Amoxicillin trihydrate: potassium clavulanate (4:1)

Description

• General description: Amoxicillin trihydrate is a semisynthetic antibiotic, that is used as a medicine.[1]
• Application: Amoxicillin trihydrate: potassium clavulanate (4:1) has been used to study its effect on the viral déjà vu disease (neonatal intracerebral (i.c.) infection) in mice model.[2]
• Biochem/physiol Actions: Amoxicillin trihydrate is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria.[3][4] Since amoxicillin is degraded by β-lactamases, it does not show activity against bacteria which produce these enzymes.Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases[5] found in bacteria that are resistant to penicillins and cephalosporins.[6]Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.[7]
• Packaging: 1G
• Components: Material is a powdered mixture of 4 parts amoxicillin trihydrate to 1 part potassium clavulanate.
• Storage and Stability: Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.
• Other Notes: Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.