M4135
α-Melanocyte stimulating hormone
≥97% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 581-05-5
Synonym(S): α-MSH, α-Melanotropin
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | M4135-1-MG | In Stock | ₹ 14,494.68 |
| 5 MG | M4135-5-MG | In Stock | ₹ 45,627.38 |
M4135 - 1 MG
In Stock
Quantity
1
Base Price: ₹ 14,494.68
GST (18%): ₹ 2,609.042
Total Price: ₹ 17,103.722
biological source
synthetic (organic)
Quality Level
200
sterility
non-sterile
Assay
≥97% (HPLC)
form
powder
solubility
water: 1.00-1.04 mg/mL, clear, colorless
UniProt accession no.
P01189
shipped in
ambient
storage temp.
−20°C
SMILES string
CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N6CCC[C@H]6C(=O)N[C@@H](C(C)C)C(N)=O
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-P0252 5mg , α-MSH CAS:581-05-5 Purity:>98% | Medchemexpress LLC | ₹ 17,787.92 | |
 | Sigma Aldrich Fine Chemicals Biosciences alpha-Melanocyte stimulating hormone | 581-05-5 | MFCD00133062 | 1 mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 14,149.91 | |
 | 581-05-5 | N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide | A2B Chem | ₹ 10,096.08 - ₹ 18,994.32 |
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Description
- Amino Acid Sequence: Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
- General description: α-Melanocyte-stimulating hormone (α-MSH) is a tridecapeptide, mostly produced by the cells in the brain, pituitary and circulation.[1] Pro-inflammatory cytokines or UV light induced epidermal cells such as keratinocytes and melanocytes synthesize and discharge α–MSH. Poopiomelanocortin (POMC) acts as a precursor for α-Melanocyte-stimulating hormone (α-MSH) production.[2]
- Application: α-Melanocyte stimulating hormone (α–MSH) has been used for following studies: it has been Intracerebroventricularly (icv) injected to mice for behavioral studies.[3] to determine the effect of α−MSH on growth of stationary Nb 2 node lymphoma cell cultures.[4] to determine the effect of α−MSH on leptin secretion in the primary cultures of differentiated adipocytes.[5] α−MSH promoted melanin production in the B16-F1 cells from murine melanoma cell line.[6]
- Biochem/physiol Actions: α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α−MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α–MSH functions as a potent therapeutics for various conditions resulted through NF-κB activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock.[1] α-MSH has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.[2]
- Antibody Adsorbant: Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
- Linkage: Derived from ACTH 1-13
- Other Notes: Lyophilized from 0.1% TFA in H2O
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Compare Similar Items
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biological source: synthetic (organic)
Quality Level: 200
sterility: non-sterile
Assay: ≥97% (HPLC)
form: powder
solubility: water: 1.00-1.04 mg/mL, clear, colorless
UniProt accession no.: P01189
shipped in: ambient
storage temp.: −20°C
SMILES string: CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N6CCC[C@H]6C(=O)N[C@@H](C(C)C)C(N)=O
biological source:
synthetic (organic)
Quality Level:
200
sterility:
non-sterile
Assay:
≥97% (HPLC)
form:
powder
solubility:
water: 1.00-1.04 mg/mL, clear, colorless
UniProt accession no.:
P01189
shipped in:
ambient
storage temp.:
−20°C
SMILES string:
CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N6CCC[C@H]6C(=O)N[C@@H](C(C)C)C(N)=O
biological source: __
Quality Level: 200
sterility: __
Assay: >98% (TLC)
form: powder
solubility: __
UniProt accession no.: __
shipped in: __
storage temp.: 2-8°C
SMILES string: CSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O
biological source:
__
Quality Level:
200
sterility:
__
Assay:
>98% (TLC)
form:
powder
solubility:
__
UniProt accession no.:
__
shipped in:
__
storage temp.:
2-8°C
SMILES string:
CSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O
biological source: __
Quality Level: 200
sterility: __
Assay: >98% (TLC)
form: powder
solubility: __
UniProt accession no.: __
shipped in: __
storage temp.: 2-8°C
SMILES string: CSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O
biological source:
__
Quality Level:
200
sterility:
__
Assay:
>98% (TLC)
form:
powder
solubility:
__
UniProt accession no.:
__
shipped in:
__
storage temp.:
2-8°C
SMILES string:
CSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O
biological source: goat
Quality Level: 200
sterility: __
Assay: __
form: __
solubility: __
UniProt accession no.: __
shipped in: dry ice
storage temp.: −20°C
SMILES string: __
biological source:
goat
Quality Level:
200
sterility:
__
Assay:
__
form:
__
solubility:
__
UniProt accession no.:
__
shipped in:
dry ice
storage temp.:
−20°C
SMILES string:
__