554720
trans-Retinoic Acid
Potent modulator of growth and differentiation. Inhibits melanocyte adhesion, motility, and growth.
Manufacturer: Millipore
CAS Number: 302-79-4
Synonym(S): trans-Retinoic Acid, Tretinoin, ATRA, Vitamin A Acid
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 500 MG | 554720-500-MG | In Stock | ₹ 19,550.00 |
554720 - 500 MG
In Stock
Quantity
1
Base Price: ₹ 19,550.00
GST (18%): ₹ 3,519.00
Total Price: ₹ 23,069.00
Quality Level
100
Assay
≥95% (by assay)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freezedesiccated (hygroscopic)protect from light
color
yellow
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
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Description
- General description: Potent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells.
- Application: All-trans-retinoic acid modulates glycolysis via H19 and telomerase: the role of mir-let-7a in estrogen receptor-positive breast cancer cells.: This research reveals how all-trans-retinoic acid influences glycolysis in breast cancer cells by modulating H19 and telomerase, demonstrating its potential in breast cancer therapy (El Habre et al., 2024). Retinoic acid tiers mitochondrial metabolism to Sertoli Cell-Mediated efferocytosis via a non-RAR-dependent mechanism.: The study explores the role of retinoic acid in linking mitochondrial metabolism to efferocytosis in Sertoli cells, providing insights into its non-RAR-dependent mechanisms and potential applications in reproductive biology (Wu et al., 2024). Combined treatment of All-trans retinoic acid with Tamoxifen suppresses ovarian cancer.: This article discusses the synergistic effects of combining all-trans-retinoic acid with tamoxifen in suppressing ovarian cancer, highlighting a promising therapeutic strategy for ovarian cancer patients (Xu et al., 2024).
- Packaging: Packaged under inert gas
- Warning: Toxicity: Harmful & Carcinogenic / Teratogenic (E)
- Reconstitution: Following reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 2 weeks at 4°C.
- Other Notes: Tosi, P., et al. 1994. Leuk. Lymphoma14, 503.Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys.300, 684.Labbaye, C., et al. 1993. Blood81, 475.Sakashita, A., et al. 1993. Blood81, 1009.Situ, R., et al. 1993. Dermatology186, 38.Tini, M., et al. 1993. Genes Develop.7, 295.Leid, M., et al. 1992. Trends Biochem. Sci.17, 427.Sharpe, C.R. 1991. Neuron7, 239.Thaller, C. and Eichele, G. 1990. Nature345, 815.
- Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P202 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P313
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Show Difference
Quality Level: 100
Assay: ≥95% (by assay)
form: solid
manufacturer/tradename: Calbiochem®
storage condition: OK to freezedesiccated (hygroscopic)protect from light
color: yellow
solubility: DMSO: 25 mg/mL
shipped in: ambient
storage temp.: 2-8°C
InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Quality Level:
100
Assay:
≥95% (by assay)
form:
solid
manufacturer/tradename:
Calbiochem®
storage condition:
OK to freezedesiccated (hygroscopic)protect from light
color:
yellow
solubility:
DMSO: 25 mg/mL
shipped in:
ambient
storage temp.:
2-8°C
InChI:
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Quality Level: 100
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