A8851
Apicidin
≥98% (HPLC), from microbial
Manufacturer: Sigma Aldrich
CAS Number: 183506-66-3
Synonym(S): Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | A8851-1-MG | In Stock | ₹ 15,804.50 |
| 5 MG | A8851-5-MG | In Stock | ₹ 51,018.23 |
A8851 - 1 MG
In Stock
Quantity
1
Base Price: ₹ 15,804.50
GST (18%): ₹ 2,844.81
Total Price: ₹ 18,649.31
biological source
microbial
Quality Level
200
sterility
non-sterile
Assay
≥98% (HPLC)
form
solid
solubility
DMSO: ~1 mg/mL
antibiotic activity spectrum
parasites
Mode of action
enzyme | inhibits
shipped in
wet ice
storage temp.
−20°C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Medchemexpress LLC HY-N6735 1mg Medchemexpress, Apicidin CAS:183506-66-3 Purity:>98% | -- | ₹ 9,345.00 | ||
eMolecules Medchem Express / Apicidin / 1mg / 523883521 / HY-N6735 / / 183506-66-3 / [null] / 623.795 / C34H49N5O6 | -- | ₹ 13,100.80 | ||
Sigma Aldrich Fine Chemicals Biosciences Apicidin | 183506-66-3 | MFCD03452661 | 1mg | -- | ₹ 15,045.45 | ||
Cayman Chemical Apicidin, 183506-66-3, 1 mg | -- | ₹ 6,141.00 | ||
Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl] | -- | ₹ 64,970.00 - ₹ 1,64,828.00 | ||
183506-66-3 | Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl] | -- | ₹ 4,806.00 - ₹ 34,443.00 |
Related Products
Description
- General description: Apicidin is a cyclic tetrapeptide fungal metabolite.[1][2]
- Application: Apicidin has been used as a histone deacetylase 2 (HDAC2) inhibitor to study its effects on 5-lipoxygenase (5-LO) mRNA expression in cell lines of Mono Mac6.[3] It has also been used to study the effects of toll-like receptor 8 (TLR-8) stimulation and histone modification on the expression of an activator protein 1 [AP-1] family member(Fra-2) and tissue inhibitor of metalloproteinases 1 (TIMP-1) in monocytes.[4]
- Biochem/physiol Actions: Apicidin is a potent inhibitor of histone deacetylase (HDAC). It particularlyinhibits histone deacetylase 1 and 3 (HDAC1 and HDAC3).[5] Apicidin exhibits anti-protozoal activity against apicomplexan metabolite produced by parasites.[1] It also possesses anti-proliferative activity against several cancer cell lines. Apicidin shows anti-cancer activity against human acute promyelocytic leukemia cell.[5]
- Features and Benefits: This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves