Description

• Application: Smartphone-based Ellman′s colourimetric methods for the analysis of d-penicillamine formulation and thiolated polymer: Demonstrates the application of L-Cysteine hydrochloride monohydrate in developing colorimetric assays for pharmaceutical analysis, enhancing the accessibility and cost-effectiveness of drug quality control (Phadungcharoen et al., 2019). The effects of the thiolation with thioglycolic acid and l-cysteine on the mucoadhesion properties of the starch-graft-poly(acrylic acid): Focuses on the modification of polymers with L-Cysteine hydrochloride monohydrate to improve their mucoadhesive properties, which is critical for developing more effective drug delivery systems (Gök et al., 2017).On-line pre-reduction of pentavalent arsenicals by thioglycolic acid for speciation analysis by selective hydride generation-cryotrapping-atomic absorption spectrometry: Utilizes L-Cysteine hydrochloride monohydrate in analytical chemistry techniques to improve the detection and measurement of toxic elements in environmental samples, crucial for monitoring and ensuring public health (Musil et al., 2008).
• Biochem/physiol Actions: NMDA glutamatergic receptor antagonist.
• Analysis Note: Assay (alkalimetric, calculated on dried substance): 98.5 - 101.0 %Identity (IR-spectrum): passes testIdentity (Chloride): passes testAppearance: white or almost white, crystalline powder or colorless crystalsAppearance of solution (25 g/l, water): clear and not more intense in color than reference solution BY6Spec. rotation (α 20/D, 80 g/l, hydrochloric acid 250 g/l, calc. on dried substance): +5.5 to +7.0Spec. rotation (α 25/D, 80 g/l, hydrochloric acid 6 mol/l, calc. on dried substance): +5.7 to +6.8Sulfate (SO₄): ≤ 300 ppmHeavy metals (as Pb): ≤ 10 ppmFe (Iron): ≤ 20 ppmRelated Compounds, total (TLC): ≤ 0.5 %Ninhydrin-positive substances (LC)(impurity A (570 nm)): ≤ 0.5 %Ninhydrin-positive substances (LC)(any ninhydrin-positive impurity): ≤ 0.2 %Ninhydrin-positive substances (LC) (ammonium (570 nm)): ≤ 0.02 %Ninhydrin-positive substances (LC)(total impurities): ≤ 1.0 %Residual solvents (ICH Q3C): excluded by manufacturing processSulfated ash (600 °C): ≤ 0.1 %Loss on drying (Vacuum < 0.7 kPa, P₂O₅, 24 h): 8.0 - 12.0 %Bacterial endotoxins: ≤ 6.0 I.U./g