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C1511

Colistin sodium methanesulfonate

~11,500 U/mg

Manufacturer: Sigma Aldrich

CAS Number: 8068-28-8

Synonym(S): Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate

Select a Size

Pack Size SKU Availability Price
10000000 UNITS C1511-10000000-UNITS In Stock ₹ 20,729.88
100000000 UNITS C1511-100000000-UNITS In Stock ₹ 1,28,947.40

C1511 - 10000000 UNITS

₹ 20,729.88

In Stock

Quantity

1

Base Price: ₹ 20,729.88

GST (18%): ₹ 3,731.378

Total Price: ₹ 24,461.258

form

powder

Quality Level

200

specific activity

~11,500 U/mg

solubility

H2O: 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria

Mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

[Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)O

InChI

1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+;;;;;;;;;;/m1........../s1

InChI key

WSDSONZFNWDYGZ-BKFDUBCBSA-I

Other Options

Image Product Name Manufacturer Price Range
PHR1737
Colistimethate Sodium
Supelco ₹ 37,974.10
1147009
Colistimethate sodium
Sigma Aldrich ₹ 41,784.50
C2600000
Colistimethate sodium
Sigma Aldrich ₹ 14,267.35
Y0001888
Colistimethate sodium for peak identification
Sigma Aldrich ₹ 14,267.35
Y0001887
E1 Colistimethate sodium for peak identification
Sigma Aldrich ₹ 14,267.35
Y0001886
E2 Colistimethate sodium for peak identification
Sigma Aldrich ₹ 14,267.35
27655
Colistin sodium methanesulfonate
Sigma Aldrich ₹ 10,034.78 - ₹ 30,840.43

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Description

  • General description: Chemical structure: peptide
  • Application: Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination.
  • Biochem/physiol Actions: Colistin is a cationic, multicomponent lipopeptide antibiotic. It consists of a cyclic heptapeptide with tripeptide side chain, acylated at the N terminus by a fatty acid. It exhibits a potent anti-endotoxin.[1][2] Colistin interacts with the anionic LPS molecules and displaces calcium and magnesium ions. It solubilzes the cytoplasmic membrane resulting in leakage of cytosol which contributes to the bactericidal effect.[3][1]
  • Other Notes: Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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[Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)O
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1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+;;;;;;;;;;/m1........../s1
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WSDSONZFNWDYGZ-BKFDUBCBSA-I

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1S/C22H30Cl2N10.2C2H4O2/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*1-2(3)4/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H3,(H,3,4)
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WDRFFJWBUDTUCA-UHFFFAOYSA-N

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