IL-3 human

Description

• General description: IL3 (interleukin 3) is a haematopoietic growth factor, the gene for which is localized to human chromosome locus 5.[1] Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.
• Biochem/physiol Actions: IL3 (interleukin 3) promotes the survival, proliferation and differentiation of haematopoietic progenitor cells. It also functions as an activator of basophils thus, resulting in significant increase in antigen and IgE-mediated release of cytokines and other mediators. Certain variants in this gene confer protection against malaria attack, and thus, this gene might play a role in the pathophysiology of falciparum malaria.[1] SNP (single nucleotide polymorphism) rs40401 in this gene and smoking have a positive correlation with asthma in Japanese women.[2] IL3 is involved in brain development and has a direct influence on the proliferation and survival of neural progenitor cell population, thereby also controlling human brain volume.[3]
• Sequence: APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF
• Physical form: Lyophilized with no additives.
• Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.