Invitrogen™ CellROX™ Orange Reagent, for oxidative stress detection

Description

• CellROX™ Orange Reagent is a novel fluorogenic probe for measuring oxidative stress in live cells
• This cell-permeant dye is non-fluorescent while in a reduced state and exhibits bright orange fluorescence upon oxidation by reactive oxygen species (ROS), with absorption/emission maxima of ∼545/565 nm
• While this reagent is not formaldehyde-fixable, it can be multiplexed with other live cell-compatible probes such as GFP, CellEvent™ Caspase 3/7 Green reagent, Image-iT™ DEAD Green, Green and Deep Red MitoTracker™ dyes, and NucBlue™ reagent
• CellROX™ Orange Reagent is compatible with various platforms, such as traditional fluorescence microscopy, high content screening (HCS), and flow cytometery
• This reagent is also compatible with the Tali™ Image-based Cytometer
• In addition, CellROX™ Orange Reagent is: • Compatible with other live cell probes, including GFP, and may be added directly to serum-containing growth media • Provided as a stable, ready-to-use DMSO solution with a simple protocol compatible with standard workflows in fluorescence microscopy • Provided as five single-use vials containing enough total reagent for five 96-well plates or 100 coverslips Oxidative stress results from an imbalance between the production of reactive oxygen species (ROS) and the ability of cells to scavenge them
• ROS play an important role in the progression of several diseases, including inflammation, atherosclerosis, aging, and age-related degenerative disorders
• For Research Use Only
• Not intended for any animal or human therapeutic or diagnostic use
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