I4657

Insulin-like Growth Factor-I Receptor human

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Manufacturer: Sigma Aldrich

Synonym(S): IGF-I Receptor

Select a Size

Pack Size SKU Availability Price
50 μG I4657-50-μG In Stock ₹ 1,03,956.20

I4657 - 50 μG

₹ 1,03,956.20

In Stock

Quantity

1

Base Price: ₹ 1,03,956.20

GST (18%): ₹ 18,712.116

Total Price: ₹ 1,22,668.316

biological source

human

Quality Level

200

recombinant

expressed in NSO cells

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

mol wt

α-chain ~120 & 150 kDaβ subunit ~46 & 50 kDa

packaging

pkg of 50 μg

impurities

endotoxin, tested

UniProt accession no.

P08069

storage temp.

−20°C

Description

  • General description: IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase.[1] The gene is mapped to human chromosome 15q26.[2] It is expressed in various solid tumors as well as hematologic malignancies.[3]
  • Application: Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.[4]
  • Biochem/physiol Actions: IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
  • Physical form: Lyophilized from a 0.2 μm solution in phosphate buffered saline.
  • Analysis Note: As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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