SRP3178
TPO human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Manufacturer: Sigma Aldrich
Synonym(S): MGDF, Megakaryocyte colony-stimulating factor, Thrombopoietin, c-MPL Ligand
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 μG | SRP3178-10-μG | In Stock | ₹ 43,989.30 |
SRP3178 - 10 μG
In Stock
Quantity
1
Base Price: ₹ 43,989.30
GST (18%): ₹ 7,918.074
Total Price: ₹ 51,907.374
biological source
human
recombinant
expressed in E. coli
Assay
≥98% (HPLC)≥98% (SDS-PAGE)
form
lyophilized
potency
≤1.0 ng/mL ED50
mol wt
18.6 kDa
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white
Related Products
Description
- General description: Thrombopoietin (TPO) is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle.[1] It is an acidic glycoprotein. The gene encoding it is localized on human chromosome 3q27.1.[2][3] Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6kDa), which contains the erythropoietin-like domain of the full length TPO protein.
- Biochem/physiol Actions: Thrombopoietin (TPO) stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the cellular proto-oncogene (c-mpl) receptor and acts as an important regulator of circulating platelets. High levels of TPO have been observed in patients with aplastic anemia.[3] Human and murine TPO exhibits cross-species reactivity.
- Sequence: SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL
- Physical form: Lyophilized from 0.1% TFA.
- Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
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biological source: human
recombinant: expressed in E. coli
Assay: ≥98% (HPLC)≥98% (SDS-PAGE)
form: lyophilized
potency: ≤1.0 ng/mL ED50
mol wt: 18.6 kDa
packaging: pkg of 10 μg
technique(s): cell culture | mammalian: suitable
impurities: <0.1 EU/μg endotoxin, tested
color: white
biological source:
human
recombinant:
expressed in E. coli
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
potency:
≤1.0 ng/mL ED50
mol wt:
18.6 kDa
packaging:
pkg of 10 μg
technique(s):
cell culture | mammalian: suitable
impurities:
<0.1 EU/μg endotoxin, tested
color:
white
biological source: human
recombinant: expressed in HEK 293 cells
Assay: ≥98% (HPLC)≥98% (SDS-PAGE)
form: lyophilized
potency: 0.8-1.0 μg/mL ED50
mol wt: 74.1 kDa
packaging: pkg of 50 μg
technique(s): cell culture | mammalian: suitable
impurities: <0.1 EU/μg endotoxin, tested
color: white
biological source:
human
recombinant:
expressed in HEK 293 cells
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
potency:
0.8-1.0 μg/mL ED50
mol wt:
74.1 kDa
packaging:
pkg of 50 μg
technique(s):
cell culture | mammalian: suitable
impurities:
<0.1 EU/μg endotoxin, tested
color:
white
biological source: human
recombinant: expressed in E. coli
Assay: ≥98% (HPLC)≥98% (SDS-PAGE)
form: lyophilized
potency: 1.0-8.0 ng/mL
mol wt: 38.2 kDa
packaging: pkg of 10 μg
technique(s): cell culture | mammalian: suitable
impurities: <0.1 EU/μg endotoxin, tested
color: white
biological source:
human
recombinant:
expressed in E. coli
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
potency:
1.0-8.0 ng/mL
mol wt:
38.2 kDa
packaging:
pkg of 10 μg
technique(s):
cell culture | mammalian: suitable
impurities:
<0.1 EU/μg endotoxin, tested
color:
white
biological source: human
recombinant: expressed in E. coli
Assay: ≥98% (HPLC)≥98% (SDS-PAGE)
form: lyophilized
potency: 1.0-2.0 μg/mL ED50
mol wt: 38.0 kDa
packaging: pkg of 20 μg
technique(s): cell culture | mammalian: suitable
impurities: <0.1 EU/μg endotoxin, tested
color: white
biological source:
human
recombinant:
expressed in E. coli
Assay:
≥98% (HPLC)≥98% (SDS-PAGE)
form:
lyophilized
potency:
1.0-2.0 μg/mL ED50
mol wt:
38.0 kDa
packaging:
pkg of 20 μg
technique(s):
cell culture | mammalian: suitable
impurities:
<0.1 EU/μg endotoxin, tested
color:
white