Weight (g/mol): M.W.-observed: 2385.93
Quantity: 100 μg
Purity:
95%
Content And Storage:
Store at -20°C
Molecular Weight (g/mol):
M.W.-observed: 2385.93
Quantity:
100 μg
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