D9891
Doxycycline hyclate
Manufacturer: Sigma Aldrich
CAS Number: 24390-14-5
Synonym(S): 6-Desoxy-5-hydroxytetracycline hydrochloride hemihydrate hemiethanolate, Doxycycline hydrochloride hemiethanolate hemihydrate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 G | D9891-1-G | In Stock | ₹ 6,094.48 |
| 5 G | D9891-5-G | In Stock | ₹ 18,056.10 |
| 10 G | D9891-10-G | In Stock | ₹ 23,501.08 |
| 25 G | D9891-25-G | In Stock | ₹ 30,959.50 |
| 100 G | D9891-100-G | In Stock | ₹ 1,20,157.50 |
D9891 - 1 G
In Stock
Quantity
1
Base Price: ₹ 6,094.48
GST (18%): ₹ 1,097.006
Total Price: ₹ 7,191.486
biological source
synthetic
Quality Level
200
Assay
≥93.5% (HPLC)95.0-102.0% anhydrous basis (ethanol free based)
form
powder
storage condition
(Tightly closed. Dry. )
color
yellow to yellow-green
antibiotic activity spectrum
Gram-negative bacteriaGram-positive bacteriamycoplasmaparasites
Mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58
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Description
- General description: Doxycycline Hyclate, a synthetic tetracycline antibiotic, demonstrates broad-spectrum antimicrobial activity against various bacteria by binding to the 30S and potentially the 50S ribosomal subunits. This binding disrupts the aminoacyl-tRNA binding to the mRNA-ribosome complex, effectively inhibiting bacterial protein synthesis, thereby halting growth and replication. Beyond its antimicrobial effects, Doxycycline Hyclate serves as an inhibitor of matrix metalloproteinases (MMPs), enzymes crucial for collagen breakdown in connective tissues. Studies on corneal erosion and rheumatoid arthritis showcase its significant reduction in MMP-9 and MMP-8 levels, respectively. This MMP-inhibiting property helps preserve collagen integrity, preventing excessive tissue degradation and supporting tissue repair.In cell biology, Doxycycline Hyclate impacts smooth muscle cells, enhancing adhesion and influencing the reorganization of fibrillar collagen matrices. Its influence on apicoplast gene expression in Plasmodium falciparum, the malaria-causing parasite, adds a dimension of significance in infectious disease research. Additionally, the inhibition of tissue formation in rat studies contributes to its relevance in understanding tissue development. Moreover, Doxycycline Hyclate holds potential in metabolomics research, considering its multi-faceted effects on various cellular processes. In the broader context of biochemical research, its versatile actions make it a valuable tool for investigating molecular mechanisms and signaling pathways.
- Application: Doxycycline hyclate has been used for the induction of glioma cells[1] and human embryonic kidney 293T cells (HEK293T).[2]
- Biochem/physiol Actions: Mode of Action: Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi.Activity Spectrum: Effective against a broad spectrum inhibitor of matrix metalloproteinases in vivo.
- Features and Benefits: High-quality antibiotic suitable for multiple research applicationsIdeal for Cell Biology, Metabolomics, and Biochemical research.
- Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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biological source: synthetic
Quality Level: 200
Assay: ≥93.5% (HPLC)95.0-102.0% anhydrous basis (ethanol free based)
form: powder
storage condition: (Tightly closed. Dry. )
color: yellow to yellow-green
antibiotic activity spectrum: Gram-negative bacteriaGram-positive bacteriamycoplasmaparasites
Mode of action: protein synthesis | interferes
storage temp.: 2-8°C
SMILES string: Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58
biological source:
synthetic
Quality Level:
200
Assay:
≥93.5% (HPLC)95.0-102.0% anhydrous basis (ethanol free based)
form:
powder
storage condition:
(Tightly closed. Dry. )
color:
yellow to yellow-green
antibiotic activity spectrum:
Gram-negative bacteriaGram-positive bacteriamycoplasmaparasites
Mode of action:
protein synthesis | interferes
storage temp.:
2-8°C
SMILES string:
Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58
biological source: __
Quality Level: 100
Assay: __
form: lyophilized powder
storage condition: __
color: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: 2-8°C
SMILES string: __
biological source:
__
Quality Level:
100
Assay:
__
form:
lyophilized powder
storage condition:
__
color:
__
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
2-8°C
SMILES string:
__
biological source: __
Quality Level: 200
Assay: 98%
form: liquid
storage condition: __
color: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: __
SMILES string: [H]P(=O)(OCC)OCC
biological source:
__
Quality Level:
200
Assay:
98%
form:
liquid
storage condition:
__
color:
__
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
__
SMILES string:
[H]P(=O)(OCC)OCC
biological source: __
Quality Level: 200
Assay: 95%
form: liquid
storage condition: __
color: __
antibiotic activity spectrum: __
Mode of action: __
storage temp.: 2-8°C
SMILES string: CCOC(CP(=O)(OCC)OCC)OCC
biological source:
__
Quality Level:
200
Assay:
95%
form:
liquid
storage condition:
__
color:
__
antibiotic activity spectrum:
__
Mode of action:
__
storage temp.:
2-8°C
SMILES string:
CCOC(CP(=O)(OCC)OCC)OCC