Description

• General description: Chemical structure: aminoglycoside
• Application: Spectinomycin dihydrochloride pentahydrate has been used as a supplement in different types of media.[3][4]
• Biochem/physiol Actions: Mode of Action: Spectinomycin acts by inhibiting protein synthesis and elongation by binding to the bacterial 30S ribosomal subunit and interfering with peptidyl tRNA translocation.Mode of Resistance: A mutation in rpsE, the gene for ribosomal protein S5, prevents the binding of spectinomycin. Resistance is also conferred by the aminoglycoside-3′-adenyltransferase gene (aadA). Antimicrobial spectrum: Spectinomycin acts against gram-negative and gram-positive bacteria.
• Caution: Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.
• Preparation Note: Stock solutions should be prepared at 10 mg/mL in water and filter sterilized.
• Other Notes: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.