D8809

Daunorubicin hydrochloride

meets USP testing specifications

Manufacturer: Sigma Aldrich

CAS Number: 23541-50-6

Synonym(S): Daunomycin hydrochloride

Select a Size

Pack Size SKU Availability Price
1 MG D8809-1-MG In Stock ₹ 4,730.53
10 MG D8809-10-MG In Stock ₹ 20,773.18

D8809 - 1 MG

₹ 4,730.53

In Stock

Quantity

1

Base Price: ₹ 4,730.53

GST (18%): ₹ 851.495

Total Price: ₹ 5,582.025

Agency

USP/NFmeets USP testing specifications

Quality Level

200

form

solid

antibiotic activity spectrum

neoplastics

Mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O

InChI

1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1

InChI key

GUGHGUXZJWAIAS-QQYBVWGSSA-N

Gene Information

human ... TOP2A(7153)

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Description

  • Biochem/physiol Actions: Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism.[1][2] Strong inhibitor of DNA and RNA synthesis.

SAFETY INFORMATION

Pictograms

GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H341,H351,H360FD

Precautionary Statements

P202 - P264 - P270 - P280 - P301 + P310 - P405

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Show Difference

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Sigma Aldrich

D8809

meets USP testing specifications...


Agency:
USP/NFmeets USP testing specifications

Quality Level:
200

form:
solid

antibiotic activity spectrum:
neoplastics

Mode of action:
DNA synthesis | interferes

storage temp.:
2-8°C

SMILES string:
Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O

InChI:
1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1

InChI key:
GUGHGUXZJWAIAS-QQYBVWGSSA-N

Gene Information:
human ... TOP2A(7153)

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1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

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