Rapamycin
from Streptomyces hygroscopicus, ≥95% (HPLC), powder, mTOR inhibitor
Manufacturer: Sigma Aldrich
CAS Number: 53123-88-9
Synonym(S): 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, Sirolimus
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | R0395-1-MG | In Stock | ₹ 41,925.23 |
R0395 - 1 MG
In Stock
Quantity
1
Base Price: ₹ 41,925.23
GST (18%): ₹ 7,546.541
Total Price: ₹ 49,471.771
product name
Rapamycin from Streptomyces hygroscopicus, ≥95% (HPLC), powder
Quality Level
300
Assay
≥95% (HPLC)
form
powder
color
off-white
solubility
ethanol: 2 mMDMSO: soluble
antibiotic activity spectrum
fungiyeast
Mode of action
enzyme | inhibitsprotein synthesis | interferes
storage temp.
−20°C
SMILES string
CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
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Description
- General description: Chemical structure: macrolide
- Application: Rapamycin from Streptomyces hygroscopicus has been used: to treat BV2 cells or BV2-LC3 cells for autophagy assay[3]as an autophagy activator in the bone marrow mesenchymal stem cells (BM-MSCs) transfected with lentivirus carrier of small interfering RNA for FOXO3 (siFOXO3) to study the effects of Forkhead Box O3 (FOXO3) on the autophagy of BM-MSCs[4]to pre-incubate villi to inhibit the mammalian target of rapamycin complex 1 (mTORC1) signaling[5]
- Biochem/physiol Actions: A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.
- Features and Benefits: This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
- Other Notes: Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Carc. 2 - Repr. 2
WGK
WGK 2
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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product name: Rapamycin from Streptomyces hygroscopicus, ≥95% (HPLC), powder
Quality Level: 300
Assay: ≥95% (HPLC)
form: powder
color: off-white
solubility: ethanol: 2 mMDMSO: soluble
antibiotic activity spectrum: fungiyeast
Mode of action: enzyme | inhibitsprotein synthesis | interferes
storage temp.: −20°C
SMILES string: CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
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